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An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in pathology in focal cortical regions, but abnormalities in subcortical structures, such as thalamus and basal ganglia, and in intercortical and intracortical connecting white matter pathways. Novel methods of treating refractory epilepsy are urgently needed. The goal of identifying for each affected individual the specific brain regions that are involved offers the promise that novel methods of treatment will one day be developed that specifically target those abnormal regions. Researchers from disparate fields are required to develop and advance this area of research, and this current topic proposes to place a spotlight on the “state of the art” of methods to identify the abnormal networks. Recent work covering a wide variety of disciplines and technologies, including dense array electroencephalography (dEEG), novel methods of analyses of both the interictal dEEG and intracranial EEG (icEEG), magnetoencephalography (MEG), high-resolution magnetic resonance imaging (MRI), functional MRI (fMRI), simultaneous fMRI-EEG, fMRI connectivity measures, simultaneous dEEG-icEEG, and techniques to coregister patient-specific MRI (including white matter pathways) and dEEG, are all examples of areas of research that have contributed to a greater understanding of potential epileptogenic regions. We asked for individuals with expertise in an area of research that expands an understanding of identifying epileptic networks to contribute to this research topic.
Nos dias de hoje a economia dos serviços, sem a presença da industrialização, tem reproduzido o subdesenvolvimento, como nos países cujas ocupações em expansão não oferecem um horizonte decente e sustentável de futuro justo e democrático a todos. Mesmo nas indústrias de tecnologia das informações e comunicações, os empregos disponíveis são de pequena monta e parcela ainda precários, o que indica o quanto o tema da industrialização segue sendo central para qualquer país que almeja o desenvolvimento.
Der Band untersucht anthropologische, psychologische, rechtliche und ethische Probleme des Willenskonzepts. Die Medizin führt Menschen in Grenzsituationen, in denen «ihr Wille» in vielerlei Hinsichten problematisch wird: Kinder sollen in die Durchführung medizinischer Maßnahmen einwilligen; Menschen mit Demenz können sich zu Therapien manchmal nicht mehr klar äußern; potentielle Teilnehmende einer klinischen Studie sind durch deren Komplexität überfordert, sollen aber zustimmen. Der Band fokussiert bewusst Randzonen, in denen nicht klar ist, was ein Wille ist und ob eine Willensäußerung vorliegt. An diesen Randbereichen wird besser als in thematischen Kernzonen sichtbar, was Idee und Praxis des Willens leisten und was sie verdecken. Daraus ergeben sich neue Fragen zur Problematik des Entscheidens und der Einwilligung in Grenzsituationen.
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At the beginning of the 1960s, Swedish researchers started a sociological study of all children born in Stockholm in 1953, Project Metropolitan. This book describes the project’s at times dramatic history, where issues of personal integrity and the role of social sciences were heavily debated. These discussions were fueled by the rapid and far-reaching digitalization in society at large and also within social sciences. As such, Project Metropolitan came to symbolize the benefits and potential risks related to an expanding body of research based on large groups of individuals and multiple register data sources. At the outset, the project’s founders sought to answer the following question: “Why do some get on better in life than others?” One of the main aims of the project was to study the long-term impact of conditions in childhood. The book therefore also includes an updated presentation of the main findings, as they have been conveyed in over 160 publications to date. These publications cover a wide array of topics and phenomena such as social mobility and education, substance abuse and crime, health and ill-health, peer influences and family relations, and adult lives of adopted children. Today Project Metropolitan is known as the “Stockholm Birth Cohort Multigenerational Study (SBC Multigen)” and is still in full vigor. From its original group of 15,000 children, the study has become multi-generational by adding data about their parents, siblings, children, nieces and nephews. As they approach their late 60s, it will also be possible to follow these “children” into retirement and old-age. In the concluding chapter the author discusses some of the challenges contemporary social research is facing. What are the current threats to academic freedom and what opportunities do the unique data registers in countries like Sweden provide?
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Una guida semplice e completa per imparare a usare correttamente il passivo in italiano con 'essere', 'venire' e 'andare'. Regole chiare, esempi pratici ed esercizi utili per studenti di italiano L2/LS.
Academic institutions are starting to recognize the growing public interest in digital humanities research, and there is an increasing demand from students for formal training in its methods. Despite the pressure on practitioners to develop innovative courses, scholarship in this area has tended to focus on research methods, theories and results rather than critical pedagogy and the actual practice of teaching. The essays in this collection offer a timely intervention in digital humanities scholarship, bringing together established and emerging scholars from a variety of humanities disciplines across the world. The first section offers views on the practical realities of teaching digital humanities at undergraduate and graduate levels, presenting case studies and snapshots of the authors’ experiences alongside models for future courses and reflections on pedagogical successes and failures. The next section proposes strategies for teaching foundational digital humanities methods across a variety of scholarly disciplines, and the book concludes with wider debates about the place of digital humanities in the academy, from the field’s cultural assumptions and social obligations to its political visions. Digital Humanities Pedagogy broadens the ways in which both scholars and practitioners can think about this emerging discipline, ensuring its ongoing development, vitality and long-term sustainability.