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to be completedDie „sexuelle Identität“ des Menschen ist keineswegs nur biologisch, sondern in erheblichem Maße auch neurologisch, psychologisch sowie durch Umweltbedingungen determiniert und infolgedessen gradualisiert. Die Gesellschaft und ihr Recht ignorieren diese Variabilitäten jenseits der natürlichen Geschlechtlichkeit jedoch mit Blick auf Orientierungsbedürfnisse weitgehend: Familien- und personenstandsrechtliche Zuschreibungen müssen eindeutig sein, Veränderungen des biologischen Geschlechts kommen nur in seltenen Ausnahmefällen in Betracht, die gesellschaftlichen Vorstellungen über den Freiraum an „sexueller Selbstbestimmung“ werden an den Grenzen strafrechtlich abgesichert und jene, die sich nicht daran halten, gelten in der Rechtspraxis entweder als schuldfähig oder haben mit u.U. langjährigem Freiheitsentzug im Rahmen der Sicherungsverwahrung zu rechnen. Dieses Spannungsfeld zwischen individueller Disposition und gesellschaftlicher Erwartung war Gegenstand eines Workshops, der am 20. November 2009 gemeinsam vom Institut für Humangenetik der Universitätsmedizin Göttingen und dem Zentrum für Medizinrecht der Juristischen Fakultät veranstaltet wurde. Der vorliegende Band enthält die Resultate eines interdisziplinären Dialogs von Experten/Innen aus der Humangenetik, der Sexualforschung, der Soziologie, des Medizinrechts und der forensischen Psychiatrie.
Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.
Beyond its identification with the second law of thermodynamics, entropy is a formidable tool for describing systems in their relationship with their environment. This book proposes to go through some of these situations where the formulation of entropy, and more precisely, the production of entropy in out-of-equilibrium processes, makes it possible to forge an approach to the behavior of very different systems. Whether for dimensioning structures; influencing parameter variability; or optimizing power, efficiency, or waste heat reduction, simulations based on entropy production offer a tool that is both compact and reliable. In the case of systems marked by complexity, it appears to be the only way. In that sense, realistic optimization can be carried out, integrating within the same framework both the system and all the constraints and boundary conditions that define it. Simulations based on entropy give the researcher a powerful analytical framework that crosses the disciplines of physics and links them together.
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Nanotechnologies leverage different hierarchical levels of novel technological applications by introducing molecular functionalities into the macroworld. A novel set of applications emerges by integrating photons and quantum information with the nanoworld. The current Special Issue “Dynamics and Applications of Photon Nanostructured Systems” is shaped by innovative ideas with strong, interdisciplinary, fundamental, theoretical, and applied characteristics, and the content covers a wide range of thematic areas in physics, chemistry and engineering. The book comprises twelve original studies and three review articles addressing novel nanodevices, functionalities, nanothermodynamics, chaos, non-linear dynamics, nanoresonators and applications based on photonic nanostructured devices and photon–nanomaterial interactions.
In this work two ideas of using individual metal organic molecules in applications for data storage are presented. On the one hand, metal-free phthalocyanine is used to form a GMR contact consisting of one single molecule leading to the world smallest magnetic sensor. On the other hand, chromium acetylacetonate was used to study the properties of magnetic molecules adsorbed on surfaces in order to build magnetic bits for date storage.
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Over the last few decades, remarkable progress has been made in understanding the aetiology and pathophysiology of diseases and many new theories emphasize the importance of the small bowel ‘ecosystem’ in the pathogenesis of acute and chronic illness. Emerging factors such as microbiome, stem cells, innate intestinal immunity and the enteric nervous system along with mucosal and endothelial barriers have key role in the development of gastrointestinal and extra-intestinal diseases. Therefore, the small intestine is considered key player in metabolic disease development, including diabetes mellitus, and other diet-related disorders such as celiac and non-celiac enteropathies. Another major field is drug metabolism and its interaction with microbiota. Moreover, the emergence of gut-brain, gut-liver and gut-blood barriers points toward the important role of small intestine in the pathogenesis of common disorders, such as liver disease, hypertension and neurodegenerative disease. However, the small bowel remains an organ that is difficult to fully access and assess and accurate diagnosis often poses a clinical challenge. Eventually, the therapeutic potential remains untapped. Therefore, it is due time to direct our interest towards the small intestine and unravel the interplay between small-bowel and other gastrointestinal (GI) and non-GI related maladies.
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Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging techniques which are widely used in nuclear medicine for the diagnosis and treatment follow-up of many major diseases. They use biomolecules as probes, which are labeled with radionuclides of short half-lives, synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. Their design and development require a rather interdisciplinary process involving many different disciplines of natural and health sciences. In addition to their diagnostic and therapeutic purposes in the field of nuclear medicine, radiopharmaceuticals provide powerful tools for in vivo pharmacology during the process of pre-clinical drug development to identify new drug targets, investigate the pathophysiology of diseases, discover potential drug candidates, and evaluate the pharmacokinetics and pharmacodynamics of drugs in vivo. Furthermore, they allow molecular imaging studies in various small-animal models of disease, including genetically engineered animals. The current collection of articles provides unique examples covering all major aspects in the field.
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