Home / My courses / For English Medium Students / General Medicine / Pharmacology / Final lesson on Drugs regulating tissue metabolism / Training test "Drugs regulating tissue metabolism" Started on Пятница, 17 декабря 2021, 12:15 State Finished Completed on Пятница, 17 декабря 2021, 12:47 Time taken 31 mins 18 secs Marks 123.00/123.00 Grade 100.00 out of 100.00 Question 1 Complete Mark 1.00 out of 1.00 Question 2 Complete Mark 1.00 out of 1.00 A child has been diagnosed to be having vitamin D dependent rickets. The most appropriate vitamin D preparation for child is: Select one: Calcifediol Cholecalciferol Calciferol Calcitriol A patient began taking alendronate and was advised to take large amount of water and remain in the standing position for at least half an hour till she had the first meal of the day. These instructions were given to reduce the risk of: Select one: Erosive esophagitis Cholelithiasis Osteonecrosis. Constipation Question 3 Complete Mark 1.00 out of 1.00 Question 4 Complete Mark 1.00 out of 1.00 Question 5 Complete Mark 1.00 out of 1.00 All of these drugs can be used in the treatment of postmenopausal osteoporosis: Select one or more: Thyroxine Calcium Teriparatide Alendronic acid Antithyroid drugs are administered for the treatment of: Select one: Hypothyroid status Thyrotoxicosis Congenital myxedema Loss of sexual power Hypothyroid infantilism Benefits of radioactive iodine in the treatment of thyrotoxicosis: Select one or more: Is highly effective Absence of pain Has long half-life (5 days) Painful procedure Requires one injection Low expense Question 6 Complete Mark 1.00 out of 1.00 Question 7 Complete Mark 1.00 out of 1.00 Question 8 Complete Mark 1.00 out of 1.00 Biphosphonates act by: Select one: Increasing the osteoid formation Increasing the mineralization of osteoid Decreasing the osteoclast mediated resorption of bone Decreasing the parathyroid hormone secretion Biphosphonates are used in the following cases: Select one or more: Hypercalcemia of malignancy Paget’s disease Vitamin D excess Postmenopausal osteoporosis Bone resorption is enhanced by: Select one: PgD2 PgE2 PgF2 PgI2 Question 9 Complete Mark 1.00 out of 1.00 Question 10 Complete Mark 1.00 out of 1.00 Question 11 Complete Mark 1.00 out of 1.00 Calcitonin causes hypocalcemia by: Select one: Decreasing renal tubular reabsorption of calcium Decreasing absorption of phosphorus Inhibiting bone resorption Promoting osteolysis Choose correct statements about β-blockers: Select one or more: Inhibit the peripheral conversion of T to T Reduce the level of thyroid hormones a lot Can be useful only in diagnostic purposes Cause clinical improvement of hyperthyroid symptoms 4 3 Choose the correct way to treat hypothyroidism: Select one or more: The combination the levothyroxine plus liothyronine is effective also The doctor has no need to check the level of TSH and free thyroxine It takes 6–8 weeks to reach steady state concentration, thus dosage changes should be made slowly Food has no influence on absorption of thyroxine Thyroxine should be administered on an empty stomach Only the levothyroxine can be administered Question 12 Complete Mark 1.00 out of 1.00 Question 13 Complete Mark 1.00 out of 1.00 Choose the preparations of biphosphonates: Select one or more: Rizendronic acid Fusidic acid Alendronic acid Zolendronic acid Valproic acid Choose the symptoms of hyperthyroidism: Select one or more: Decreased heart rate, stroke volume, cardiac output Decreased appetite, decreased frequency of bowel movements Increased appetite, increased frequency of bowel movements Increased heart rate, stroke volume, cardiac output Increased peripheral vascular resistance Decreased peripheral vascular resistance Warm, moist skin Pale, cool, puffy skin, face and hands Question 14 Complete Mark 1.00 out of 1.00 Question 15 Complete Mark 1.00 out of 1.00 Choose the symptoms of hypothyroidism: Select one or more: Increased heart rate, stroke volume, cardiac output Warm, moist skin Increased peripheral vascular resistance Decreased peripheral vascular resistance Increased appetite, increased frequency of bowel movements Decreased appetite, decreased frequency of bowel movements Decreased heart rate, stroke volume, cardiac output Pale, cool, puffy skin, face and hands Choose the thyroid hormone drugs: Select one or more: Radioactive iodine Lyothyronine Sodium levothyroxine Thiamazole Question 16 Complete Mark 1.00 out of 1.00 Question 17 Complete Mark 1.00 out of 1.00 Question 18 Complete Mark 1.00 out of 1.00 Chronic use of which of the following medications is most likely to cause osteoporosis: Select one: Warfarin Lovastatin Propranolol Prednisolone Conversion of T to T is inhibited by: Select one or more: Propylthyouracil Amiodarone Thiamazole Propranolol 4 3 Drug is applied in case of decreased level of thyroid hormones: Select one: Thiamazole Levothyroxine sodium Propylthiouracil Teriparatide Radioactive iodine Question 19 Complete Mark 1.00 out of 1.00 Question 20 Complete Mark 1.00 out of 1.00 Question 21 Complete Mark 1.00 out of 1.00 Ergocalciferol is: Select one: Vitamin K Vitamin A Vitamin D Vitamin D 2 3 In comparison with thiamazole propylthiouracil: Select one: Blocks the iodine organification Do not block the uptake of iodide by the gland Inhibits the peripheral conversion of T to T 4 3 Prevention or treatment of osteoporosis in postmenopausal women may be achieved by: Select one or more: Multivitamins Biphosphonates Calcium and vitamin D supplementation Question 22 Complete Mark 1.00 out of 1.00 Question 23 Complete Mark 1.00 out of 1.00 Question 24 Complete Mark 1.00 out of 1.00 Properties of thiamazole: Select one or more: Can be applied in case of hyperthyroid status Has goitrogenic activity Inhibits the synthesis of thyroid hormones Can be administered in patients with hypothyroidism (goiter) Inhibits the synthesis of thyrotropin alfa Select the correct assertion about calcitonin: Select one: It increases the calcium concentration in the blood plasma Is applied in case of osteoporosis It increases the calcium absorption from intestine It increases a bone decalcination Is administered in patients with acute hypocalcemia Select the isotope of iodine is used for TREATMENT of thyrotoxicosis: Select one: I I I I 126 131 123 124 Question 25 Complete Mark 1.00 out of 1.00 Question 26 Complete Mark 1.00 out of 1.00 Question 27 Complete Mark 1.00 out of 1.00 Select the true statement about radioactive iodine: Select one: None of all above Has ability to induce genetic damage Has ability to induce neoplasia Has ability to induce leukemia T in comparison with T : Select one or more: Has longer half-life (7 days) Requires multiple daily doses Has shorter half-life Is more potent 3 4 The excessive secretion of parathyroid hormone may cause: Select one: Exophtalm («bulging eyes»), tachycardia, raised body temperature Hypoglycemia, raised body temperature Suppression of immune system Apyretic tetanus, cataract, psychosis Water retention, raised blood pressure, increase in glucose concentration Question 28 Complete Mark 1.00 out of 1.00 Question 29 Complete Mark 1.00 out of 1.00 Question 30 Complete Mark 1.00 out of 1.00 The mechanism of action of propylthiouracil: Select one or more: Block the uptake of iodide by the gland Inhibition of peripheral deiodination of T to T Block the iodine organification Direct destruction of thyroid gland 4 3 The production of active form of vitamin D is inhibited by: Select one: Fibroblast growth factor 23 High level of calcium High level of phosphorus Parathyroid hormone What is the net effect of parathyroid hormone (PTH) on the serum levels of calcium and phosphorus: Select one or more: Level of the phosphorus is decreased Level of the calcium is increased Level of the phosphorus is increased Level of the calcium is decreased Question 31 Complete Mark 1.00 out of 1.00 Question 32 Complete Mark 1.00 out of 1.00 Question 33 Complete Mark 1.00 out of 1.00 What is the net effect of the vitamin D on the serum levels of calcium and phosphorus: Select one or more: Level of the calcium is decreased Level of the calcium is increased Level of the phosphorus is increased Level of the phosphorus is decreased Which of the following is a serious adverse effect seen with zolendronate: Select one: Ventricular fibrillation Peptic ulcer Acute renal failure Anterior uveitis Which of the following statements about iodine is false? Select one: Inhibits the release of thyroxine Contraindicated in hyperthyroidism Inhibits the synthesis of iodo thyroxine and iodo thyronine Causes iodism Question 34 Complete Mark 1.00 out of 1.00 Question 35 Complete Mark 1.00 out of 1.00 Question 36 Complete Mark 1.00 out of 1.00 Which of these drugs is the fastest calcium lowering agent: Select one: Alendronate Calcitonin Rizendronate Zolendronate Choose the classification of octreotide: Select one: Synthetic analogue of thyrotropin-releasing hormone Growth hormone receptor antagonist Somatostatine synthetic analogue Gonadorelin synthetic analogue Choose the clinical application for oxytocin: Select one or more: Premature labor Suppress the vaginal bleeding in postpartum period Previous extensive uterine surgery Inducing of labor Question 37 Complete Mark 1.00 out of 1.00 Question 38 Complete Mark 1.00 out of 1.00 Question 39 Complete Mark 1.00 out of 1.00 Choose the correct assertions about tetracosactide: Select one or more: Is administered in case of Cushing’ syndrome Is synthetic analogue of corticotrophin Is applied in patients with secondary adrenal insufficiency Immunogenic activity is weak Choose the hormone which has both follicle stimulating hormone and luteinizing hormone in the ratio 1:1 in its structure: Select one: Lutropin alfa Urofollitropin Menotropins Pegvisomant Correct assertion about desmopressin are: Select one or more: It is a vasopressin derivate Can be administered in patients with diabetes type II Can be applied for labor induction It has diuretic activity Is used in case of diabetes insipidus Question 40 Complete Mark 1.00 out of 1.00 Question 41 Complete Mark 1.00 out of 1.00 Question 42 Complete Mark 1.00 out of 1.00 Define the growth hormone receptor antagonist: Select one: Danazol Pegvisomant Lanreotide Octreotide Define the influence of growth hormone on activity of cytochrome P450 isoforms: Select one: Has no influence Decreases the activity Increases the activity Define the name of recombinant form of growth hormone: Select one: Somatropin Tetracosactide Sermorelin Goserelin Question 43 Complete Mark 1.00 out of 1.00 Question 44 Complete Mark 1.00 out of 1.00 Question 45 Complete Mark 1.00 out of 1.00 Define the somastatine synthetic analogues: Select one or more: Lanreotide Danazol Octreotide Pegvisomant Define the synthetic analogues of gonadorelin: Select one or more: Gosereline Buserelin Urofollitropin Triptoreline Menotropin Posterior pituitary lobe hormone drugs and their synthetic analogues are: Select one or more: Urofollitropin Oxytocin Melatonin Goserelin Desmopressin Question 46 Complete Mark 1.00 out of 1.00 Question 47 Complete Mark 1.00 out of 1.00 Question 48 Complete Mark 1.00 out of 1.00 Select the follicle stimulating hormones: Select one or more: Follitropin alfa Urofollitropin Lutropin alfa Menotropins Select the indications of growth hormone: Select one or more: Diabetes type II Treatment of wasting in patient with AIDs Prader-Willi syndrome Acromegaly Turner syndrome Select the preparations with luteinizing activity: Select one or more: Choriogonadotropin alfa Menotropins Urofollitropin Follitropin alfa Lutropin alfa Question 49 Complete Mark 1.00 out of 1.00 Question 50 Complete Mark 1.00 out of 1.00 Select the usage of octreotide and lanreotide: Select one or more: Diarrhea — secretory, HIV-associated, chemotherapy induced Induction of ovulation Prader–Willi syndrome Hormone-secreting tumors: gastrinoma, insulinoma, VIPoma Acromegaly Tetracosactide is effective stimulator of secretion of: Select one or more: Androgenic steroids Thyroxine Glucocorticoids Insulin Norepinephrine Question 51 Complete Mark 1.00 out of 1.00 Question 52 Complete Mark 1.00 out of 1.00 Question 53 Complete Mark 1.00 out of 1.00 The following drugs are the hypothalamic hormones and their synthetic analogues: Select one or more: Thyrotropin Sermorelin Gonadorelin Octreotide Oxytocin Somatropin The main indication of bromocriptin is: Select one: Hyperprolactinemia Prostate cancer Central precocious puberty Endometriosis The main indication of pegvisomant: Select one: Acromegaly Diarrhea — secretory, HIV-associated, chemotherapy induced Prader–Willi syndrome Hormone-secreting tumors: gastrinoma, insulinoma, VIPoma Induction of ovulation Question 54 Complete Mark 1.00 out of 1.00 Question 55 Complete Mark 1.00 out of 1.00 Question 56 Complete Mark 1.00 out of 1.00 The nonpulsatile administration of gonadotropin-releasing hormone leads to: Select one or more: Stimulation of release of follicle-stimulating and luteinizing hormones Hypogonadotropic hypogonadism Inhibition the release of follicle-stimulating and luteinizing hormones in both women and men The pulsatile administration of gonadotropin-releasing hormone is responsible for: Select one: Stimulation of gonadotropins Inhibition the release of follicle-stimulating and luteinizing hormones Beclomethasone: Select one or more: Inhibition of the synthesis of endogenous glucocorticosteroids is significant Glucocorticosteroid for topical application Glucocorticosteroid for systemic use It is used for the treatment of bronchial asthma and vasomotor rhinitis Used in aerosol dosage forms