Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.
Computers and other equipment in an organization can attach thanks to cabling services from the network cabling services business.
A lady of the weeping willow tree -- The very naked boy -- Jonathan makes a wish.
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The National Board for Certification in Occupational Therapy (NBCOT) administers the Occupational Therapist Registered (OTR) certification exam to ensure that individuals who wish to practice as licensed occupational therapists meet certain competency standards. The OTR exam assesses the test-taker's knowledge and skills in various areas of occupational therapy. The OTR exam is a computer-based exam that consists of 170 multiple-choice questions, of which 20 questions are unscored pilot questions. The exam is administered at Prometric testing centers across the United States and is typically completed within four hours. To be eligible to take the OTR exam, candidates must have earned a degree from an accredited occupational therapy program, completed all fieldwork requirements, and applied for certification through the NBCOT.
This book presents, above all, a study of the establishment and development of the Soviet organization and system of fashion industry and design as it gradually evolved in the years after the Second World War in the Soviet Union, which was, in the understanding of its leaders, reaching the mature or last stage of socialism when the country was firmly set on the straight trajectory to its final goal, Communism. What was typical of this complex and extensive system of fashion was that it was always loyally subservient to the principles of the planned socialist economy. This did not by any means indicate that everything the designers and other fashion professionals did was dictated entirely from above by the central planning agencies. Neither did it mean that their professional judgment would have been only secondary to ideological and political standards set by the Communist Party and the government of the Soviet Union. On the contrary, as our study shows, the Soviet fashion professionals had a lot of autonomy. They were eager and willing to exercise their own judgment in matters of taste and to set the agenda of beauty and style for Soviet citizens. The present book is the first comprehensive and systematic history of the development of fashion and fashion institutions in the Soviet Union after the Second World War. Our study makes use of rich empirical and historical material that has been made available for the first time for scientific analysis and discussion. The main sources for our study came from the state, party and departmental archives of the former Soviet Union. We also make extensive use of oral history and the writings published in Soviet popular and professional press. This book is part of the Studia Fennica Historica series.
Börsengänge (IPOs) gewinnen trotz ihrer ausgeprägten Zyklik sowohl für Unternehmen als auch für Investoren immer mehr an Bedeutung. Spätestens seit dem Börsengang der Deutschen Telekom im Jahr 1996 und dem Aufstieg und Fall des Neuen Marktes sind sie auch in Deutschland einem breiten Publikum bekannt. Von dieser öffentlichen Aufmerksamkeit können Unternehmen profitieren. Der in dieser Arbeit entwickelte konzeptionelle Analyserahmen ermöglicht erstmals eine grundlegende und umfassende Auseinandersetzung mit der praxisrelevanten Frage, unter welchen Bedingungen und mit welchen Maßnahmen Unternehmen durch einen Börsengang ihren Bekanntheitsgrad und ihr Image signifikant verbessern können. Eine besondere Rolle spielen dabei weit über dem historischen Mittel von 15% liegende Zeichnungsrenditen.
Dredging is an excavation activity usually carried out underwater, in harbors, shallow seas, and freshwater areas with the purpose of gathering up bottom sediments to deepen or widen the sea bottom or sea channel.
The interaction between cells, tissues and biomaterial surfaces are the highlights of the book "Biomimetic Based Applications". In this regard the effect of nanostructures and nanotopographies and their effect on the development of a new generation of biomaterials including advanced multifunctional scaffolds for tissue engineering are discussed. The 2 volumes contain articles that cover a wide spectrum of subject matter such as different aspects of the development of scaffolds and coatings with enhanced performance and bioactivity, including investigations of material surface-cell interactions.
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