CDP-choline (citicoline) and cognition CDP-choline acts as a source of choline and cytidine and is a essential intermediate in the synthesis of phospholipids. As a pro-drug of choline, it in part helps to facilitate ACh synthesis. Cholinergic pro-drugs have been suggested as therapeutic strategies in brain injuries and neuropsychiatric disorders and citicoline exerts some of its effects through its action on the levels of certain neurotransmitters and on some intracellular signaling processes. It seems to impact catecholamine levels in the CNS and boost DA through effects on synthesis and release [1]. Augmentation of conventional antidepressants has been noted, where CDP- choline enhanced the effectiveness of SSRIs It has been suggested to be a pro-cognitive strategy in schizophrenia, possibly through cholinergic mechanisms involving the α7-nAChRs [2] where acutely, it improved processing speed, working memory, verbal learning, verbal memory, and executive function in low baseline performers [3]. In dementias and cognitive impairment, it shows beneficial effects [4,5,6] In addictions, it seems to have neuroprotective and neurorestorative effects [7] [1] https://doi.org/10.33588%2Frn.75S05.2022311 [2] https://doi.org/10.1016/j.neulet.2015.02.032 [3] https://doi.org/10.1016/j.pbb.2015.02.004 [4] https://doi.org/10.3390/nu15020386 [5] https://doi.org/10.14336/ad.2022.0913 [6] https://doi.org/10.1177/26331055231152496 [7] https://doi.org/10.1016/j.jpsychires.2021.09.006 1