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Flowers have always played a powerful role in weddings, symbolizing love, purity, prosperity, and new beginnings. In Indian weddings, floral arrangements are not just decorative elements but sacred components deeply rooted in tradition and ritual.

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The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

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In this new Brookings Marshall Paper, Michael O’Hanlon argues that now is the time for Western nations to negotiate a new security architecture for neutral countries in eastern Europe to stabilize the region and reduce the risks of war with Russia. He believes NATO expansion has gone far enough. The core concept of this new security architecture would be one of permanent neutrality. The countries in question collectively make a broken-up arc, from Europe’s far north to its south: Finland and Sweden; Ukraine, Moldova, and Belarus; Georgia, Armenia, and Azerbaijan; and finally Cyprus plus Serbia, as well as possibly several other Balkan states. Discussion on the new framework should begin within NATO, followed by deliberation with the neutral countries themselves, and then formal negotiations with Russia.This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Backlist Books

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This book examines the current debate on nuclear non-proliferation and disarmament, notably the international non-proliferation regime and how to implement its disarmament provisions. Discussing the requirements of a new international consensus on nuclear disarmament and non-proliferation, this book builds on the three pillars of the nuclear non-proliferation treaty (NPT): non-proliferation, disarmament and peaceful uses of nuclear energy. It reviews the impact of Cold War and post-Cold War policies on current disarmament initiatives and analyses contemporary proliferation problems: how to deal with the states that never joined the NPT (India, Pakistan and Israel); how states that have been moving toward nuclear weapons have been brought back to non-nuclear-weapon status; and, in particular, how to deal with Iran and North Korea. The analysis centres on the relationship between disarmament and non-proliferation in an increasingly multi-centric world involving China and India as well as the US, the European powers and Russia. It concludes with a description and discussion of three different worlds without nuclear weapons and their implications for nuclear disarmament policies. This book will be of great interest to all students of arms control, strategic studies, war and conflict studies, and IR/security studies in general Sverre Lodgaard is a Senior Research Fellow at the Norwegian Institute of International Affairs, Oslo.Part 1: Power Shifts and Nuclear Weapons 1. Power Shifts and Nuclear Weapons Part 2: The Legacies of Nuclear History and the Requirements of a New Consensus on Non-proliferation and Disarmament 2. The First Nuclear Era 3. Post Cold War doctrines 4. A global consensus on non-proliferation and disarmament Part 3: Proliferation Problems and the Role of Nuclear Disarmament 5. The Three-State Problem 6. Rollback Experiences 7. The Case of Iran 8. How to Understand North Korea 9. The Relationship Between Disarmament and Non-Proliferation Part 4: Towards a Nuclear-Weapon-Free World 10. Towards a Nuclear-Weapon-Free World

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One of the most well-known ancient Chinese herbal formulas is Kedi Golden Six. It is the basis for many other Chinese medicines today and is commonly used to support Yin of the Yin-Yang principles. Yang is the mannish and positive principle in the Golden Six Capsule, whereas Yin is the womanly and negative principle. The foundation of good health is a strong Yin-Yang interplay and balance. Its benefits range from treating female infertility, effective against rheumatism, treating stroke, and helps eliminate menstrual pains.

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This exciting and original volume offers the first comprehensive critical study of the recent profusion of European films and television addressing sexual migration and seeking to capture the lives and experiences of LGBTIQ+ migrants and refugees. Queering the Migrant in Contemporary European Cinema argues that embodied cinematic representations of the queer migrant, even if at times highly ambivalent and contentious, constitute an urgent new repertoire of queer subjectivities and socialities that serve to undermine the patrolled borders of gender and sexuality, nationhood and citizenship, and refigure or queer fixed notions and universals of identity like ‘Europe’ and national belonging based on the model of the family. At stake ethically and politically is the elaboration of a ‘transborder’ consciousness and aesthetics that counters the homonationalist, xenophobic and homo/trans-phobic representation of the ‘migrant to Europe’ figure rooted in the toxic binaries of othering (the good vs bad migrant, host vs guest, indigenous vs foreigner). Bringing together 16 contributors working in different national film traditions and embracing multiple theoretical perspectives, this powerful and timely collection will be of major interest to both specialists and students in Film and Media Studies, Gender and Queer Studies, Migration/Mobility Studies, Cultural Studies, and Aesthetics.

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Particle-stabilized emulsions, today often referred to as Pickering/Ramsden emulsions, are vital in many fields, including personal care products, foods, pharmaceuticals, and oil recovery. The exploitation of these Pickering emulsions for the manufacture of new functional materials has also recently become the subject of intense investigation. While much progress has been made over the past decade, Pickering emulsion still remains a rich topic since many aspects of their behavior have yet to be investigated. The present “Pickering Emulsion and Derived Materials” Special Issue aims to bring together research and review papers pertaining to the recent developments in the design, fabrication, and application of Pickering emulsions. The themes include, but are not limited to:1. Interactions of colloidal particles confined at fluid interfaces2. Pickering emulsion-based polymerization3. Interfacial assembly and emulsion stabilization4. Rheology of particle laden interfaces and Pickering emulsions5. Functional materials templated from Pickering emulsions

Choosing the Best Accounting and Bookkeeping Services in USA is essential for ensuring financial accuracy, compliance, and long-term business growth. This guide explains how to evaluate providers based on industry experience, technology integration, pricing transparency, tax expertise, and communication standards. It also highlights the importance of compliance with regulations set by authorities like the Internal Revenue Service.

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The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies.