Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging.This book is made open access as part of the Knowledge Unlatched KU Select 2018: STEM Backlist Books
Assessing the transformation of Russian nationalist discourse in the 21st century Russian nationalism, previously dominated by imperial tendencies pride in a large, strong and multi-ethnic state able to project its influence abroad is increasingly focused on ethnic issues. This new ethno-nationalism has come in various guises, like racism and xenophobia, but also in a new intellectual movement of national democracy deliberately seeking to emulate conservative West European nationalism. Russias annexation of Crimea in 2014 and the subsequent violent conflict in Eastern Ukraine utterly transformed the nationalist discourse in Russia. This book provides an up-to-date survey of Russian nationalism as a political, social and intellectual phenomenon by leading Western and Russian experts in the field of nationalism studies. It includes case studies on migrantophobia; the relationship between nationalism and religion; nationalism in the media; nationalism and national identity in economic policy; nationalism in the strategy of the Putin regime as well as a survey-based study of nationalism in public opinion. Hardcover available from Edinburgh University Press. This title was made Open Access by libraries from around the world through Knowledge Unlatched.
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Neuroendocrinology is the discipline that investigates the interplay between the nervous and endocrine systems i.e. the control of endocrine glands by the central and peripheral nervous systems, the action of hormones on nerve cells and the production of hormones by the nervous system. The present Research Topic is a compilation of contributions stemming from the 8th International Congress of Neuroendocrinology (ICN2014) held in Sydney, Australia, that illustrates various facets of current neuroendocrine research.
On the night of August 22, 2025, a 23-year-old Ukrainian refugee, Iryna Zarutska, boarded Charlotte’s LYNX Blue Line train after a shift at a local pizzeria. https://townhall.com/columnists/yurivanetik/2025/10/02/senseless-murder-of-iryna-zarutska-is-political-rorschach-n2664307
Wie schreibt man Geschichte? Welche Möglichkeiten gibt es, sich mit Geschichte zu beschäftigen, sie darzustellen und an andere zu vermitteln? Die spätmittelalterliche und frühneuzeitliche Geschichtsschreibung ist ein zentrales Experimentierfeld der Historiografie, in das die hier ausgewählten und präsentierten Beispiele Einblicke vermitteln. Die damit angebotene Neustrukturierung des historiografischen Feldes geht weit über das hinaus, was die Historiografiegeschichtsschreibung des 19. und 20. Jahrhunderts herausgestellt hat, und erweitert den Horizont über die Konstrukte moderner Geschichtswissenschaft hinaus erheblich.Dieses Quellenhandbuch richtet sich an ein interdisziplinäres, universitäres Publikum: an fortgeschrittene Studierende und Promovierende und an Lehrende für die Verwendung im Unterricht oder an Forscher/innen, die sich über die neueren Tendenzen auf dem Gebiet der Historiografiegeschichte informieren wollen. Der Einsatz des Handbuchs bietet sich vor allem für neue Masterstudiengänge mit historischem oder kulturwissenschaftlichem Schwerpunkt an (Geschichte des Spätmittelalters, der Renaissance, der Frühen Neuzeit, Kultur-, Literatur-, Kirchen-, Wissensgeschichte etc.), weil damit Grundlagenwissen der Historiografiegeschichte quellennah und auf dem neuesten Stand der Forschung vermittelt werden kann.
Catechols are widely found in nature taking part in a variety of biological functions, ranging from the aqueous adhesion of marine organisms to the storage of transition metal ions. Catechol-based natural and biomimetic molecules have thus been the focus of intense research aimed at mimicking and translating this nature-inspired chemistry into new functional materials and systems with tailored properties. The aim of this book is to present a concise survey of the state-of-the-art of basic and applied research on bioinspired catechol systems. It collects several cutting-edge contributions from leading laboratories with a unifying theme of biomimetic principles and approaches. It is hoped that both practitioners and newcomers to the field will by fascinated by the unique potential of biomimetics to pursue new research and innovative solutions in biomedicine and technology.
Ladislav Mňačko's Werke wurden in 30 Sprachen übersetzt und erlebten weltweit eine Gesamtauflage von mehreren Millionen. Das Interesse an diesem Autor und seinem Werk schlug sich nicht zuletzt dank Mňačko's Engagement in der tschechoslowakischen Reformbewegung, die im "Prager Frühling" gipfelte in Dutzenden von Artikeln und Rezensionen nieder. Ladislav Mňačko kann als der international bekannteste slowakisch schreibende Schriftsteller bezeichnet werden.
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