Final Report on Policy Research Service Project (The back) (side) (obverse) [2019] soup end Publication registration number feeling 11-1352159-001220-01 salt Policy Research Service Project bottle top Final Result Report group versus Huh sinker true I'm Approximate [2019] National Infectious Disease Crisis Response Promotion Strategy this line For fulfillment of top Pan-Ministry R&D Implementation plan and One tiger New business planning research part wife R [2019] A Study on the Research Plan for the Drive Plan of & D Multi-Agency R&D Program to Implement the National city Responding strategy of line week of system Infectious Diseases stroke ( Caution Contents) And God Gyu ( • Written 14 point Gothic) four work group stroke year phrase 2 0 One 9 Host Research Institution: Co., Ltd. Knowledge Works quality bottle tube Lee example part Center for Disease Control ※ Caution content week of One. This report is the research results of the policy research service project conducted by the Korea Centers for Disease Control and Prevention. This is an inspection report. 2. When publishing the contents of this report, It must be revealed that it is the research result of the policy research service project. 3. Contents necessary for the confidentiality of national science and technology must be publicly announced or disclosed It should not be. -i- -ii- neck car Ⅰ. Summary of Research Results ( Hangul) ... ... ... ·· viii ( English) ... ... ... ····· ix Ⅱ. Policy Research Service Project Research Results My One Chapter final goal ... ... ························· One My One Clause goal ... ... ... One One. Background and necessity of research ... ... One 2. Research goals and content ... ... 5 My 2 Section Goal achievement and contribution to related fields ... ············ 17 My 2 Domestic and foreign technology status ... ... ········ 18 My One Section Status of infectious diseases in Korea ... ... 18 My 2 Section domestic infectious disease R&D Investment status ... ... 27 My 3 Section Current Status of International Cooperation in Infectious Diseases ... ··········· 34 My 4 Section Overseas Infectious Disease International Cooperation Research Status ... ··········· 52 One. International Cooperation in Infectious Diseases in Major Countries ... ························· 52 2. Major programs for international cooperation research on infectious diseases ... · 55 My 5 Infectious Disease International Cooperation Research-related Domestic Researcher Demand ... ···· 61 One. Technology development demand ... ... ······· 61 2. Difficulties in International Cooperation Research ... ... 83 My 6 Section Key Issues and Implications ... ... 84 My 3 Chapter Final Research Contents and Methods ... ... 89 My One Section Existing Infectious Disease R&D Differentiation from business ... ... 89 My 2 Section project promotion plan ... ... ... 91 One. Business direction and outline ... ... 91 2. Business vision and goals ... ... 93 My 4 Chapter Final Research Results ... ... ... 94 -iii- My One Setting up a task to be promoted ... ... ········ 94 My 2 Section Main contents by strategic task ... ... 95 [ Strategic task One] Asian stronghold god · International Cooperation Research Center for Response to Variant Infectious Diseases ... 95 [ Strategic task 2] Africa · Center for International Cooperation in Response to High-Risk Infectious Diseases in South America ·· 97 [ Strategic task 3] Europe · Center for International Cooperation in Overcoming Unresolved Infectious Diseases in North America ... 99 [ Strategic task 4] domestic · Establishment of infrastructure for collecting and sharing other resource information ... 101 My 5 Chapter Research Results Review and Conclusion ... ... 104 My One Section project promotion system ... ... ········ 104 My 2 Section Business and Performance Management Plan ... ... 106 My 3 Expected effect ... ... ... 111 My 4 section 2019 Yearly implementation plan ... ... ···· 112 My 6 Chapter Research Results and Utilization Plan ... ... 215 One. Research achievement ... ... ························· 215 2. Utilization plan (from the end date 6 Within months) ... ························ 216 My 7 Overseas science and technology information collected in the course of the chapter policy research service project ·············· 217 My 8 Chapter and other important changes ... ... ···· 218 My 9 Chapter Research Fund Usage Details and Researcher's Share Table ... ... 219 One. Research fund usage history ... ... ... 219 2. Research allocation table ... ... ··· 220 My 10 Chapter Bibliography ... ... ... 221 My 11 Chapter Attached Documents ... ... ... 223 enclosure. Business planning RFP draft ... ... ·· 224 -iv- Table of Contents < table 1> My 2 Car promotion strategy 4 Grand Promotion Strategy, 14 Dog Strategic Task ... ... 1 < table 2> Major megatrends of infectious diseases ... ... ·· 2 < table 3> Domestic infectious disease R&D And technical level in the field of international cooperation ... ... 4 < table 4> Technology level of key technologies by research field ... ... 4 < table 5> Overseas inflow · List of the Planning Committee of the Subcommittee for Infectious Diseases ... ... 12 < table 6> List of domestic unresolved infectious diseases subcommittee planning committee ... ··········· 12 < table 7> List of Planning Committees to Establish the Foundation for International Cooperation Research ... ... 13 < table 8> Major diseases in Korea ... ... ········ 19 < table 9> lately 5 year( '13~'17) Current status of deaths due to infectious diseases in Korea ... ······· 20 < table 10> `0̀3 Avian influenza outbreaks and virus types in Korea ... 21 < table 11> Risk analysis result by legal infectious disease ... ... 21 < table 12> Comprehensive assessment of the likelihood of occurrence and severity of overseas infectious diseases ... ············· 25 < table 13> Keywords used to extract tasks related to infectious diseases set ... ··········· 27 < table 14> lately 5 Year( '13~'17) Government total by year R&D And national infectious diseases R&D invest ························· 28 < table 15> 10 National Infectious Diseases by Major Area R&D invest ... ··························· 29 < table 16> 10 National Infectious Diseases by Ministry by Major Area R&D invest ... ············· 31 < table 17> Infectious Disease International Cooperation Research Investment by Ministry ... ················ 33 < table 18> One- EU GloPID-R Research objectives and research contents of international cooperation research on infectious diseases for participation ·········· 36 < table 19> Diagnosis and treatment of Zika virus among biomedical technology development projects ············ 39 < table 20> Infectious disease control global network construction task among social-adhered infectious disease source technology business ·············· 41 < table 21> Current Status of Infectious Disease International Cooperation Research Projects by Ministry ... ... 49 < table 22> USAID Infectious Disease International Cooperation Project ... ... 52 < table 23> JICA Representative infectious disease international cooperation support program ... ··········· 54 < table 24> SEAICRN Major roles by implementation system ... ... 59 < table 25> Major overseas networks owned in Korea (other than presenting technology demand) ... ... 82 < table 26> International cooperation on infectious diseases by department by year R&D Investment Status (Unit: KRW 100 million, %) ... 85 < table 27> Overview of Strategic Tasks for the Cross-Ministry Infectious Disease International Cooperation Research Project ... ·············· 94 < table 28> Strategic task One International Cooperation Research Objectives Against New Infectious Diseases Based in Asia ... 95 < table 29> Strategic task One Budget for international cooperation in response to new infectious diseases based in Asia ... 95 < table 30> Asian stronghold god · International Cooperation Research on Response to Variant Infectious Diseases RFP ... ... 96 < table 31> Strategic task 2 Africa South America Africa/South America Bases International Cooperation Research Objectives for Response to High Risk Infectious Diseases ··········· 97 < table 32> Strategic task 2 Africa South America Africa/South America Base International Cooperation Budget for Response to High Risk Infectious Diseases 97 < table 33> Center for International Cooperation in Response to High-Risk Infectious Diseases in Africa/South America ... 98 < table 34> Strategic task 3 Europe · International Cooperation Research Goals Overcoming Unresolved Infectious Diseases in North America ... 99 < table 35> Strategic task 3 Europe · International Cooperation Research Budget Overcoming Unresolved Infectious Diseases in North America ... 99 < table 36> Europe ․ Center for International Cooperation in Overcoming Unresolved Infectious Diseases in North America RFP ... 100 -v- < table 37> Strategic task 4 Research goal of collecting domestic and foreign resource information and establishing sharing infrastructure ················ 101 < table 38> Strategic task 4 Research budget for collecting and sharing domestic and overseas resource information ... 101 < table 39> domestic · Establishment of infrastructure for collecting and sharing other resource information RFP ... ... 102 < table 40> Evaluation index for selection evaluation (draft) ... ... ... 106 < table 41> Evaluation index for annual evaluation (draft) ... ... ... 107 < table 42> Evaluation index for final evaluation (draft) ... ... ... 109 < table 43> Necessary elements for project management and major review contents (draft) ... ······· 110 < table 44> Expected effect of business ... ... ... 111 -vi- Table of contents [ Drawing One] domestic '13~'17 Infectious disease outbreaks ... ... 3 [ Drawing 2] Research project promotion system ... ... ... 14 [ Drawing 3] Contents of research by step to promote this task ... ... 15 [ Drawing 4] International cooperation project planning procedure for infectious diseases ... ... 16 [ Drawing 5] Domestic infectious disease outbreak status ... ... ············ 18 [ Drawing 8] Distribution of infectious disease R&D investment by department ( '13 - '17 year) ... ············· 28 [ Drawing 9] Diseases with high domestic R&D investment (in descending order of investment) ... ············ 32 [ Drawing 10] Infectious Disease International Cooperation Research Investment (KRW 100 million) ... ... 33 [ Drawing 12] JICA Operating model ... ... ... 54 [ Drawing 13] e-ASIA Joint Research Program (JRP) summary ... ... 56 [ Drawing 14] International Centers of Excellence for Malaria Research (ICEMR) Center distribution status 57 [ Drawing 15] SEAICRN Organization chart ... ... ... 58 [ Drawing 16] Infectious disease field by department and regional base R&D Current status of international cooperation projects ... 87 [ Drawing 17] Existing infectious disease R&D Differentiation from business ... ... 89 [ Drawing 18] International cooperation for infectious diseases across ministries R&D Business 3 Planning direction ... ... 90 [ Drawing 19] Setting the direction of business promotion ... ... ········ 92 [ Drawing 20] Business promotion direction (plan) ... ... ... 93 [ Drawing 21] Directions for each strategic task by promoting international cooperation projects for infectious diseases across ministries ... 103 [ Drawing 22] Business promotion system and operation method ... ... 104 [ Drawing 23] Business promotion system (plan) ... ... ·············· 105 -vii- Report summary [2019] For implementing the national infectious disease crisis response strategy Research Project Name Pan-Ministry R&D Implementation plan and new business planning research Index word Infectious disease, implementation plan, international joint research, ministry, international cooperation Host research institute Co., Ltd. Knowledge Works Senior Researcher Jaehee Lee Research period July 10, 2018 – March 9, 2019 One. Background and necessity ○ My 2 We are checking the annual performance and plans of the strategy for developing technologies to respond to the national infectious disease crisis 2019 Need to prepare annual implementation plan ○ My 2 It is necessary to plan new international cooperation projects for the smooth implementation of the primary promotion strategy. 2. Results of research promotion ○ 3 Large Focus Area, 7 Derivation of major promotion tasks 3. Management plan for new business ○ General coordination and management centered on the cross-ministerial infectious disease response research and development promotion committee, but entrusted operation with a cross-ministerial working-level council and business group -( Infectious Disease Response R&D Promotion Committee) General coordination of the project and evaluation and management of the project -( Pan-Ministry Working Group) Ministry of Infectious Diseases R&D Provision of information, coordination of research and development between ministries and practices -( Project Team) Responsible for overall business operation such as task selection, evaluation, and management -viii- Summary [2019] A Study on the Research Plan for the Drive Plan of Multi-Agency Title of Project R&D Program to Implement the National Responding strategy of Infectious Diseases infectious disease, implementation plan, international joint R&D, Key Words trans-government R&D project Institute knowledgeworks Project Leader Lee Jae hee Project Period July 10, 2018 – March 9, 2019 1. Backgrounds and objective ○ The 2nd National R&D strategic plan for Infectious disease Response was established in 2016 ○ It is necessary to make new trans-government R&D program that strengthen national ability for infectious disease prevention and international cooperation ○ Our goal is 1) planning of trans-governance R&D program related international R&D cooperation for infectious disease 2) an establishment of 2nd National R&D strategic plan 2019 program implementation plan 2. Result ○ 3 focused area, 7 strategic project was established for priority implementation ○ -ix- Policy Research Service Project Research Results Section 1 Goal 1. Background and necessity of research ☐ My 2 Secondary Infectious Disease Crisis Response Technology Development Promotion Strategy '17~'21)( Below. 2 1st promotion strategy) suggests international cooperation for infectious diseases And it needs to be promoted smoothly. One) ○ My 2 Car promotion strategy 4 Out of strategy “ Strengthening international cooperation and research infrastructure ” Is included, and the following 4 Presenting dog strategic tasks - Promotion of international joint research for each stage of infectious disease research - Establish a network of overseas research institutes and strengthen cooperation with international organizations - science Technology ICT Enhancing the ability to respond to infectious diseases and strengthening the research period - Establishment of a system for nurturing experts in responding to infectious diseases < table 1> My 2 Car promotion strategy 4 Grand Promotion Strategy, 14 Dog Strategic Task 4 Grand Promotion Strategy 14 Grand Strategic Task One. With the national defense system Ⓥ Throughout the entire cycle of the national defense system R&D support Associated infectious disease R&D Ⓥ Pandemic (pandemic) infectious disease field response technology development expansion Strengthening support Ⓥ Focused on national infectious disease management technology R&D propel( 73 Dog key technology) Ⓥ Infectious diseases R&D Executive · Establish a system of coordination functions 2. Infectious diseases R&D Interdepartmental Ⓥ Infectious diseases of each department R&D Establish a regular monitoring system Linkage and Ministry Ⓥ Research institute · Industry · hospital · Establish a cooperation system between quarantine agencies Executive · Strengthening coordination Ⓥ Division of roles by ministry and expansion of ministry cooperation Ⓥ Infectious diseases R&D Government to secure capacity and prevent spread · Establishment of private cooperation system · Early 3. Min · Tube cooperation and Ⓥ overcoming of infectious diseases and creation of industrial performance by promoting government cooperation projects R&D Strengthen performance management Ⓥ 「 Infectious Disease Response Research and Development Promotion Committee 」 Promotion of international joint research for Ⓥ each stage of research on infectious diseases 4. International cooperation and Ⓥ Building networks with overseas research institutes and strengthening cooperation with international organizations Strengthening research infrastructure Ⓥ science Technology ICT Utilizing infectious disease response capabilities and strengthening research base Establishment of Ⓥ a system for training experts to respond to infectious diseases One) My 2 Second National Infectious Disease Crisis Response Technology Development Promotion Strategy ( '17~'21), National Science and Technology Council, 2016 - One - ☐ As major research projects related to international cooperation are expected to end, follow-up measures are required. ○ Seoul National University Global Infectious Disease Center, which established an international cooperation network for infectious diseases by the Ministry of Science and ICT (GCID), Inje University Korea Institute of Infectious Diseases International Cooperation ( KOICID) Assignment '19 year, '20 As each year is expected to end, it is necessary to consider the outcome of the subsequent linkage. ☐ The need for international cooperation to prepare for global infectious diseases is increasing. ○ With the increase in international mobility, international cooperation is more active than ever in responding to infectious diseases, increasing the possibility of international cooperation research planning. ○ Multilateralization related to infectious diseases by raising the national status in the international community WHO And WPRO General Assembly, G20, Global Fund, Korea, China and Japan) and bilateral cooperation ( SOFA Etc) continuous increase - Infectious disease management international contribution ( 15 year 18 Billion → 18 year 24 Billion), International Vaccine Research Institute ( 16 year 57 Billion → 18 year 112 Billions of dollars) increase ODA) Need for systematic management ○ USA( '10 Year), China ( '17 Year), strengthening international cooperation by establishing an international cooperation center within the Centers for Disease Control and Prevention in Northern Europe. - Japan, China, etc., are dispatched to countries with high risk of infectious diseases (Africa, Middle East, Central and South America, etc.) by fostering experts who can play an active part in the quality international community · arrangement ☐ It is necessary to strengthen proactive preparation for the increase in the risk of infectious diseases due to environmental changes, etc. ○ Infectious diseases in Korea are on the rise recently, and infectious diseases that have not been experienced in Korea due to climate change and increased global mobility are also occurring in Korea. < table 2> Major megatrends of infectious diseases Global megatrend Main Content Ÿ 24 You can travel anywhere in the world within hours, Increased global mobility Increase in trade moves pathogens together Ÿ Increased mobility due to the development of logistics/transportation means such as aviation, shipping and railroad Ÿ Mega City( 1,000 Over 10,000), the population concentration is early after the outbreak of infectious diseases. Megacityization Risk of spread Climate warming Ÿ Global warming increases the spread of infectious diseases caused by mosquitoes and other diseases. Ÿ Massive increase in livestock production is a weakening of the animal's immune system and Livestock industry Spread of acquired common diseases -2- - Prior information on infectious diseases and related pathogen resources need to be secured before entering Korea - Recently in Korea 5 Annual infectious diseases '13 year 10 Per 10,000 people 148.4 People from onset '17 year 295.5 Opened by people Average 18.8% increase - The main cause of the rapid increase in infectious diseases is the continuous increase of indigenous infectious diseases such as water supply, scarlet fever, and mumps. [ Drawing One] domestic '13~'17 Infectious disease outbreaks ☐ Urgently needed to bridge the technological gap with advanced countries through international joint research 2) ○ As the technology level related to infectious diseases is low, it is necessary to quickly pursue technology through international joint research. -'16 year KISTEP As a result of domestic technology level survey, the field of infectious diseases compared to the world's top technology country (USA) 70.1% At the technical level '14 year 75.6% Rated lower than - The infectious disease field has a lower technical level than the entire domestic, bio, and medical fields -'16 As a result of surveying the technology level of infectious diseases in Korea targeting experts in the Infectious Disease Research Forum in 2012, compared to the world's highest technology (USA) 65.5% And among them, the field of international cooperation 50.0% It appears as low compared to the basis/mechanism, diagnosis, etc. ※ Basic/mechanism 65.6%, monitoring forecast 61.3%, etc. 2) 2016 Yearly Technology Level Assessment, 2017, Korea Advanced Institute of Science and Technology Evaluation -3- < table 3> Domestic infectious disease R&D And technical level in the field of international cooperation Technology level related to infectious diseases in Korea Technology level in the field of international cooperation for infectious diseases < table 4> Technology level of key technologies by research field Research field Key technology name Technology level (%) 4-6. New influenza virus infection pathology and pathogen morphological analysis technology 30 Foundation/ 5-5. Study on the mechanism and characteristics of antibiotic resistance between human-animal-environment 50 Mechanism( 4 dog) 7-2. Research on chronic viral infection incidence and disease progression mechanisms 60 10-3. Bioterrorist pathogen vaccine · Pathogenesis/basic research for the development of therapeutic agents 60 1-2. National surveillance system ( K_EPINET) Upgrade and secure pathogen resources 50 1-3. Establishment of a system to prevent hospital infection of new and unknown infectious diseases 50 3-1. One Health Development of a monitoring system for the occurrence of common infectious diseases 60 Surveillance, prediction 4-1. Severe influenza and acute respiratory infections ( SARI) Integrated monitoring system 60 And mechanics 5-1. One-Health Concept of antibiotic resistance monitoring 40 (9 dog) 5-2. National antibiotic use survey 60 8-1. Infectious disease advance and regional real-time monitoring system and prediction model development 50 9-7. Vaccine adverse reaction research and response system development 52.5 10-1. Research on biological surveillance system for response to biological terrorism 55 4-3. Risk assessment for influenza virus to prepare for pandemic 60 Diagnosis( 2 dog) 10-5. Rapid bioterrorism pathogen · High sensitivity diagnosis · Detection technology development 60 1-5. Development of new and unknown infectious diseases treatment 25 1-6. Vaccine for new and unknown infectious diseases 25 1-7. Safety for approval for diagnosis/vaccine/treatment ․ effectiveness ․ Quality evaluation technology development 50 Vaccine and 2-3. Development of treatment for infectious diseases of climate change 50 remedy 3-6. Development of vaccine/treatment candidate materials and improvement of treatment/prevention methods · Development 52.5 (9 dog) 4-7. Development of antiviral drugs targeting new targets of influenza virus 50 6-3. Development of basic technology for resistant tuberculosis treatment and vaccine 60 7-4. Chronic virus infection vaccine, treatment and evaluation technology development 60 10-4. Bioterrorism pathogen vaccine/treatment safety ․ effectiveness ․ Quality evaluation technology development 60 Prevention/ 2-7. Research on climate change infectious disease vector control technology development 20 Control ( One dog) Policy( One dog) 9-1. Management, evaluation and improvement of infectious diseases subject to national vaccination 60 1-8. Nurturing infectious disease experts and strengthening public-private, international cooperation networks 50 2-8. Min · Establishment of public and international cooperation networks 50 infra 7-5. Establish research infrastructure to overcome chronic viral infection 60 (5 dog) 8-4. Ministry for rapid disaster response · Municipality · Building infrastructure for cooperation with the private sector 50 8-8. Establishment of research resources and information infrastructure for infectious disease research 60 -4- ☐ International cooperation R&D Systematic · Insufficient synergy effect due to lack of strategic execution ○ Each ministry individually conducts research on international cooperation tailored to its mission, 〮 Lack of strategic execution - The Ministry of Science and ICT, the Ministry of Health and Welfare, the Ministry of Food, Agriculture, Forestry, and Food, and the Ministry of Environment, etc., individually conduct international cooperation research through research and development projects or the institution itself - It is a structure that makes it difficult for national synergy effects to appear because only exchanges between individual researchers are conducted. Considering the capabilities of individual researchers, there is a limit to establishing a cooperative network with foreign national institutions and universities. 2. Research goals and contents ☐ For advanced infectious disease crisis response R&D International Cooperation Multi-Ministry Project Planning ○ Identify and plan tasks necessary to strengthen research capabilities related to infectious diseases that are insufficient in Korea ○ To strengthen research infrastructure such as international cooperation to strengthen countermeasures against infectious diseases “ Infectious diseases R&D Multi-Ministry Joint Planning Project for International Cooperation ” plan ☐ My 2 Of the second national infectious disease crisis response strategy 2019 Yearly implementation plan (draft) prepared ○ My 2 For the smooth execution of the next promotion strategy, the annual performance and plan for the next year are checked, and the cooperation and performance use of related ministries are strengthened end. Grounds for business promotion ☐ The promotion of this project is 2 Primary Plan for Prevention and Management of Primary Infectious Diseases 2 Second National Infectious Disease Crisis Response Technology Development Promotion Exhibition Matches the outline -5- My 2 Primary infectious disease prevention management basic plan ( '18~'22) ☐ A safe society without worrying about infectious diseases has been set as the vision, and strategies related to international cooperation are presented. ○ Focused task ⑤ Reinforcing infectious disease response and preparedness infrastructure 5-5. Establish a foundation for international cooperation and present human resources training My 2 Primary infectious disease prevention management basic plan ( '18~'22) Of international cooperation infrastructure and manpower development ☐ 5-5. Establishment of infrastructure for international cooperation and human resource development ○ ( Establishment of foundation) Establishment of systematic management base through expansion of dedicated personnel for international cooperation -WHO Systematic management of agendas and performance of international organizations meetings, Korea, China, Japan, etc. ODA Contributing to the strengthening of national capabilities through internal project management, KOICA And KOFIH Promotion of regular information exchange with international development promotion organizations such as ○ ( Dedicated organization) Analysis of quality-based crisis in the mid to long term · Separation of International Cooperation Division into International Cooperation Division · New establishment and international cooperation center establishment promotion ☐ Establishment of information sharing system for international cooperation and systematic management ○ ( Manpower development) Completion of education and training for domestic experts such as epidemiological investigators and GOARN( Global pandemic warning and response network) as an expert, improving domestic infectious disease response capabilities and contributing to international health ○ ( International Exchange) Short-term to overseas infectious disease management institutions · Training international infectious disease management experts through organ dispatch and expansion of dispatch agencies* ※ US CDC (1 person), WPRO (1 person) → WHO headquarters, IVI, Japan NIID, China CDC, Africa CDC, etc. ○ ( Overseas support) Highly pathogenic in Africa, Middle East, etc. · Establishment of a system for dispatching professional personnel for technical support and project management to areas where new infectious diseases occur -6- My 2 Second National Infectious Disease Crisis Response Technology Development Promotion Strategy ( '17~'21) Vision and strategy ☐ Vision and strategy ○ ( Vision) Realize a healthy and safe country without worrying about infectious diseases ○ (4 Grand Promotion Strategy) ① Infectious diseases linked to the national defense system R&D Strengthening support, ② Min · Tube cooperation and R&D Strengthening performance management, ③ Infectious diseases R&D Linkage between ministries and general management of all ministries · Reinforcement, ④ Strengthening international cooperation and research infrastructure -7- My 2 Secondary national infectious disease crisis response technology development promotion strategy ( '17~'21) Content of Ⓥ Promotion of international joint research for each stage of infectious disease research ○ Strengthening joint research projects through global partnership for each stage of infectious disease research ※ Infectious disease R&D in cooperation with WHO WPRO through ODA project -( Basic/Mechanism) Advanced Research Information and New ․ Sharing such as finding out new mechanisms of infectious diseases -( etc.) Diagnosis) Cooperation such as research on diagnosis method development using samples from overseas (Middle East, Southeast Asia, -( Treatment) Joint research such as multinational clinical trials for therapeutic agents -( Vaccine) Joint research on regulatory science such as quality evaluation with overseas regulatory agencies -( consortium Prevention of diffusion) domestic and foreign research institutes ․ Organization and operation of corporate Ⓥ Building networks with overseas research institutes and strengthening cooperation with international organizations ○ God ․ Establish a cooperative system such as the area where infectious diseases occur and the regular network ※ Information on infectious diseases, early acquisition and characterization of pathogen resources, diagnosis, treatment technology, vaccine, etc. Promotion of old exchange and signing of MOU ○ Leading participation in the global infectious disease network through bilateral multilateral cooperation ※ '17. The 4th Global Health and Security Initiative (GHSA) is scheduled to act as a chairman and the Centers for Disease Control and Prevention consults WHO R&D Blueprint, which participated as a member, will be announced (June, 2016) ○ International vaccine research institute and public vaccine development ․ Establish a cooperation system between support centers ※ ( Joint response to infectious diseases) Joint development of vaccines based on information on major infectious diseases Car and norovirus), etc. ※ ( Globalization of the vaccine industry) Transfer of vaccine production technology to Korean companies and preliminary evaluation of the World Health Organization Support for entry into the global public vaccine market by acquiring WHO PQ ○ WHO Cooperation Center ( Collaborating Center, CC) Designation promotion ※ Based on the experience of the Korea Centers for Disease Control and Prevention and the international cooperation project promoted by the National Institute of Health 2 - 3 years Strengthen cooperation with international organizations by promoting designation of the WHO Cooperation Center Ⓥ science Technology ․ ICT To improve the ability to respond to infectious diseases and strengthen the research base ○ ( Basic research) Perform basic research related to infectious diseases through ministry-specific projects, etc. ※ AI infection spread monitoring, norovirus rapid detection, influenza general-purpose vaccine and immune diagnosis system Tem, superbacterial proliferation control study, anti-dengue virus proliferation inhibition study, etc. ○ ( Convergence research) Infectious disease response technology centered on research institutes and research teams with research facilities related to infectious diseases -8- Convergence research support for development ○ (ICT Utilization) Active use of information and communication technology to improve field response capabilities and link with industrial development and job creation ※ Prediction and monitoring technology for the spread of infectious disease using location-based technology, Mobile measurement and management technology for management, etc. ○ ( Activation of research) Enhancement of research accessibility by sharing infectious disease research resources (research products such as pathogens, antigen proteins, genes, etc.) ※ Guidelines for researchers to use the facilities in cooperation with the establishment of a biosafety level 3 research facility e. Training (gives authority and responsibility for facility opening and experimentation) ※ Improvement of procedures such as relaxation of research approval for rapid research execution Ⓥ Establishment of training system for experts in responding to infectious diseases ○ Nurturing research experts to respond to infectious diseases - Infectious disease research experts DB Establishment and utilization plan, strengthen cooperation with human resources training institutions such as domestic medical schools ※ Promote training young researchers such as basic infectious diseases (microbiology), clinical and epidemiological experts ○ Development and expansion of specialized training programs for infectious diseases - Establish an education system using domestic specialized institutions such as the Health and Welfare Human Resources Development Institute ※ Sharing experiences on the surveillance system and epidemiological investigation of outbreaks of group infectious diseases such as Ebola and MERS, Non-response related education ○ Preparation of infectious disease specialist training plans through international cooperation - England( PHE) USA( CDC NIH) EU (ECDC) Nurturing infectious disease experts through exchange and cooperation with infectious disease national organizations and medical schools in major countries, etc.* ※ Infectious disease basics (microbiology), clinical and epidemiological researcher training, professional manpower DB construction - Experts in acquiring new variant pathogen response technology, international organizations ( WHO Etc.) dispatch -9- I. The progress of the plan ☐ This planning study was carried out through the following process. ○ Report on the initiation of this project (` 18. 7. 24) - Infectious Disease Research Forum 10 Large Subcommittee Chair One International cooperation infectious diseases at the next meeting R&D Business planning and 2019 Propose a plan to establish an annual implementation plan and collect opinions on future directions ○ One Conducted the primary technology demand survey (̀ 18. 7. 30 ~ '18. 8. 13) - Infectious Disease Forum 10 To identify the need for international cooperation research on infectious diseases and the demand for technology development contents for subcommittees belonging to the major divisions and practitioners of relevant ministries. ○ Working-level meeting of the Ministry of Infectious Disease Response Research and Development Promotion Committee ( '18. 8. 16.) - Request for cooperation to understand the current status of infectious disease international cooperation projects or tasks currently being carried out by each ministry, and the contents of the agency's own implementation - Consideration of a method of supporting international cooperation research currently being promoted by each ministry - Consider creating and operating a separate organization that can manage international cooperation research on infectious diseases ○ Infectious Disease Research Forum 10 Large Subcommittee Chair 2 Tea meeting ( '18. 8. 31.) - One Announcement and opinion collection related to the primary technology demand survey - Rather than basic/mechanical research, it is necessary to promote clinical/verification research, etc. - Need for detailed analysis of existing domestic infectious diseases international cooperation research projects and projects ○ My 6 Held the annual Infectious Disease Research Forum (collecting opinions on international cooperation research) ( '18. 9. 6.) - Collecting opinions of researchers on international cooperation research on infectious diseases ○ Planning committee division and members ( '18. 10.) - Overseas inflow · Variety of infectious diseases, unresolved infectious diseases in Korea, establishment of international cooperation research base, 3 The planning committee consists of individual divisions ○ One car, 2 Second planning committee meeting ( One Car: 11.14/20, 2 Car: 12.14) ('18.11.) - One The second meeting is conducted by each division, 2 Tea meeting 1, 2, 3 Proceed in collaboration with - One The next meeting introduces the purpose of planning, collecting opinions on the direction of the project, and the role of future subcommittees. - 2 The next meeting is to share the content of demand for technology development suggested by each researcher, and the schedule for future promotion. -10- ○ 2 Conducted the primary technology demand survey (̀ 18. 12. 15 ~ '19. 1.4) - Demand survey conducted for members of the Expert Planning Committee and researchers belonging to the pool of health care experts registered in the Health Industry Promotion Agency, etc. - Presenting experiences and difficulties of international cooperation research on infectious diseases in the past, and international cooperation research and development tasks ○ Infectious Disease Research Forum 10 Large Subcommittee Chair 3 Tea meeting ( '18. 12. 19.) - Report on the progress of international cooperation projects for infectious diseases across ministries and collect opinions on future directions ○ Working-level meeting of the Ministry of Infectious Disease Response Research and Development Promotion Committee ( '19. 1.24.) - Collecting opinions on the current status and future direction of the planning of the international cooperation project for infectious diseases of the ministry ○ Planning Committee 4 Tea meeting ( '19. 2. 28.) - Report on the progress of international cooperation projects for infectious diseases across ministries and collect opinions on future directions ○ Detailed research content RFP Write and review ( '19. 3. 18.) - International Cooperation for Infectious Diseases by Ministry RFP Request an expert for writing and review the Centers for Disease Control and Prevention ○ One Primary Infectious Disease Research Planning Committee ( '19. 3. 28.) - Report on the plans for international cooperation projects for infectious diseases across ministries and collect opinions on future directions ○ One Second, the Ministry of Infectious Disease Response Research and Development Promotion Committee ( '19. 4. 30.) - Report on the progress of international cooperation projects for infectious diseases across ministries and collect opinions on future directions -11- < table 5> Overseas inflow · List of the Planning Committee of the Subcommittee for Infectious Diseases Serial number name Affiliation (department) position One Youngmi Ji Center for Disease Control and Prevention Infectious Disease Research Center Center head (chairperson) 2 Park Man-seong Korea University College of Medicine Professor 3 Seonghan Kim Department of Infectious Medicine, University of Ulsan College of Medicine Professor 4 Joonseop Yeom Yonsei University Infectious Medicine Professor 5 Kim Dongmin Chosun University Infectious Medicine Professor 6 Seongjun Kim Korea Research Institute of Chemical Technology Novel Virus Convergence Research Center Senior Researcher 7 Park Hyung-soon Co., Ltd. Asta Senior Research Fellow 8 Jaehong Kim Seoul National University College of Veterinary Medicine Professor 9 Youngrak Cho Co., Ltd. Legochem Bioscience Head of Development Division 10 Jaebum Joo Hanyang University Department of Bio-Nano Engineering Professor 11 Beomseok Kim Chonbuk National University College of Veterinary Medicine Professor 12 Go Hyun-jung Kangwon National University College of Pharmacy Professor 13 Lim Dong-gyun National Medical Center Public Health Research Institute Director 14 Jeongho Kim Co., Ltd. Bio Note Research Institute Director 15 Eunhwa Choi Seoul National University College of Medicine Pediatrics Professor 16 Kwak Lee-kyung Inje University College of Medicine Associate Professor 17 Abuse Kogen Biotech CEO 18 Wooyoung Choi Virus Analysis Division, Center for Disease Control and Prevention Researcher 19 Jooyeon Lee Center for Disease Control and Prevention, Research Division for New Infectious Diseases Manager (secretary) < table 6> List of domestic unresolved infectious diseases subcommittee planning committee Serial number name Affiliation (department) position One Gyunhwan Kim Konkuk University College of Medicine Professor (Chairman) 2 Eui-cheol Shin Catholic University College of Medicine Professor 3 Lee Je-cheol Kyungpook National University College of Medicine Professor 4 Yongdongeun Yonsei University College of Medicine Professor 5 Noh Seong-gu Pimed Bio representation 6 Ryu Choongmin Korea Research Institute of Bioscience and Biotechnology (New Convergence Cluster) Senior Researcher 7 Cho Eun-kyung Chungnam National University College of Medicine Professor 8 Joonyong Choi Yonsei University College of Medicine, Department of Infectious Medicine Professor 9 Heo Jin Chonbuk National University College of Veterinary Medicine Professor 10 Jaeseung Kim Co., Ltd. Curiant Research Institute Director 11 Choi Byung-seon Virus Disease Research Division, Center for Disease Control and Prevention Researcher 12 Kwangjun Lee Korea Centers for Disease Control and Prevention Researcher 13 Eunjoo Chu Soonchunhyang University College of Medicine Associate Professor 14 Kwon Hyun-hee Daegu Catholic Medical University Professor 15 Lee Mi-suk Kyunghee University College of Medicine Professor 16 Hyukmin Lee Yonsei University College of Medicine Professor 17 Seongsoon Kim Bacterial Disease Research Division, Centers for Disease Control and Prevention Manager (secretary) -12- < table 7> List of Planning Committees to Establish the Foundation for International Cooperation Research Serial number name Affiliation (department) position One Ryu Wangsik Institut Pasteur Korea Research Institute Director 2 Seongmin Kim Inje University College of Medicine Haeundae Paik Hospital Professor 3 Hwang Eungsu Department of Microbiology, Seoul National University College of Medicine Professor 4 Mihyeon Kim Korea Research Institute of Chemical Technology Senior Researcher 5 Song Mangi International Vaccine Research Institute Senior Researcher 6 Kim Kyunghyun Korea University Department of Bioinformatics Engineering Professor 7 Younggi Choi Chungbuk National University Professor 8 Kim Sang-il Catholic University College of Medicine Professor 9 Jang In-jin Seoul National University Professor 10 Song Soo-yeon Korea International Cooperation Agency ( KOICA) Specialist 11 Shin Seongjae Yonsei University College of Medicine Professor 12 Hyezone Lee International Tuberculosis Research Institute Director 13 Sungho Choi Chung-Ang University College of Medicine Associate Professor 14 Yong Tae-soon Yonsei University College of Medicine Professor 15 Justice Chungbuk National University Professor 16 Jeong Yong-pil Seoul Asan Hospital Associate Professor 17 Bae Hongcheol Ministry of Health and Welfare, Health and Medical Technology Development Division secretary 18 Lee Sun-kyu Center for Disease Control and Prevention, Crisis Analysis and International Cooperation DivisionExaggeration 19 Eunjung Park secretary Center for Disease Control and Prevention, Crisis Analysis and International Cooperation Division 20 Jeongsik Yoo Vaccine Research Division, Center for Disease Control and Prevention Researcher 21 Choi Young-sil Center for Disease Control and Prevention Pathogen Resource Management TF team Team Leader 22 Eunsoo Shim Ministry of Environment Biodiversity Performance secretary 23 Gardening National Institute of Environmental Sciences Biosafety Research Team Team Leader 24 Goo-kyung Ministry of Science and ICT, Bioeconomic Team Team Leader 25 Hyungok Jeon Biologics Research Division, Korea Food and Drug Administration Researcher 26 Taehyun Bae Ministry of Agriculture, Food and Rural Affairs, Science and Technology Policy Division secretary 27 Kim Heejin Agriculture, Forestry and Livestock Quarantine Division Research Planning Division Researcher 28 Jeongmin Lee Center for Disease Control and Prevention Research Planning Division Researcher (secretary) -13- 4. Project planning system and procedure end. Business planning establishment system ☐ This project plan is promoted in the form of a research service by Knowledge Works Co., Ltd., an organization that conducts the project under the management of the Centers for Disease Control and Prevention. ○ ( Korea Centers for Disease Control and Prevention) Presenting needs for tasks, supporting data related to task performance, organizing the internal committee of the Korea Centers for Disease Control and Prevention, and working-level committees of other ministries, reviewing, approving, and establishing implementation plans ○ ( Internal opportunity TF) Presenting R&D demand, reviewing the contents of the planning report, etc. ○ ( Practitioner's Committee) Providing research and development demand, providing data on the current status of research on infectious disease international cooperation by each department, presenting opinions on project operation plans, reviewing the contents of the planning report, writing the contents of the implementation plan - The working-level committee consists of working-level workers in charge of infectious disease related projects from the Ministry of Science and Technology, the Ministry of Welfare, the Center for Disease Control, the Ministry of Industry, the Ministry of Food and Drug Safety, the Ministry of Environment, and the Ministry of Agriculture, Forestry, and Food. ○ ( Infectious Disease Forum Subcommittee Chair) 3 Review opinions of individual subcommittees and planning committees, set the direction of project promotion, etc. ○ ( Subcommittee) Presenting technology demand, presenting points of interest in international cooperation project planning, presenting difficulties of existing infectious disease international cooperation research, presenting directions for international cooperation research in infectious disease ○ ( Research institute) Project promotion strategy and detailed planning, operation of the committee, drawing out and submitting results according to the execution of project planning, and support in preparation for establishment of implementation plans [ Drawing 2] Research project promotion system -14- I. Business plan establishment procedure ☐ This task is as follows 3 It consists of steps and proceeds ○ ( Trend Analysis) Domestic infectious diseases · Other trend analysis - Analysis of domestic infectious disease outbreaks and major issues in response to major infectious diseases - Analysis of international cooperation status of major overseas organizations - Domestic infectious disease R&D Investment and content, investment analysis related to international cooperation - Analysis of domestic infectious disease international cooperation projects, task analysis, research results and difficulties ○ (2019 Yearly implementation plan) 2018 Year performance and 2019 Preparation of annual implementation plan (draft) - Provide the form to the ministries, and 2018 Analysis of annual performance and performance -10 Analyzing the degree of achievement of performance targets by major areas -2019 (draft) Establishment of annual implementation plan ○ ( International cooperation project planning) Planning a new international cooperation project for infectious diseases - Research and development demand survey on international cooperation in infectious diseases by experts and related ministries - Selection of candidate tasks related to international cooperation based on demand survey - Establish detailed plans (drafts) for each task [ Drawing 3] Contents of research by step to promote this task -15- ☐ For the planning of international cooperation projects, 4 Consists of four modules to perform tasks ○ ( Environmental analysis) Status of infectious diseases in Korea, R&D Research investments, major achievements, and researcher demand - Analysis of the occurrence and response status of domestic infectious diseases through literature analysis such as white papers on infectious diseases in Korea and guidelines for responding to infectious diseases -NTIS Analyzing the current status of investment in international cooperation for infectious diseases in Korea through data analysis, and surveying the current status of international cooperation projects for infectious diseases undertaken by the agency for practitioners of ministries. - 2 Analysis of major achievements of past international cooperation studies based on the contents of the implementation plan of the second promotion strategy - USA NIH Affiliated infectious disease research institute NIAID Analysis of international cooperation research promotion status and cooperation - Conducting research on technology demand for researchers through online and email ○ ( Direction setting) Establish the direction of business promotion based on the implications derived through domestic and international environmental analysis ○ ( Derivation of detailed tasks) Establishes the vision/goals/focused areas of the project through the content of the technology demand survey and the expert planning committee, and establishes detailed plans (drafts) for each task accordingly - Based on the content of the technology demand survey, we derive major focus tasks ○ ( Expected Effects) Presenting the expected effects of policy, society and economy [ Drawing 4] International cooperation project planning procedure for infectious diseases -16- Section 2 Achievement of Goals and Contribution to Related Fields ☐ Planning of international cooperation research and development projects for new infectious diseases by multi-Ministry ○ (One Stage domestic and international trend analysis) 2019 In order to establish an annual implementation plan and plan international cooperation projects for multiple ministries, · Analysis of external trends - Analysis of domestic infectious disease outbreaks and major issues related to research - Analysis of the status of international cooperation in infectious diseases of each ministry and major institutions - Domestic infectious disease R&D Analysis of investment status in investment and international cooperation research ○ (2 Stage implementation plan establishment) 2 Car promotion strategy 2019 Review the contents of the existing implementation plan to establish an annual implementation plan, 2019 Establish an implementation plan through the establishment of the implementation plan preparation form and the collection of the contents of each department -2018 Review the contents of the implementation plan established in 2012 and the needs for supplementation, and collect opinions on improvements of individual ministries that need to fill out the form - Checking and improving the preparation form for writing the implementation plan - Based on what the ministry wrote 2019 Establish an annual implementation plan - The organization performing this project Co., Ltd. Knowledge Works 2019 Guidelines for establishing an annual implementation plan and NTIS Data analysis is carried out, and the Centers for Disease Control and Prevention prepares an implementation plan (draft) and provides it to the relevant department. Co., Ltd. Knowledge Works 2019 Establish an annual implementation plan ○ (3 Stage Multi-Ministry International Cooperation Project Planning) Deduce major R&D tasks through analysis of domestic issues related to international cooperation and technology demand survey - Review of existing domestic infectious diseases international cooperation achievements, difficulties in project promotion and major issues - Research on the need for international cooperation in infectious diseases and countries in need of cooperative research and demand for technology development - Based on the technical demand survey to experts, the direction of the project is set, and the vision, goals, and focus areas of the project are set - Infectious disease international cooperation projects R&D Derive an assignment ☐ “ My 2 Strategies for developing technology to respond to the crisis of primary infectious diseases ” of 2019 Contribution to drafting the annual implementation plan ○ 2019 Provide the form to the relevant department for the yearly implementation plan ○ Request for preparation of related achievements and future plans for each department ○ My 2 Car implementation strategy 2 As years have passed 10 Major Area of Focus, 73 Investment performance by each key technology, 10 Newly inspecting the status of achievement of performance targets for each field -17- Section 1 Current Status of Infectious Diseases in Korea ☐ lately 5 The number of infectious diseases in Korea increases rapidly every year. ○ '13 year 10 Per 10,000 people 148.4 People from generation '17 year 10 Per 10,000 people 295.5 Annual average by occurrence 18.8% Infectious disease Increase in number ○ Chickenpox, scarlet fever, mumps, C Hepatitis, A Hepatitis, etc. is the cause of rapid increase - Last 5 Chickenpox medicine per year 26 10,000 cases, tuberculosis drugs 16 10,000 cases, mumps drug 10 Ten thousand occurrences, among the new infectious diseases influencing overseas, tsutsugamushi is also weak. 5 10,000 occurrences Source: 2017 Annual Report on Infectious Diseases, Korea Centers for Disease Control and Prevention [ Drawing 5] Domestic infectious disease outbreak status -18- ☐ Chickenpox, tuberculosis, and mumps are consistently high in Korea. ○ '16 Year by year One Infectious diseases that occur in more than 10,000 people include chickenpox, tuberculosis, mumps, tsutsuga musculus disease, scarlet fever. 5 Dog -1,000 Infectious diseases that occur more than one person A Hepatitis, syphilis, acquired immunodeficiency syndrome 3 dog -300 Malaria, nephrotic hemorrhagic fever, pneumococcus B Hepatitis, dengue fever 5 dog ○ scarlet fever, A Hepatitis and mumps occur more frequently in Korea, and the recent increase rate has been shown to be high. - On the other hand, B Hepatitis and tuberculosis still have a large number of cases, but the incidence has recently turned to a decline. < table 8> Major diseases in Korea ( Unit: number of reports) Infectious diseases 2012 2013 2014 2015 2016 total varicella 27,763 37,361 44,450 46,330 54,060 209,964 Tuberculosis 39,545 36,089 34,869 32,181 30,892 173,576 Mumps 7,492 17,024 25,286 23,448 17,057 90,307 Tsutsugamushi 8,604 10,365 8,130 9,513 11,105 47,717 Multidrug-resistant Asinetobacter Baumani 13,606 17,249 - - - 30,855 (MRAB) scarlet fever 968 3,678 5,809 7,002 11,911 29,368 C Hepatitis 4,272 3,703 4,126 4,609 6,372 23,082 B Hepatitis 2,753 3,387 4,115 3,666 359 14,280 influenza 3,550 1,773 2,011 1,614 1,764 10,712 A Hepatitis 1,197 867 1,307 1,804 4,679 9,854 Multi-drug resistant Pseudomonas aeruginosa ( MRPA) 4,433 5,292 - - - 9,725 Metacylin-resistant yellow staphylococcus ( MRSA) 3,376 3,920 - - - 7,296 syphilis 787 798 1,015 1,006 1,569 5,175 Acquired immunodeficiency syndrome 868 1,013 1,081 1,018 1,062 5,042 malaria 542 445 638 699 673 2,997 Hemorrhagic fever with nephrotic syndrome 364 527 344 384 575 2,194 Dengue fever 149 252 165 255 313 1,134 week) One) Influenza is a viral subtype ( H1N1, H1N1pdm09, H3N2) Number of analysis results 2)C The number of reports of hepatitis through sample monitoring 3)MRAB MRPA, MRSA In the case of, it is based on the number of reports through sample monitoring. 2013 Statistical data with the pathogen separation rate since Collected and excluded from this analysis -19- ☐ In the case of some infectious diseases, deaths steadily occur, threatening the public's health ○ Every year the deaths from tuberculosis 2 More than a thousand ○ Vibrio sepsis, SFTS In the case of tsutsugamushi and pneumococcal, every year 10 Cases of fatality ※ The number of deaths is counted from group 1 infectious diseases to 4th infectious diseases in accordance with the law. < table 9> lately 5 year( '13~'17) Current status of deaths due to infectious diseases in Korea ( Unit: number of deaths) Infectious diseases 2013 2014 2015 2016 2017 Tuberculosis 2,230 2,305 2,209 2,186 Not collected Vibrio sepsis 31 40 13 12 24 Severe febrile thrombocytopenia syndrome ( SFTS) 17 16 21 19 54 Tsutsugamushi 23 13 11 13 18 Pneumococcal 0 6 34 18 67 Middle East Respiratory Syndrome Not measured Not measured 38 0 0 Hemorrhagic fever with nephrotic syndrome 7 3 7 3 0 Japanese encephalitis 3 4 2 3 2 Creutzfeldt-Jakob disease 4 3 0 6 5 Legionellosis 0 0 One 8 17 Note) Uncollected is the annual report on infectious disease monitoring by the Centers for Disease Control and Prevention 2017 At the time of publication, statistics were not counted, and if not measured, the number of deaths in the year was not c Source: Infectious Disease Monitoring Yearbook 2017, Ministry of Health and Welfare, Center for Disease Control and Prevention ☐ The periodic appearance of infectious diseases causes health threats and social confusion for the Korean people. ○ (`08 Avian influenza) Jeonbuk Gimje, etc. 11 try, 19 Initiate · group · phrase 33 Occurred on a dog farm 670 Pills in dog farmhouse 830 Ten thousand poultry was killed · Indirectly 6,300 It is reported that KRW 100 million in economic damage has occurred 3) ○ (`09 Swine flu) ` 09 year 5 month 2 After the first confirmed patient on the day ` 09 year 9 month 20 By days 15,160 Confirmation of confirmed patients, ` 10 year 6 Total by month 263 Death toll, economically domestic annual GDP of 0.4%~9.1% It is reported to have affected 4) ○ (`15 Year MERS) ` 15 year 5 month 20 Have experience in working in the Middle East 60 After the male was first identified as a MERS patient 7 By month 186 There are two patients 38 Death toll, economic damage 9 Trillion won estimate 5) ○ (`16 Avian influenza) 2016 year 11 month 16 First suspicion report was received at a farmhouse in Haenam, Jeollanam-do, ` 17 year One About by month 3,000 Ten thousand poultry were killed and the economic damage was about One Approaching trillion won 6) 3) Economic damage measurement of highly pathogenic avian influenza outbreak, Korea Rural Economic Research Institute, 2008 4) Economic Impact of the New Influenza Pandemic, Korea Economic Research Institute, 2009 5) Estimation of Economic Loss in MERS Incident, Korea Economic Research Institute, 2015 6) Spread of avian influenza and economic damage, Hyundai Economic Research Institute, 2016 -20- - In Korea 2003 Since 2016 Total up to year 6 Turn outbreak of avian influenza < table 10> `03 Avian influenza outbreaks and virus types in Korea Domestic occurrence time The number of livestock killed Virus type 2003 year 12 Mon ~ 2004 year 3 month 528 10,000 horses H5N1 2006 year 11 Mon ~ 2007 year 3 month 280 10,000 horses H5N1 2008 year 4 Mon ~ 2008 year 5 month 830 10,000 horses H5N1 2010 year 12 Mon ~ 2011 year 5 month 647 10,000 horses H5N1 2014 year One Mon ~ 2014 year 7 month 1,396 10,000 horses H5N8 2016 year 11 Mon ~ 2017 year One Monthly basis 3,054 10,000 horses H5N6 ○ ('19 Measles, which rarely occurred in Korea, has recently been introduced to Korea. '19 year One About monthly 30 People patient occurrence 7) ☐ Severe febrile thrombocytopenia syndrome among legal infectious diseases in Korea ( SFTS), Influenza has a high overall risk It is a disease with a high importance of response ○ 2018 In 2008, the Centers for Disease Control and Prevention presented legal measures for infectious disease management and conducted risk analysis in accordance with the evaluation criteria of domestic prevalence and public health impact for each disease. ○ Among them, influenza and SFTS Assessing the disease as the disease with the highest overall risk -SFTS The likelihood of a domestic epidemic is rated as moderate and the public health impact is high - Influenza is rated as high in both the possibility of a domestic epidemic and its public health impact. < table 11> Risk analysis result by legal infectious disease Risk analysis ( '18.7 Per month) year Classification Disease name Management goal Domestic fashion Public health time Total risk Possibility Influence Viral hemorrhagic fever ① One class end Quick response Very low usually lowness Ebola virus disease Viral hemorrhagic fever ② One class I Quick response Very low usually lowness Marburg fever Viral hemorrhagic fever ③ One class All Quick response Very low usually lowness Lhasa fever One class la Viral hemorrhagic fever ④ Quick response Very low usually lowness 7) Demand for continuing attention following the increase in measles patients inflow from overseas, press release from the Ministry of Health and Welfare, 2019 -21- Risk analysis ( '18.7 Per month) year Classification Disease name Management goal Domestic fashion Public health time Total risk Possibility Influence Crimean Congo bleeding fever Viral hemorrhagic fever ⑤ One class hemp Quick response Very low usually lowness Hemorrhagic fever in south america Viral hemorrhagic fever ⑥ One class bar Quick response Very low usually lowness Lift Valley Heat One class four pock Quick response lowness height middle One class Ah pest Quick response lowness height middle One class character Anthrax Quick response lowness lowness lowness One class car Botulinum toxin Quick response lowness lowness lowness One class Car Tularemia Quick response lowness lowness lowness One class Get New infectious disease syndrome Quick response obscurity obscurity obscurity Severe acute respiratory syndrome One class wave Quick response lowness lowness lowness (SARS) Middle East Respiratory Syndrome One class Ha Quick response usually height usually (MERS) Animal influenza One class roughness Quick response lowness height usually Human Infectious Disease- ① H5Nx Animal influenza One class roughness Quick response lowness height usually Human Infectious Disease- ② H7N9 One class you Swine flu Quick response height obscurity obscurity One class more diphtheria Quick response Very low middle lowness Other 2 class end Tuberculosis middle lowness middle ( Separate measures) 2 class I varicella Suppression of increase height lowness lowness 2 class All Measles Maintenance lowness lowness lowness 2 class la cholera Suppression of occurrence lowness lowness lowness 2 class hemp typhoid Suppression of occurrence usually usually usually 2 class bar paratyphoid fever Suppression of occurrence lowness lowness lowness 2 class four Bacterial nature Suppression of occurrence lowness lowness lowness Intestinal bleeding 2 class Ah Suppression of occurrence lowness usually lowness Escherichia coli infection 2 class character A Hepatitis Reduction in occurrence usually usually usually 2 class car whooping cough Suppression of occurrence usually lowness lowness 2 class Car Mumps Suppression of increase usually lowness lowness 2 class Get German measles Maintenance lowness lowness lowness 2 class wave Folio Eradication Very low usually lowness 2 class Ha Meningococcal infection Suppression of occurrence lowness middle middle b Haemophilus 2 class roughness Suppression of occurrence Very low lowness lowness influenza 2 class you Pneumococcal infection Suppression of increase usually usually usually 2 class more Leprosy Maintenance lowness lowness lowness 2 class Dirty scarlet fever Suppression of increase usually lowness lowness Bancomy Resistant Yellow 2 class what ( Separate measures) Staphylococcus ( VRSA) Infectious disease Intra-growth bacteria genus carbapenem 2 class Burr ( Separate measures) Fungal species ( CRE) Infectious disease -22- Risk analysis ( '18.7 Per month) year Classification Disease name Management goal Domestic fashion Public health time Total risk Possibility Influence 3 class end tetanus Maintain the eradication level lowness Very low lowness 3 class I B Hepatitis Suppression of occurrence lowness height usually 3 class All Japanese encephalitis Maintenance lowness usually lowness 3 class la C Hepatitis Fighting promotion lowness height usually 3 class hemp malaria Fighting promotion lowness usually lowness 3 class bar Legionellosis Suppression of occurrence middle lowness middle 3 class four Vibrio sepsis Suppression of occurrence lowness usually lowness 3 class Ah typhus Suppression of occurrence Very low Very low Very low 3 class character Rash Suppression of occurrence lowness Very low lowness 3 class car Tsutsugamushi Reduction in occurrence usually lowness usually 3 class Car Leptospirosis Suppression of occurrence lowness lowness lowness 3 class Get Brucellosis Suppression of occurrence lowness lowness lowness 3 class wave hydrophobia Suppression of occurrence Very low lowness lowness 3 class Ha Hemorrhagic fever with nephrotic syndrome Reduction in occurrence lowness lowness lowness 3 class roughness Acquired immunodeficiency syndrome ( AIDS) Reduction in occurrence lowness lowness lowness Creutzfeldt-Jakob disease 3 class you Suppression of occurrence lowness lowness lowness Transformation Creutzfeldt-Jakob disease 3 class more Yellow fever Quick response Very low usually lowness 3 class Dirty Dengue fever Quick response lowness lowness lowness 3 class what Queue column Suppression of occurrence lowness lowness lowness 3 class Burr West Nile Fever Quick response lowness lowness lowness 3 class book Lyme disease Suppression of occurrence lowness lowness lowness 3 class uh Tick-borne encephalitis Quick response Very low lowness lowness 3 class that Uviser Quick response lowness Very low lowness 3 class wife Chikunkuniya fever Quick response lowness lowness lowness Severe febrile platelet reduction 3 class Big Suppression of occurrence usually height height syndrome( SFTS) 3 class foundation Zika virus infection Quick response lowness usually lowness 4 class end influenza Suppression of increase height height height 4 class I syphilis Reduction in occurrence usually usually usually 4 class All Roundworm Maintenance Very low Very low Very low 4 class la Onchocerciasis Maintenance lowness Very low Very low 4 class hemp Pinworm disease Suppression of occurrence lowness lowness middle 4 class bar Hepatic flukes Reduction in occurrence lowness lowness lowness 4 class four Pulmonary flukes Suppression of occurrence Very low lowness lowness 4 class Ah Intestinal flukes Reduction in occurrence lowness lowness lowness 4 class character Hand, foot and mouth disease Suppression of occurrence usually lowness lowness 4 class car gonorrhea Reduction in occurrence usually lowness lowness 4 class Car Chlamydia infection Reduction in occurrence usually lowness lowness 4 class Get Softness Suppression of occurrence lowness lowness lowness 4 class wave Genital herpes simplex Reduction in occurrence usually lowness lowness 4 class Ha Cheomgyu condylom Reduction in occurrence usually lowness lowness Bancomycin inner growth bacterium 4 class roughness ( Separate measures) (VRE) Infectious disease Methicillin-resistant yellow grapes 4 class you ( Separate measures) Bacteria ( MRSA) Infectious disease 4 class more Multi-drug resistant Pseudomonas aeruginosa ( Separate measures) -23- Risk analysis ( '18.7 Per month) year Classification Disease name Management goal Domestic fashion Public health time Total risk Possibility Influence (MRPA) Infectious disease Multidrug resistant asinetobacter bar 4 class Dirty ( Separate measures) Umani bacteria ( MRAB) Infectious disease 4 class what Salmonella infection Suppression of occurrence usually usually usually 4 class what Enteritis Vibrio Infection Suppression of occurrence lowness usually lowness 4 class what Enterotoxin E.coli Infection Suppression of occurrence lowness usually lowness 4 class what Intestinal invasive Escherichia coli infection Suppression of occurrence lowness usually lowness 4 class what Enteropathogenic Escherichia coli infection Suppression of occurrence lowness usually lowness 4 class what Campylobacter infection Suppression of occurrence usually usually usually Clostridium 4 class what Suppression of occurrence usually usually usually Perpregence Infection 4 class what Staphylococcus aureus infection Suppression of occurrence lowness usually lowness 4 class what Bacillus cerius infection Suppression of occurrence lowness usually lowness Yersinia Entero 4 class what Suppression of occurrence lowness usually lowness Coltica infection Listeria monocyto 4 class what Suppression of occurrence lowness usually lowness Genes Infection group A brother 4 class what Suppression of occurrence usually usually usually Rotavirus infection 4 class what Astrovirus infection Suppression of occurrence lowness usually lowness 4 class what Intestinal adenovirus infection Suppression of occurrence lowness usually usually 4 class what Norovirus infection Suppression of occurrence usually usually usually 4 class what Sandpaper virus infection Suppression of occurrence lowness usually lowness 4 class what Dysentery amoeba infection Suppression of occurrence lowness lowness lowness 4 class what Ramble flagellum infection Suppression of occurrence lowness lowness lowness 4 class what Small follicle spore infection Suppression of occurrence lowness lowness lowness 4 class what Protozoan infection Suppression of occurrence lowness lowness lowness 4 class Burr Adenovirus Suppression of increase middle lowness middle 4 class Burr Human Voca Virus Suppression of increase middle lowness middle 4 class Burr Parainfluenza Suppression of increase middle lowness middle 4 class Burr Respiratory syncytial virus ( RSV) Suppression of increase middle lowness middle 4 class Burr Rhinovirus Suppression of increase middle lowness middle 4 class Burr Human metapneumovirus Suppression of increase middle lowness middle 4 class Burr Human coronavirus Suppression of increase middle lowness middle 4 class Burr Mycoplasma Suppression of increase middle lowness middle 4 class Burr Chlamydia pneumonia Suppression of increase middle lowness middle 4 class book Leishmann flagellar disease Quick response Very low lowness Very low 4 class book Babes fever Quick response Very low lowness lowness 4 class book African sleeping sickness Quick response Very low lowness lowness 4 class book Schistosomiasis Quick response Very low lowness lowness 4 class book Chagas disease Quick response Very low lowness Very low 4 class book Guangdong hematopoiesis Quick response Very low lowness Very low 4 class book Parasiticosis Quick response Very low lowness lowness 4 class book Onchocerciasis Quick response Very low lowness Very low 4 class book Epilepsy Quick response Very low Very low Very low 4 class book Toxoplasmosis Suppression of occurrence lowness lowness lowness 4 class book Medinachiasis Quick response Very low Very low Very low -24- Risk analysis ( '18.7 Per month) year Classification Disease name Management goal Domestic fashion Public health time Total risk Possibility Influence 4 class uh Enterovirus infection Suppression of occurrence usually usually usually 4 class that Human papillomavirus ( HPV) Infectious disease Vaccination - - - Source: Legal infectious disease management measures by disease, 2018, Centers for Disease Control and Prevention ☐ The Korean Society of Infectious Diseases and the Korea Centers for Disease Control and Prevention have evaluated the risk of infectious diseases that may be introduced from overseas. E Hepatitis and trichinosis are evaluated as having a high risk ○ 2018 Established a multidisciplinary expert research team for infectious diseases that are not included in domestic legal infectious diseases among overseas legal infectious diseases in 2015, and comprehensively evaluated the probability and severity of the disease. ○ E Hepatitis and trichinosis are highly likely to occur in Korea and are evaluated to have a high severity, so the overall risk is high. - etc, 19. Erlichia, 20. Elizabeth King Kia, 22. Far Eastern tick-borne encephalitis, 24. Psoriasis, 27. Heartland virus disease, 29. E Hepatitis, 35. This parametric recursion, 36. Lymphocytic choriomeningitis, 45. Nipa Virer S, 46. North Asian tick fever, 57. Rift Valley Heat ( Rift Valley Fever), 59. St louis encephalitis, 63. Tahi Me fever, 65. Tick-borne recurrence, 67. Trichinosis is also evaluated as having a moderate risk < table 12> Comprehensive assessment of the likelihood of occurrence and severity of overseas infectious diseases Disease name Possibility of occurrence Perjury Comprehensive evaluation One. African tick fever very low very low very low 2. Alqumra Heat very low moderate low 3. Anaplasmosis low low low 4. Argentine hemorrhagic fever very low moderate low 5. Bama forest virus infectious disease very low very low very low 6. Bertiella bottle very low very low very low 7. Blastomycosis ( Blastomycosis) very low very low very low 8. Hemorrhagic fever in Bolivia very low moderate low 9. Brazilian bleeding fever very low very low very low 10. Carion bottle very low low low 11. Central European tick-borne encephalitis very low very low very low 12. Coccidioids mycosis very low very low very low 13. Colorado tick fever very low very low very low 14. Infectious pus low very low low 15. vaccinia very low very low very low 16. Crimean Congo bleeding fever very low moderate low 17. Nematode very low low low 18. Eastern equine encephalitis very low very low very low 19. Erlichia low moderate moderate 20. Elizabeth King Kia low moderate moderate 21. Epiletrojun bottle very low low low 22. Far Eastern tick-borne encephalitis moderate moderate moderate 23. Foot and mouth disease very low very low very low 24. Angiochia low moderate moderate 25. farcy( Glanders) very low low low 26. Esophagus ( Gongylonemiasis) very low very low very low -25- Disease name Possibility of occurrence Perjury Comprehensive evaluation 27. Heartland virus disease low moderate moderate 28. Hendra virus infection very low very low very low 29. E Hepatitis High High High 30. Herpes B Virus infection very low moderate low 31. Histoplasmosis very low very low very low 32. Kiyasner Forest Disease very low low low 33. Lacrose encephalitis low very low low 34. Jumper ( Louping ill) very low very low very low 35. This parametric recursion High low moderate 36. Lymphocytic choriomeningitis moderate moderate moderate 37. Macracanthocytosis very low very low very low 38. Maya Royal ( Mayarofever) very low very low very low 39. Menangle virus disease very low very low very low 40. Milker nodules very low very low very low 41. Monkey pock very low moderate low 42. Murray Valley Encephalitis very low very low very low 43. Fluke dwarfism ( Nanophyetiasis) very low very low very low 44. Newcastle disease very low very low very low 45. Nipa virus very low very high moderate 46. North Asian tick fever low moderate moderate 47. Omsk hemorrhagic fever very low moderate low 48. Onchocerciasis very low low low 49. Orofuche fever very low very low very low 50. Pasturella low low low 51. Penile animal infection very low very low very low 52. Powasan very low very low very low 53. Parrot disease ( Psittacosis; Ornithosis) very low moderate low 54. Queensland tick gut typhus very low moderate low 55. Seo Gyo-yeol( Rate bite fever) low low low 56. Rickettsiadu low very low low 57. Lift valley row( Rift Valley Fever) moderate moderate moderate 58. Ross River virus fever very low very low very low 59. St. Louis encephalitis low moderate moderate 60. Sandfly fever very low very low very low 61. Sindbis virus low low low 62. Southern tick rash very low very low very low 63. Tahina fever moderate moderate moderate 64. Tick paralysis very low very low very low 65. Tick-borne recurrence moderate moderate moderate 66. Trench row ( Trench Fever) very low low low 67. Trichinosis High High High 68. Tropical pulmonary eosinophilia very low very low very low 69. Excellent throwing infection very low moderate low 70. Venezuelan encephalitis very low very low very low 71. Venezuelan hemorrhagic fever very low low low 72. Besselbronn column very low low low 73. Western equine encephalitis very low very low very low 74. Zoological diphtheria very low moderate low Source: New management guidelines for foreign infectious diseases that can be introduced into Korea, Korean Society of Infectious Diseases, Korea Centers for Disease Control and Prevention, 2018 -26- 2. Current Status of Domestic Infectious Disease R&D Investment ☐ ( Analysis method) NTIS DB Analysis by extracting tasks using keywords related to infectious diseases ○ lately 5 year( '13 Year~̀ 17 Year) Total infectious disease tasks performed 6,548 Analyze the dog - Compose keywords including general terms related to infectious diseases and Korean and English names of legal infectious diseases, other names or related words < table 13> Keywords used to extract tasks related to infectious diseases set division keyword Infection, transmission, common, antibiotic, antibacterial, resistant, bacteria, fungi, virus, bacteria, General terms and non-court Parasites, Escherichia coli, diarrhea, vaccine, pneumonia, flu, Helicobacter, Gram-negative bacteria, Gram-positive bacteria, Infectious disease name related Killing, necrotizing, mastitis, surveillance system, quarantine, food poisoning Mers, MERS, Middle East Respiratory Syndrome, cholera, typhus, bleeding, hepatitis, diphtheria, whooping cough, Tetanus, measles, epidemic, mumps, rubella, polio, encephalitis, chickenpox, shingles, malaria, tuberculosis, hansen, scarlet fever, meningitis, legionella, vibrio, sepsis, rash, tsutsugamushi, leptospira, brucella (burcella), anthrax, rabies , Influenza, acquired immunodeficiency syndrome, AIDS, Disease name keyword: court Syphilis, Creutzfeldt, plague, yellow fever, dengue, pox, botulinum, severe acute respiratory syndrome, Korean name of infectious disease and SARS, SARS, tularemia, Q fever, West Nile, Lyme disease, Uviser, Chikungunya, roundworm, flatworm, Major in English name Pinworm, fluke, hand, foot, foot, gonorrhea, chlamydia, dyslexia, herpes simplex, cheumgyucondylom, vancomycin, Extract word staphylococcus, staphylococcus, VRSA, VISA, VRE, Enterococci, enterococci, methicillin, MRSA, Pseudomonas aeruginosa, MRPA, Acineto, MRAB, Carbapenem, Salmonella, Campylobacter, Clostridium, Bacillus, Yersinia, Listeria, Amoeba, Flagella, Sporeworm, Mycoplasma, Babes, Sleeping Disease, Chagas, Cantonese Nematode, Archworm, Filamentous Worm, Insect, Medida, foot and mouth disease, Marek, Ozesky, Newcastle, Avian, SFTS, Severe fever Disease name keyword: court Cervical cancer, cervical cancer, HPV, Human Papilloma, HBV, HCV, AIDS, HIV, Mad cow disease Other names for infectious diseases Prion, Spongy, CJD, rabies, AI Related words ○ If the name and contents of the project are listed below, it is excluded from infectious disease related projects. - Tasks not related to infectious diseases (simple error) - Anticancer vaccine challenge - Antimicrobial hygiene products related challenges (e.g. antibacterial packaging, antibacterial construction materials, etc.). However, antibacterial medical devices, subsidiary materials, air filters, and hospital facilities are included. - Infectious diseases and pests related to plant/crop - Research on microorganisms other than for infectious diseases (e.g., E. coli research for protein production, virus research as a gene carrier, etc.) -27- ☐ National infectious disease related R&D Investment is on the rise every year ○ lately 5 Year(` 13~̀ 17) Infectious diseases R&D Total investment is 10,140 Annual average of KRW billion 13.8% Government gun R&D Investment growth rate (annual average 3.5% Increase) - National infectious disease related R&D Investment in the government R&D About the rate of increase 3.9 Ship level < table 14> lately 5 Year( '13~'17) Government total by year R&D And national infectious diseases R&D invest year 2013 2014 2015 2016 2017 Sum CAGR division Government gun R&D( won) 16.9 article 17.8 article 18.9 article 19.1 article 19.4 article 92.1 article 3.5% Infectious diseases R&D( KRW 100 million) 1,482 1,809 1,927 2,436 2,486 10,140 13.8% Source: 2017 National R&D project execution status, KISTEP, 2018 ☐ Ministry of Science and Technology, Ministry of Welfare, Ministry of Agriculture and Food, etc. 3 Intensive investment (about 86.0%, 8,717 Billion) ○ Ministry of Welfare (about 25.4%, 2,578 Billion) 內 The Centers for Disease Control and Prevention, an organization responsible for quarantine, 8.8%( about 894 Billion) charge (of the welfare department 34.7%) - Centers for Disease Control and Prevention R&D Investment '13 year 92 From billion won '17 year 365 Increase to billion won [ Drawing 6] Distribution of infectious disease R&D investment by department ( '13 - '17 year) -28- ☐ National infectious disease R&D Investing 10 Investment in major areas of focus R&D Half of the investment ○ lately 5 Year(' 13~'17) 10 Investment in major research areas is about 5,154 KRW 100 million (about 50.8%) Accounted for about half (annual average 20.7% Increments) ※ After the establishment of the promotion strategy, investment in ten major research areas was expanded, compared to those of non-teens. June about 1.26 Times (about 283 Billion Won) make a difference load ○ Unresolved infectious diseases that occur periodically (influenza, vaccination diseases/vaccines) or have a high burden of disease ( Investment is focused on chronic infections and vaccination diseases, multidrug resistance, tuberculosis) - Influenza ( 8.4%), Chronic infection ( 7.7%), Multidrug resistance ( 6.9%), Vaccination/Vaccine ( 6.6%), New species/cause unknown ( 5.8%), Tuberculosis( 5.4%) Net - 非 10 Major business: Ministry of Industry (bio industry core technology development, etc.), Ministry of Science and Technology (Science and engineering personal basic research support, etc.), Welfare Department (disease overcoming, biopharmaceutical, clinical research infrastructure, etc.) < table 15> 10 National Infectious Diseases by Major Area R&D invest Unit: KRW 100 million 10 Major areas of focus 2013 2014 2015 2016 2017 Sum importance One. New species and unknown cause 20 4 100 213 253 590 5.8% 2. weather change 38 51 86 110 147 432 4.3% 3. Acquisition common 44 40 39 92 79 294 2.9% 4. influenza 141 269 175 147 124 856 8.4% 5. Multidrug resistance 94 124 142 156 182 698 6.9% 6. Tuberculosis 87 110 122 117 117 552 5.4% 7. Chronic infection 98 154 198 156 170 776 7.7% 8. Disaster preparedness/management 4 8 12 81 146 250 2.5% 9. Vaccination disease/vaccine 119 132 100 156 160 667 6.6% 10. Bioterrorism 7 5 11 8 7 39 0.4% 10 Vs total 652 897 985 1,236 1,385 5,154 50.8% 非 10 Vs field 830 910 943 1,201 1,102 4,985 49.2% Sum 1,482 1,809 1,927 2,436 2,486 10,140 100.0% -29- [ Reference] Article 2 Proposed in the car promotion strategy 10 Major areas of focus and related diseases 10 versus Focus Research Field Disease Range Details of Diseases in Focused Research Fields Key Research Area MERS/SARS Acute respiratory syndrome, etc. Ebola MERS( Acute respiratory), One. New and High-risk hemorrhagic fever syndrome, foreign infectious diseases Ebola( High risk bleeding fever), foreign inflow Infectious disease of unknown cause (pathogens with no domestic cases), etc. New infectious diseases, etc. Infectious disease of unknown cause Japanese encephalitis, malaria, tsutsugamushi, yellow fever, dengue fever, West Nile 2. weather change Zika virus ( Zika virus), fever, tick-borne encephalitis, chikunguna fever, Infectious diseases SFTS Tsutsugamushi, dengue fever, etc. Moderate febrile thrombocytopenia group ( SFTS), Zika virus, etc. Typhus, rash, leptospirosis, ' Between animals and people Brucellosis, rabies, infectious spongiform encephalopathy ( TSE), 3. Acquisition common Infectious diseases that spread ' medium CJD/vCJD, Queue, Tick-borne disease ( Lyme Disease, Infectious diseases 10 Specify the bell Anaplasma, Erlichia, Fever erythema, Batonella Etc.), toxoplasmosis, E Hepatitis, etc. Seasonal influenza, new species Seasonal influenza, swine flu, bird 4. influenza Influenza, avian influenza Influenza included Etc VRSA, VISA, VRE, MRSA, MRPA, MRAB, CRE, MDR Pathogen, Antibiotic-resistant bacteria 5. Multidrug resistant bacteria NDM-1 Producing bacteria, ESBL Infectious disease caused by Producing bacteria, etc. Caused by Mycobacterium tuberculosis 6. Tuberculosis Including MDR-TB Diseases such as pulmonary tuberculosis and extrapulmonary tuberculosis AIDS (HIV), hepatitis( HBV/HCV), 7. Chronic infection HIV/AIDS, B Infection, C Hepatitis, Human papillomavirus ( HPV), Genital Herpes Simplex, disease HPV, Herpes Virus Etc Cheomgyu condylom, etc. Due to infectious diseases and livestock infectious diseases 8. Infectious disease disaster For disaster preparedness and disaster management caused by infectious diseases Social disaster ( ICT Use of technology, Prepare and manage Necessary research Infectious disease patient recognition system establishment) Diphtheria, whooping cough, tetanus, measles, mumps, The target of the national vaccination project 9. Vaccination rubella, polio, chickenpox, b Haemophilus felled 10 Dog diseases and Disease and vaccine Influenza, pneumococcal, etc., related to vaccines Vaccine-based technology Basic research (adjuvant, delivery system Etc) Infectious disease prevention method Anthrax ( anthrax), pest( plague), pock, 10. Bioterrorism “ Bioterrorism Designated Infectious Disease ” And Botulinum toxin ( botulism), Tularemia ( tularemia), “ High risk pathogen ” Uviser, paralysis, smallpox smallpox) Etc -30-
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