Otto Jespersen

PD-US

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This book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes.

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Iron–sulfur (FeS) centers are essential protein cofactors in all forms of life. They are involved in many key biological processes. In particular, Fe-S centers not only serve as enzyme cofactors in catalysis and electron transfer, they are also indispensable for the biosynthesis of complex metal-containing cofactors. Among these cofactors are the molybdenum (Moco) and tungsten (Wco) cofactors. Both Moco/Wco biosynthesis and Fe-S cluster assembly are highly conserved among all kingdoms of life. After formation, Fe-S clusters are transferred to carrier proteins, which insert them into recipient apo-proteins. Moco/Wco cofactors are composed of a tricyclic pterin compound, with the metal coordinated to its unique dithiolene group. Moco/Wco biosynthesis starts with an Fe-S cluster-dependent step involving radical/S-adenosylmethionine (SAM) chemistry. The current lack of knowledge of the connection of the assembly/biosynthesis of complex metal-containing cofactors is due to the sheer complexity of their synthesis with regard to both the (genetic) regulation and (chemical) metal center assembly. Studies on these metal-cofactors/cofactor-containing enzymes are important for understanding fundamental cellular processes. They will also provide a comprehensive view of the complex biosynthesis and the catalytic mechanism of metalloenzymes that underlie metal-related human diseases.

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The "SAP Certified Application Associate - SAP SuccessFactors Career Development Planning and Mentoring 1H/2023" certification exam verifies that the candidate possesses the basic knowledge in the area of the SAP SuccessFactors Career Development Planning application. This certificate proves that the candidate has a basic and overall understanding within this consultant profile of the industry solution, and can implement this knowledge practically in projects under guidance of an experienced consultant. It is recommended as an entry-level qualification to allow consultants to get acquainted with the fundamentals of SAP SuccessFactors Career Development Planning and Mentoring. This certification is intended for SAP partner consultants implementing the solution. Only registered SAP partner consultants will be provided with provisioning rights once they have been certified. Customers and independent consultants, even if certified, will not be provided with provisioning rights. There are no exceptions to this policy.

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ReduBurn

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The global public health community has focused care and funding on TB and HIV in Zambia, but adult policy-makers, doctors, and humanitarians often ignore children's perspectives as they confront infectious diseases. Well-intentioned practioners fail to realize how children take on active caregiving roles when their guardians become seriously ill. Using ethnographic methods, and listening to the voices of children as well as adults, Hunleth makes the caregiving work of children visible. Children actively seek to "get closer" to ill guardians by providing good care. Both children and ill adults define good care as children's attentiveness to adults' physical needs, their ability to carry out treatment and medication programs in the home, and above all, the need to maintain physical closeness and proximity.

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Conference papers from the Project Management Institute Australia Conference 2017, held on 29-30 May 2017 in Sydney, Australia.

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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Charles Sumner

PD-US

ANS

CC BY-NC-ND

"As the world has witnessed the worst financial crisis and climate crisis of our age, during the period of 2007-2009, the issues surrounding the emergence and development of financial markets and carbon markets is becoming an increasingly significant area of research and debate worldwide. By engaging with recently developed methods of research and new areas of practice, this book investigates the political, economic, policy and geographic determinants of the development of financial markets. The volume examines the causality between financial development and aggregate private investment from an economic perspective. It also explores the consequences of political liberalization, focusing on the impact of institutional improvement on financial development. It studies what stimulates governments to initiate reforms aimed at boosting financial development, and analyses the determinants of carbon markets in developing countries from a geographic point of view. This book is essential reading for all interested in economic and financial development, climate change, environmental economics, and applied econometrics. "

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In the last decades, historians and art historians have created an active historiographical debate about one of the most fascinating and studied iconographic themes of the Middle Ages: the royal divine coronation. Indeed, in the specific case of some Ottonian and Salian illuminations, it has been proposed that their function was not only political or to legitimize power, as traditionally suggested (Herrscherbilder), but also liturgical and religious (Memorialbilder). This has led to a complete rethinking of the meaning of this iconographic theme: the divine coronation of the king would not symbolically allude to his earthly power but to the wholly devotional hope of receiving the crown of eternal life in the afterlife. If this academic debate has been concentrated, above all, on Ottonian and Salian royal images, this Special Issue of Arts would like to deal with this topic by stimulating the analysis of royal divine coronation and blessing scenes in religious and liturgical context (mosaics, frescos, or paintings placed in cathedrals or monastic churches and illuminations of liturgical texts) with a wider geographical and temporal setting; that is, the European and Mediterranean kingdoms in the period from the 12th to the 15th centuries.

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"The contributions to this volume investigate relations of cohesion and coherence as well as instantiations of discourse phenomena and their interaction with information structure in multilingual contexts. Some contributions concentrate on procedures to analyze cohesion and coherence from a corpus-linguistic perspective. Others have a particular focus on textual cohesion in parallel corpora that include both originals and translated texts. Additionally, the papers in the volume discuss the nature of cohesion and coherence with implications for human and machine translation.The contributors are experts on discourse phenomena and textuality who address these issues from an empirical perspective. The chapters in this volume are grounded in the latest research making this book useful to both experts of discourse studies and computational linguistics, as well as advanced students with an interest in these disciplines. We hope that this volume will serve as a catalyst to other researchers and will facilitate further advances in the development of cost-effective annotation procedures, the application of statistical techniques for the analysis of linguistic phenomena and the elaboration of new methods for data interpretation in multilingual corpus linguistics and machine translation."

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Bashundhara Housing

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Explore how a strong sense of community and thoughtfully designed lifestyle amenities create a truly connected neighborhood, exemplified by Bashundhara Housing. This article delves into shared identity, social interaction points, health & wellness facilities (like Bashundhara Sports City), educational institutions, and smart living practices that foster belonging and enhance quality of life. Discover how Bashundhara's infrastructure encourages connection, leading to increased trust, mental well-

J. M. (James Matthew) Barrie

PD-US

Soap2day

In Him (2025), a young man joins a powerful coach to train for greatness. He believes this is his big chance. But soon, he finds that the coach hides something dark. The lessons become strange. The athlete feels weak, afraid, and confused. Shadows follow him. The gym feels haunted by secrets. Slowly, he learns that his coach’s success is built on something evil. The truth shocks him. He must fight not only for his dream but for his life. The film’s mystery grows with every scene.

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This book covers the principles and practices of processes and technologies applied for the treatment of saline wastewater with discharge and reuse purpose, and those applied for its valorisation. Saline wastewater was considered to present electrical conductivities over 2 mS/cm, which is the limit for crop irrigation. Saline wastewater management is described with respect to: Basics about salinity characterisation and environmental impact Effects of salinity on the wastewater physical-chemical treatments Effects of salinity on biological treatment processes Valorisation of saline wastewater for energy and materials production Technologies for saline wastewater treatment and salt recovery Urban and industrial saline wastewater treatment Treatment and Valorisation of Saline Wastewater includes two case studies evaluating the treatment of the effluents from a fish cannery and from a WWTP with seawater intrusions in the collecting system. This book is intended as a text reference book for post-graduate, PhD students and researchers interested in the effects of salinity on the wastewater treatment and valorisation processes. It also serves as a reference text for professionals working in the industrial and urban wastewater sector that deal with saline wastewater.

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