Defeat Pain, Don’t Mask it! Webinar for Health Professionals by Dr. Kim Vanderlinden Advances in Absorption of Topical Analgesics Topicals that are not absorbed can only mask pain 3 Rs REACH U. of Minnesota- Radio-labeled RELIEVE J. of Rheumatology- Twice J. of Strength & Conditioning Research- Twice RESTORE J. of Periodontology- Twice August 17, 2010 Abstract “The invention ...... for use in the treatment and prevention of various types of arthritis and other inflammatory joint conditions, periodontal diseases and psoriasis, which avoid many of the side effects associated with known treatments. The composition of the present invention have the advantage of increased stability, a reduction of arachidonic acid in cells, a reduction in eicosanoid production and enhanced cell regulation and US Patent communication. #7,776,914 Discovered in: Researched in: Patented in: Made In: Active Again vs Fish Oil In my experience, omega3s and fish oil do not compare clinically A marine rescue called to say that an older arthritic sea lion was doing much better on Active Again Keep in mind: Sea lions live on fish! Active Again vs Fish Oil I recommend Omega3s for health I recommend Active Again for clinical results World Class Peer-Reviewed Research William J. Kraemer Ph.D. U. of Connecticut, Professor of Medicine The “William Kraemer Award” is given annually to the Top Sports Scientist Professor Kraemer conducted: 3 trials using these oils topically Professor Kraemer was the Editor-In-Chief There are almost 100 Ph.D. associate editors Safety Research Cetylated oils are derived from our food supply. U. of Minnesota researchers fed animals at 1300 times the regular dose and still no pathology was found. This is equivalent to a human dose of 3900 caps/day (3 caps x 1300) Over a billion doses in people have been taken without incident. Do More & Do it Faster For the BEST Results use both cream & caps Remarkable osteoarthritis trial results published twice in the: J. of Rheumatology once using oral caps once using topical cream In studies patients get FAST relief Q: Why is absorption of a topical so important to us? A: Because our patients usually have sore muscles and joints and not sore skin. Some patients think they are feeling “true” muscle and joint pain relief with menthol. However as physicians we know menthol “confuses” nerve endings in the skin in order to act as a counter-irritant. Patients deserve to know the how they work and the limitations of counter-irritants . If a pain cream does not even reach sore muscles and joints, how then is long-term benefit possible? Counterirritant - Wikipedia https://en.wikipedia.org/wiki/Counterirritant A counterirritant is a substance which creates irritation or mild inflammation in one location with the goal of lessening discomfort and/or inflammation in another location. ... Capsaicin, menthol (mint oil), methyl salicylate, and camphor are examples of counterirritants. How It All Started CMO or Cetyl myristoleate is a cetylated oil. CMO was selling for approx $2000 a month in the mid 1990s after receiving a US patent for OA. An earlier CMO patent was issued for RA. The inventor, who was the president of one of the largest contract supplement packaging companies in the US, tried CMO for his own stiffness and pain, and it helped a little. He thought if one cetylated oil helped, then what about all the other cetylated oils? He mixed/researched other cetylated oils until he discovered a far more potent combination of oils that helped him Turning Back the Clock! It also helped his 15 yr old dog that had joint issues for 3 yrs. She often had to be carried, in her 15th year due to the severity A week after she started taking Active Again, “Meggie” was running around like a puppy again and lived to be almost 22 ….all the while moving like a young dog. It is highly unusual clinically to have reduced mobility and function for 3 years and then be OK for 6 years, especially at this very advanced age. Oral Supplement leads to Topical Cream & caps are used by Olympic athletes…..These are not steroids or they would lose their metals The 1st female gold medalist from China in track and field opened the joint capsules and placed the oil on some painful areas. She felt pain relief in minutes! Remember there was no menthol, only the oil Oral Supplement to Topical The inventor investigated by returning to the U. of Minnesota. The researchers who initially established safety of these oils suggested radio-labeling them to see if any were even being absorbed topically. Getting substances past the epidermis to the dermis and beyond is extremely rare Additionally they also radio-labeled the oral joint health supplement for comparison purposes. Active Again as a Topical The oils were found in all the same tissues whether applied topically or when ingested, proving TRUE dermal absorption! 95% of oral cetylated oils were found to be absorbed by the U.of Minnesota researchers Very importantly, the researchers estimated that oral and dermal absorption rates were similar If a pain cream does not reach sore muscles and joints then it is of limited use! NOTE: Needing ultrasound to drive in a topical implies there is limited or no dermal absorption U. of Minnesota researchers found the oils in white blood cell (WBC) membranes WBCs are found in concentration at sites of injury and inflammation. This may explain why these oils are so valuable clinically Active Again as a Topical Date: Thu, Nov 8, 2018 at 10:57 AM Subject: New Message (sent by contact form at HopeScience) To: <[email protected]> Message: I have been in chronic pain since 2012 after having Shingles. Under the care of many doctors (specialists), 22 in only 6 months, I was taking (for 5 and a half years) seizure meds and high dose pain medicine, plus pain clinic care for approximately 2 years. Too many other professionals to mention. Too many other compounded pain creams to even remember, and absolutely useless for me. My husband met someone who offered us another topical cream- it is a FANTASTIC find for me! I am spreading the find! I cannot thank Hope Science enough for this product! Sincerely Grateful Yvonne How Do These Oils Work? Inflammatory Cascade The appearance of labeled oils within cellular membranes, especially those of the white blood cells, coupled with inhibition of thromboxane production or receptor inhibition, suggests that the oils influence the prostaglandin cascade and resulting inflammation. Topical History - Pennsaid Approved In 2009 the 1st topical NSAID was approved as a drug by the FDA after decades of research. It is called Pennsaid and is a non-steroidal containing diclofenac (Voltaren). Why is Pennsaid Special? ABSORPTION- True dermal absorption enables Pennsaid to do more, as it reaches target tissues. A friend, David Garshowitz, invented Pennsaid. I would often test Pennsaid on one knee and Active Again on the other with patients- Patients preferred Active Again Note: This trial was Cream Trial conducted without Journal of Rheumatology menthol PATIENTS WERE TESTED: Before applying the cream 30 minutes after the first application 30 days after applying the cream twice daily OBJECTIVE PARAMETERS: Range of motion Ability to ascend and descend stairs Ease of getting up from a sitting position Balance of patients stepping down SUBJECTIVE PARAMETER: Pain levels World Class Research FAST RESULTS After30 Minutes : pain levels decreased and the ability to perform the various tasks improved after just a single application of the cream. After30 Days : patients improved after applying the cream twice daily, thereby also demonstrating: LONG-TERM benefit My Dad, My First Patient My Dad Broke His Heel in 5 Places 20+ years ago He took glucosamine, MSM etc. and had a ton of fish oils for 10+ years. Wild pacific salmon is a staple in my family. Fishermen would bring us 30 or 40 salmon at a time. Still he often had to almost drag his foot because he could put very little direct pressure on his heel. Due to pain he could only walk 2 to 3 blocks at a time. He started on both Active Again Cream & Caps Pain & Inflammation Conquered! After a month my dad was walking 3 to 4 miles at a time, which he had not done in more than a decade. Plus he had little or no pain and stiffness. As a side benefit of putting the cream on his heel and ankle, the stiffness in his arthritic hands disappeared after only 3 days, never to return! He is now 83 and still walks a couple miles daily without pain or stiffness My dad showed me what was possible with Active Again Peripheral Neuropathy Dear Dr. Kim: I want to express my sincere appreciation for your product…. I developed neuropathy in my feet from a serious back injury back in 1999…... The burning sensation eventually progressed into a severe case of burning and "pins and needles“ that could not be eased without heavy pain medication. …..I was spending 3-5 days a week in the hospital to deal with the pain Unfortunately, the only thing that the hospital could do for me was to give me Dilaudid (morphine derivative) through an IV. ….I experienced a massive reduction in foot pain only 15 minutes after applying the Pain Cream….. The experience of being pain-free for the first time in years was so overwhelming I was brought to tears…. Sincerely, Mark Harris Periodontitis Inflammation Research Thomas Van Dyke Ph.D. This Harvard Professor is best known for his work on the pathways of resolution of inflammation and pathogenesis of periodontal diseases, neutrophil biology, and clinical research. He is considered a World Opinion Leader in Periodontal Research and Inflammation. The Start of the Oils For Periodontal Use The inventor had a friend who had very poor gum health (some pockets were 6 and 7 mm deep) and a number of his teeth were loose. His dentist recommended: Pulling some teeth and replacing with implants. This was to begin in 60 days. The inventor felt the capsules, if opened and the paste applied topically might help and is very safe, so was worth a try. He then gave him a bottle and the rest is history. Remarkable Results! He returned to his dentist after 30 days and the dentist was floored at the improvement. The dentist brought in all his staff to see. Hence the saying “SHOCK the DOC” The gums appeared much healthier, were no longer bleeding and some of the deep pockets were now 3 mm or normal. Plus the teeth were no longer loose! THE DENTAL IMPLANTS WERE CALLED OFF! Journal of Periodontology 2009, 80:1103-1113 Porphyromonas Gingivalis Infection Induced Treated with Active Again Oils Infection Resolved Olive Oil Placebo Infection Advances Bone Loss is Reversed! Active Again Oils Bone loss is the Holy Grail of Dentistry Note: Bone loss occurs when high levels of inflammatory infiltrate damage the adjacent jaw bone/tissue. Journal of Periodontology 2009 There was far less inflammatory infiltrate Active Again Oils 3Rs … RESTORE Why is Dental Research Important for natural healthcare? 1st – The reduction of gum inflammation(redness) is easily visualized- you can see it! 2nd– Absorption is needed for a dental product to work well in this case 3rd – Clinical trials have shown restoration of both bone and soft tissue Tissue restoration is a major scientific advancement! SUPPLEMENT FRAUD? Feb 2015 GNC – Walmart – Walgreen’s - Target 4 of 5 bottles tested contained little or NONE of the listed herbs NY attorney general expands herbal supplements investigation What can we do? Insist on original research (ask your rep for it) and then read it. (patients deserve their doctor be informed) Companies that go to the expense to research and then get a product patented, are far less likely to use cheap and/or generic ingredients. What can we do? Note: If all you are told is “doctor developed” or “contains clinically proven ingredients”…??? it usually means that the actual product was never tested clinically! And what was clinically proven? Many of us assume clinically proven means that a product was shown to be effective. Not so! Glucosamine and/or chondroitin are the classical example of misleading marketing. Glucosamine is proven safe, not effective.
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