The volume provides the first systematic comparative approach to the history of forms of address in Portuguese and Spanish—two intimately related languages sharing historical, political and geographic contexts. Including theoretical reflections as well as fine-grained empirical studies, the volume relies on an innovative methodology, as it links traditional downstream diachrony with upstream diachronic reconstruction based on synchronic variation.
Photography is the art, application, and practice of creating durable images by recording light or other electromagnetic radiation, either electronically utilizing an image sensor or chemically employing a light-sensitive material such as photographic film.
John Brewer explores the essential nature of the social sciences and the ways in which notions of 'impact' and 'value' could be reframed to generate a more productive debate around their contribution to the good of society.
This PDF explores how homeowners can approach remodeling and renovation thoughtfully while respecting the historical integrity of their homes.
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In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.<false,>The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.<false,>This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.
Postharvest losses of fresh produce have always been an obstacle in agriculture. About one third of global fresh fruits and vegetables are lost because their quality has dropped below an acceptance limit. The postharvest quality and shelf life of fresh produce are also determined before harvest. However, postharvest quality is also affected by many practices during and after harvest such as temperature management, controlled and modified atmosphere, coatings, physical treatments, biocontrol, and more. This Special Issue on “Postharvest Disease Development: Pre and/or Postharvest Practices” gathers papers that deal with preharvest and postharvest factors that affect and maintain fresh produce quality after harvest.
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In Singapore, this journey begins with a thorough and multidisciplinary Cochlear Implant Singapore candidacy evaluation process.