You want to read this book if you care about the news, how it is reported, how it is used, how it is misused, or what it means. You can use this book in a classroom on civics, journalism, or business. Or you can read this book as a confection... an enjoyableway of passing the time. Here is the surface plot (but, like the news, you'll have to read it, think about it, and do a little digging to find what is below the surface: More than 100 years ago Mr. Sherlock Holmes and Dr. John Watson learned the secret of eternal life. This explains how they were able to fight crimes and pursue justice for more than a century without seeming to age. By 1982 people had stopped caring about learning the truth. Without consulting clients, Holmes transformed himself into a hedge fund manager making rich people richer, and Dr. Watson became a speech writer for many of the world's most influential people. They assumed new identities and for three decades they lived separate lives as they became wealthy beyond measure. However, they began to age rapidly and in the fall of 2015 Holmes rented 221b Baker Street where he hoped to live out his final days. They reunited just as Holmes was about to apply the seven percent solution to his problems. But then a cryptic message arrived that sent the pair on their final adventure. Now their time is running out. In Calling All Irregulars they ask their trusty band of misfits to join the battle for truth and justice against the news media under the influence of the evil Professor Moriarty, who only cares about page views and profits. This book includes more than 45 puzzles that you can solve. Some are so easy that they will take only a few minutes and others might require dozens of people to collaborate for weeks or longer. Instructions are provided for how you can follow the progress of your fellow "Irregulars" as you become a consulting detective just like Sherlock Holmes.
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Protéger l'homme « au moment où il arrive au port de la vie », telle est la mission que les gouvernements français, de l'Ancien Régime à la IIIe République, assignent aux sages-femmes. Accompagnatrices des mères et désormais membres du corps médical, les sages-femmes se sont constituées au cours du XIXe siècle en profession scientifique, détentrice d'un savoir riche et varié. Partout en France, leur formation a occupé administrateurs et médecins, faisant naître des dizaines d'écoles dans les départements. This book is made open access as part of the Knowledge Unlatched OpenEdition Books Select 2018: HSS Backlist Books
The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology.
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Medien in ihrer historischen und technischen Vielfalt zu verstehen, das war das Versprechen, das Marshall McLuhan vor über fünfzig Jahren mit Understanding Media gegeben hatte. Unsere digital veränderte Gegenwart erfordert, das Buch heute erneut zu lesen und vor dem Hintergrund aktueller technischer Entwicklungen zu hinterfragen. Gegenstand des Sammelbandes sind u. a. McLuhans Idee von Medien als „Umwelten“, seine eigenwillige Sprache und Argumentation sowie seine Annahme der technischen Verfasstheit von Wahrnehmung.
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This monograph presents a view on grammaticalisation radically different from standard views centering around the cline of grammaticality. Grammar is seen as a complex sign system, and, as a consequence, grammatical change always comprises semantic change. What unites morphology, word order, constructional syntax and other grammatical subsystems is their paradigmatic organisation. The traditional concept of an inflexional paradigm is generalised as the structuring principle of grammar. Grammatical change involves paradigmatic restructuring, and in the process of grammatical change morphological, topological and constructional paradigms often connect to form complex paradigms. The book introduces the concept of connecting grammaticalisation to describe the formation, restructuring and dismantling of such complex paradigms. Drawing primarily on data from Germanic, Romance and Slavic languages, the book offers both a broad general discussion of theoretical issues and three case studies.
A literary landmark in its groundbreaking approach, as well as a priceless document of its age One of the most ambitious narratives of nineteenth-century realism, "Middlemarch" tells the story of an entire town in the years leading up to the Reform Bill of 1832, a time when modern methods were starting to challenge old orthodoxies. Eliot's sophisticated and acute characterization gives rich expression to every nuance of feeling, and vividly brings to life the town's inhabitants--including the young idealist Dorothea Brooke, the dry scholar Casaubon, the young, passionate reformist doctor Lydgate, the flighty young beauty Rosamond, and the old, secretive banker Bulstrode--as they move in counterpoint to each other. Art, religion, politics, society, science, human relationships in all their complexity--nothing is left unexamined under the narrator's microscope. Also included in this edition are pictures and an extensive section on George Eliot's life and works.
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