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Heterocycles feature widely in natural products, agrochemicals, pharmaceuticals and dyes, and their synthesis is of great interest to synthetic chemists in both academia and industry. The contributions of recent applications of new methodologies in C–H activation, photoredox chemistry, cross-coupling strategies, borrowing hydrogen catalysis, multicomponent and solvent-free reactions, regio- and stereoselective syntheses, as well as other new, attractive approaches for the construction of heterocyclic scaffolds are of great interest. This Special Issue is dedicated to featuring the latest research that is ongoing in the field of heterocyclic synthesis. It is expected that most submissions will focus on five- and six-membered oxygen and nitrogen-containing heterocycles, but structures incorporating other rings/heteroatoms will also be considered. Original research (communications, full papers and reviews) that discusses innovative methodologies for assembling heterocycles with potential application in materials, catalysis and medicine are therefore welcome.
يُعد يونيفورم أمن الشركات من أهم عناصر التنظيم والانضباط داخل أي مؤسسة أو منشأة، فهو ليس مجرد زي رسمي للعاملين، بل هو واجهة تُعبّر عن احتراف الشركة وحرصها على الأمان والنظام.
The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.
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Best known for his novels Tom Jones and Amelia, Henry Fielding was also an intrepid traveler and explorer who used his journeys around the world as fodder for his sprawling, picaresque works of fiction. Journal of a Voyage to Lisbon, Volume I collects Fielding's impressions of his trip to Portugal's capital. A must-read for fans of lively travel writing.
When installing or updating QuickBooks software, a common installation issue that arises is QuickBooks Error 1603. It usually signals a problem with one of the QuickBooks-required components, such as Microsoft XML Core Services or the Microsoft.NET Framework. This mistake may impede access to financial data and cause workflow to be disrupted. It can be fixed by trying a number of troubleshooting techniques, including upgrading Windows, fixing or reinstalling the.NET Framework, using the QuickBooks Install Diagnostic Tool, or contacting QuickBooks support. If you require prompt assistance and guidance, give the QuickBooks Support Team a call at 1-855-856-0042.
Due to the increasing demand for security and reliability in manufacturing and mechatronic systems, early detection and diagnosis of faults are key points to reduce economic losses caused by unscheduled maintenance and downtimes, to increase safety, to prevent the endangerment of human beings involved in the process operations and to improve reliability and availability of autonomous systems. The development of algorithms for health monitoring and fault and anomaly detection, capable of the early detection, isolation, or even prediction of technical component malfunctioning, is becoming more and more crucial in this context. This Special Issue is devoted to new research efforts and results concerning recent advances and challenges in the application of “Algorithms for Fault Detection and Diagnosis”, articulated over a wide range of sectors. The aim is to provide a collection of some of the current state-of-the-art algorithms within this context, together with new advanced theoretical solutions.
The central theme of this volume is the work of Sabahattin Ali, the Turkish author and translator from German into Turkish who achieved posthumous success with his novel Kürk Mantolu Madonna (The Madonna in the Fur Coat). Our contributors analyze this novel, which takes place largely in Germany, and several other texts by Ali in the context of world literature, (cultural) translation, and intertextuality. Their articles go far beyond the intercultural love affair that has typically dominated the discussion of Madonna. Other articles consider Zafer Şenocak’s essay collection Deutschsein and transcultural learning through picture books. An interview with Selim Özdoğan rounds out the issue.Im Mittelpunkt dieses Bandes steht das Werk des türkischen Autors und Übersetzers aus dem Deutschen Sabahattin Ali, der mit seinem Roman Kürk Mantolu Madonna (Die Madonna im Pelzmantel) zu posthumem Ruhm gelangte. Der Roman, der zum Großteil in Deutschland spielt, und andere seiner Werke werden unter Aspekten der Weltliteratur, (kultureller) Übersetzung und Intertextualität diskutiert. Damit reicht der Fokus weit über die bislang im Vordergrund stehende interkulturelle Liebesgeschichte in der Madonna hinaus. Weitere Beiträge beschäftigen sich mit Zafer Şenocaks Essaysammlung Deutschsein und dem transkulturellen Lernen mit Bilderbüchern. Ein Interview mit Selim Özdoğan rundet diese Ausgabe ab.
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