Анастасія Цвітун

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Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease.

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Demographische Alterung und technischer Fortschritt sind maßgebliche Ursachen für steigende Ausgaben im Gesundheitswesen. Reaktionen hierauf sind zusehends Beitragssatzsteigerungen und Kostendämpfungsmaßnahmen, weshalb der Markt für Gesundheitsgüter seine Wachstumspotenziale nicht voll auszuschöpfen vermag. In dieser Arbeit werden die positiven Aspekte der Gesundheit für die wirtschaftliche Entwicklung herausgearbeitet. Darüber hinaus wird das Zusammenspiel von Gesundheit und Bildung analysiert, da Bildung die Rolle eines zentralen Wachstumsmotors zukommt. Eine empirische Untersuchung gibt zudem Aufschluss über die wesentlichen Determinanten eines guten Gesundheitsverhaltens sowie einer guten Gesundheit als Voraussetzung für stetiges Wirtschaftswachstum.

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The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.

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Can early criminal defense helping to avoid or shorten detention? When early criminal defense means to avoid unnecessary detention which burdens both the involved parties, the enforcement and detention and in terms of costs, the state in unnecessary ways? These questions are discussed in the present investigation. It represents the concept and the results of the accompanying scientific research from a 1998 pilot project carried out in the JVA Hannover. It relies on the analysis of over 1,300 criminal acts and the Federal Central Register’s (Bundeszentralregister) statements, the evaluation of the detention list of the local court of Hanover and on extensive interviews with people involved in the project (defence lawyers, prosecutors, judges, court clerks and remand prisoners). The empirical findings of the accompanying be embedded in a legal framework and criminological conclusions are presented.Kann frühe Strafverteidigung dazu beitragen, Untersuchungshaft zu vermeiden oder zu verkürzen? Ist frühe Strafverteidigung damit ein Mittel, um unnötige Haftzeiten zu vermeiden, die sowohl die Betroffenen als auch den Untersuchungshaftvollzug und über die Haftkosten den Staat in überflüssiger Weise belasten? Diesen Fragen geht die vorliegende Untersuchung nach. Sie stellt die Konzeption und die Ergebnisse der wissenschaftlichen Begleitforschung zu einem ab 1998 in der JVA Hannover durchgeführten Modellprojekt vor. Dabei stützt sie sich auf die Auswertung von über 1.300 Strafverfahrensakten und Bundeszentralregisterauszüge, auf die Auswertung der Haftliste des Amtsgerichts Hannover und auf umfangreiche Befragungen der am Projekt beteiligten Personen (Verteidiger, Staatsanwälte, Richter, Justizangestellte und Untersuchungsgefangene). Die empirischen Erkenntnisse der Begleitforschung werden in einen rechtlichen Rahmen eingebettet und kriminologische Schlussfolgerungen werden vorgestellt.

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