The Commercial Review

Articles. Tuesday, August 12, 2014; Monday, March 23, 2009.

Richard A. Shiflett

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The Internet of Things offers massive societal and economic opportunities while at the same time significant challenges, not least the delivery and management of the technical infrastructure underpinning it, the deluge of data generated from it, ensuring privacy and security, and capturing value from it. This Open Access Pivot explores these challenges, presenting the state of the art and future directions for research but also frameworks for making sense of this complex area. This book provides a variety of perspectives on how technology innovations such as fog, edge and dew computing, 5G networks, and distributed intelligence are making us rethink conventional cloud computing to support the Internet of Things. Much of this book focuses on technical aspects of the Internet of Things, however, clear methodologies for mapping the business value of the Internet of Things are still missing. We provide a value mapping framework for the Internet of Things to address this gap. While there is much hype about the Internet of Things, we have yet to reach the tipping point. As such, this book provides a timely entrée for higher education educators, researchers and students, industry and policy makers on the technologies that promise to reshape how society interacts and operates.

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Ferdinand Ebner is next to Ludwig Wittgenstein the most important Austrian philosopher of language in the 20th century. In his main work Das Wort und die geistigen Realitäten. Pneumatologische Fragmente Ebner produces a new form of anthropology, which is based on a dialogic orientated understanding of human beings. Beside his philosophical works Ebner wrote many letters and diaries. One of the 14 existing diaries is the so-called "Mohlauer Tagebuch" from the 23rd of July to the 28 th of August 1920, which is kept on the "Brenner Archiv" in Innsbruck together with the philosophical texts and the letters. In this diary Ebner writes about his stay in Mühlau, a village near Innsbruck, where he was a guest of Ludwig von Ficker for one month and which was the beginning of a long friendship with the publisher of the Brenner. Ficker, who had already published some articles of Ebner in the Brenner, printed the Fragmente 1921, two years after Ebner wrote them. In this way Ficker became the publisher, promoter and friend of Ebner. According to some passages of the diary, Ebner experienced in Ficker a kind of acceptance and security, which he did not know before. This feeling of well-being is also a part of the deep impressions of nature, which Ebner got on many walks through the surrounding of Innsbruck. Although he was a thinker, who always emphasized the meaning of the word, these impressions showed him the limits of language. Ebner's basic opinions are presentated very clearly in his meetings with different members of the Brenner-circle and in the confrontation with the intellectual movements of the time. An example are his talks with Paul Bargehr about Buddhism, who was newly rediscovered in Europe in those days. Ebner understood the good will of Bargehr, but he cannot accept Buddhism as a solution for the big problems of the Europeans. In spite of Ebners turn to Christianity some years before the diary also shows the difficulties in the relation between Ebner and the Catholic church. Of special interest is Ebner's meeting with the painter Erich Lechleitner. In front of Lechleitner's pictures he has doubts about his radical pessimism concerning art and culture.The text of the diary is followed by a commentary, which explains the biographical, literary, philosophical, historical, etc. connections of passages in the diary. The three essays following the commentary give an overview of Ebners biographical, philosophical and cultural background. Monika Seekircher's essay includes a short biography of Ebner and describes the most important personal relations in his life as well as his intellectual developement. Richard Hörmann tries to show the connections between the diary and the Fragmente, because many entries of the diary can only be understood on the basis of the main thoughts of the Fragmente. The topic of Walter Methlagl's essay is the local cultural context, in which the diary is embedded. Special attention is given to the intellectual movements within the Brenner-circle. The numerous photos depict persons, who are mentioned in the diary, places as they then looked and the pictures by painters named in the diary.Ferdinand Ebner (1882-1931) ist neben Ludwig Wittgenstein der bedeutendste österreichische Sprachdenker des 20. Jahrhunderts. In seinem Hauptwerk Das Wort und die geistigen Realitäten. Pneumatologische Fragmente entwickelt Ebner eine neue Form von Anthropologie, die auf einem dialogisch geprägten Verständnis des Menschen basiert. Neben seinen philosophischen Schriften verfaßte Ebner aber auch unzählige Briefe und war zudem ein intensiver Tagebuchschreiber. Das sogenannte "Mühlauer Tagebuch" vom 23.7. bis 28.8.1920 ist eines von insgesamt 14 erhaltenen Tagebüchern Ebners, welche neben dem philosophischem Nachlaß und den Briefen am Brenner-Archiv aufbewahrt werden. In diesem Tagebuch schildert Ebner seinen einmonatigen Aufenthalt bei Ludwig von Ficker in Mühlau bei Innsbruck, der der Beginn einer jahrelangen Freundschaft ist. Ficker, der bereits einige Aufsätze Ebners in seiner Zeitschrift Der Brenner publiziert hat, läßt 1921 auch Ebners bereits 1919 fertiggestellte Fragmente im Brenner-Verlag erscheinen. So wird Ficker Ebners Verleger, Förderer und Freund. Aus mehreren Tagebucheintragungen geht hervor, daß Ebner bei Ficker eine Akzeptanz und Freundlichkeit erfährt, die ihm bisher fremd waren. Dieses für Ebner so seltene Gefühl des Wohlbefindens erfährt er auch bei seinen zahlreichen Spaziergängen mit Ficker, die zu intensiven Naturerlebnissen führen, sodaß Ebner, der die Bedeutung des Wortes immer wieder betont, auch Grenzen der sprachlichen Möglichkeiten wahrnimmt. Ebners geistige Einstellung tritt ganz klar und markant in der Begegnung mit verschiedenen Persönlichkeiten aus dem Brenner-Kreis und in der Auseinandersetzung mit den verschiedenen geistigen Strömungen zu dieser Zeit hervor. So wird er z.B. in der Person von Paul Bargehr mit dem Buddhismus konfrontiert, dem gegenüber er sich wenn auch nicht verständnislos so doch skeptisch äußert. Immer wieder zeigt sich auch seine Ablehnung der katholischen Amtskirche trotz seiner erst einige Jahre zuvor erfolgten Hinwendung zum Christenturn. Besonders interessant ist Ebners Begegnung mit dem Maler Erich Lechleitner. Angesichts seiner Bilder gerät er in einen Zwiespalt mit seinem eigenen rigorosen Kulturpessimismus.Dem Tagebuchtext folgt ein Einzelstellenkommentar, in dem biographische, literarische, philosophische, historische u.a. Anspielungen geklärt werden. Die drei Aufsätze, die an den Einzelstellenkommentar anschließen, sind als Flächenkommentar zu verstehen, d.h. sie stellen eine breitere Form der Kommentierung dar, wobei der biographische, der philosophische und der kulturelle Hintergrund Ebners aufgezeigt wird. Monika Seekircher liefert eine etwas umfassendere Kurzbiographie Ebners, wobei neben Ebners Lebensdaten auch seine wichtigsten persönlichen Beziehungen und seine geistige Entwicklung kurz dargestellt werden. Richard Hörmann versucht in seinem Aufsatz, den Zusammenhang des Tagebuchs mit Ebners Fragmenten aufzuzeigen, da sehr viele Stellen des Tagebuchs nur vor dem Hintergrund der Fragmente richtig zu verstehen sind. Walter Methlagl bettet das Tagebuch in den lokalen kulturellen Kontext ein, wobei er insbesondere auf die geistigen Strömungen im Brenner-Kreis eingeht. Das umfangreiche Bildmaterial dient der Veranschaulichung und ermöglicht somit eine konkrete Vorstellung von den im Tagebuch erwähnten Personen, den Örtlichkeiten zu dieser Zeit und von den Bildern der im Tagebuch genannten Maler.

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Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies.

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