Defeat Pain, Don’t Mask it! Webinar for Health Professionals by Dr. Kim Vanderlinden Advances in Absorption of Topical Analgesics Topicals that are not absorbed can only mask pain 3 R s REACH U. of Minnesota- Radio-labeled RELIEVE J. of Rheumatology- Twice J. of Strength & Conditioning Research- Twice RESTORE J. of Periodontology - Twice US Patent # 7,776,914 August 17, 2010 Abstract “The invention ...... for use in the treatment and prevention of various types of arthritis and other inflammatory joint conditions, periodontal diseases and psoriasis , which avoid many of the side effects associated with known treatments. The composition of the present invention have the advantage of increased stability, a reduction of arachidonic acid in cells, a reduction in eicosanoid production and enhanced cell regulation and communication. Discovered in: Researched in: Patented in: Made In: Active Again vs Fish Oil In my experience, omega3s and fish oil do not compare clinically A marine rescue called to say that an older arthritic sea lion was doing much better on Active Again Keep in mind: Sea lions live on fish! I recommend Omega3s for health I recommend Active Again for clinical results Active Again vs Fish Oil William J. Kraemer Ph.D. U. of Connecticut, Professor of Medicine The “William Kraemer Award” is given annually to the Top Sports Scientist Professor Kraemer conducted: 3 trials using these oils topically World Class Peer-Reviewed Research Professor Kraemer was the Editor-In-Chief There are almost 100 Ph.D. associate editors Cetylated oils are derived from our food supply. U. of Minnesota researchers fed animals at 1300 times the regular dose and still no pathology was found. This is equivalent to a human dose of 3900 caps/day (3 caps x 1300) Over a billion doses in people have been taken without incident. Safety Research Remarkable osteoarthritis trial results published twice in the: J. of Rheumatology once using oral caps once using topical cream For the BEST Results use both cream & caps In studies patients get FAST relief Do More & Do it Faster Q: Why is absorption of a topical so important to us? A: Because our patients usually have sore muscles and joints and not sore skin Some patients think they are feeling “true” muscle and joint pain relief with menthol. However as physicians we know menthol “confuses” nerve endings in the skin in order to act as a counter-irritant. Patients deserve to know the how they work and the limitations of counter-irritants If a pain cream does not even reach sore muscles and joints, how then is long-term benefit possible? Counterirritant - Wikipedia https://en.wikipedia.org/wiki/ Counterirritant A counterirritant is a substance which creates irritation or mild inflammation in one location with the goal of lessening discomfort and/or inflammation in another location. ... Capsaicin, menthol (mint oil), methyl salicylate, and camphor are examples of counterirritants. CMO or Cetyl myristoleate is a cetylated oil. CMO was selling for approx $2000 a month in the mid 1990s after receiving a US patent for OA. An earlier CMO patent was issued for RA. The inventor, who was the president of one of the largest contract supplement packaging companies in the US, tried CMO for his own stiffness and pain, and it helped a little. He thought if one cetylated oil helped, then what about all the other cetylated oils? He mixed/researched other cetylated oils until he discovered a far more potent combination of oils that helped him How It All Started Turning Back the Clock! It also helped his 15 yr old dog that had joint issues for 3 yrs. She often had to be carried , in her 15 th year due to the severity A week after she started taking Active Again, “ Meggie ” was running around like a puppy again and lived to be almost 22 ....all the while moving like a young dog. It is highly unusual clinically to have reduced mobility and function for 3 years and then be OK for 6 years, especially at this very advanced age. Oral Supplement leads to Topical C ream & caps are used by Olympic athletes.....These are not steroids or they would lose their metals The 1 st female gold medalist from China in track and field opened the joint capsules and placed the oil on some painful areas. She felt pain relief in minutes! Remember there was no menthol, only the oil Oral Supplement to Topical The inventor investigated by returning to the U. of Minnesota. The researchers who initially established safety of these oils suggested radio-labeling them to see if any were even being absorbed topically. Getting substances past the epidermis to the dermis and beyond is extremely rare Additionally they also radio-labeled the oral joint health supplement for comparison purposes. Active Again as a Topical The oils were found in all the same tissues whether applied topically or when ingested, proving TRUE dermal absorption! Very importantly, the researchers estimated that oral and dermal absorption rates were similar 95 % of oral cetylated oils were found to be absorbed by the U.of Minnesota researchers