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The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.

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Supply chains consist of all processes which are needed in order to supply customers with the required products. Traditionally, supply chain management decisions are based on the economic performance of the involved parties. But in recent years, other criteria, such as quality, flexibility or the environment, have become important as well. Especially carbon emissions are high on the political agenda because they are considered to be a major cause of the greenhouse gas effect. In this work it is shown how the performance of supply chains can be evaluated considering both economic and environmental criteria. In particular, the work deals with dual sourcing in the context of the newsvendor model. The impact of environmental regulations (emission taxes and emission trading) on the decisions of companies is analysed.

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O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) e a indisciplina são na atualidade assuntos que aparecem com forte incidência no cotidiano escolar. Algumas condutas apresentadas pelas crianças, neste contexto, são vistas como indicativos de tal transtorno e isso vem contribuindo para que crianças ainda muito pequenas sejam encaminhadas pelos educadores aos profissionais da saúde, por apresentarem na escola comportamentos considerados indisciplinados, agitados e impulsivos. A presente pesquisa tem como principal objetivo, discutir a relação entre indisciplina e o diagnóstico de TDAH, a partir da queixa do professor da educação infantil. Pretende ainda, analisar a postura dos educadores diante do processo de patologização no campo educacional, levando em conta a sociedade eugênica e disciplinar, que foi consolidada com o processo de higienização ocorrido no início do século XX, como também, construir uma reflexão crítica acerca das práticas sociais e educativas que ora se configuram, mediante a análise da educação contemporânea e do resgate histórico da escolarização no Brasil. A pesquisa se caracteriza como um estudo de caso qualitativo e as estratégias metodológicas empregadas para a coleta de dados incluíram a observação participante, entrevistas semiestruturadas, diário de campo e análise de documentos. Os resultados foram organizados em oito eixos temáticos e indicaram principalmente que os educadores apresentam dificuldades para estabelecer diferenças entre indisciplina e o TDAH e o que é normal e patológico, o que tem causado o aumento expressivo no número de encaminhamentos de crianças aos profissionais de saúde e a consequente patologização e medicalização da infância.

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