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Dutch scholarship has played an important role in philology since the early days of Leiden University. This volume illuminates how philology and its focus on the critical examination of classical texts—a tradition that had previously exerted considerable influence across fields as diverse as theology, astronomy, law, and politics—began an accelerated process of specialization in the 1800s. As former subareas like linguistics and history branched off into independent fields with their own methodologies, philology found its authority narrowing in scope within newly defined boundaries. Providing a fresh perspective on the evolution of Dutch philology as a discipline in the humanities, this is a fascinating look at a historically vital field of thought.
This open access book explores how contemporary integration policies and practices are not just about migrants and minority groups becoming part of society but often also reflect deliberate attempts to undermine their inclusion or participation. This affects individual lives as well as social cohesion. The book highlights the variety of ways in which integration and disintegration are related to, and often depend on each other. By analysing how (dis)integration works within a wide range of legal and institutional settings, this book contributes to the literature on integration by considering (dis)integration as a highly stratified process. Through featuring a fertile combination of comparative policy analyses and ethnographic research based on original material from six European and two non-European countries, this book will be a great resource for students, academics and policy makers in migration and integration studies.
This book describes how man-made litter, primarily plastic, has spread into the remotest parts of the oceans and covers all aspects of this pollution problem from the impacts on wildlife and human health to socio-economic and political issues. Marine litter is a prime threat to marine wildlife, habitats and food webs worldwide.The book illustrates how advanced technologies from deep-sea research, microbiology and mathematic modelling as well as classic beach litter counts by volunteers contributed to the broad awareness of marine litter as a problem of global significance. The authors summarise more than five decades of marine litter research, which receives growing attention after the recent discovery of great oceanic garbage patches and the ubiquity of microscopic plastic particles in marine organisms and habitats.In 16 chapters, authors from all over the world have created a universal view on the diverse field of marine litter pollution, the biological impacts, dedicated research activities, and the various national and international legislative efforts to combat this environmental problem. They recommend future research directions necessary for a comprehensive understanding of this environmental issue and the development of efficient management strategies. This book addresses scientists, and it provides a solid knowledge base for policy makers, NGOs, and the broader public.
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"The definitive volume of this Late Classic site. . . . an important contribution to Oaxaca archaeology and to understanding Monte Alb at its peak and during its demise." Veronica Perez Rodriguez, American AnthropologistThis book is made open access as part of the Knowledge Unlatched KU Select 2016 Backlist Collection
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Polyphenols are plant non-nutrient natural products, or plant secondary metabolites, found in fruits, vegetables and seeds that we consume daily. Their intakes from fruit, vegetables, seeds, and nuts are associated with lower risks of chronic and age-related degenerative diseases. Aging is a dynamic and complex biological process involving multiple actors and subject to a number of genetic and/or environmental influences. The famous free radical theory of aging proposed by Prof. Harman in 1956 states that free radicals lead to oxidative damage, causing cellular dysfunction and physiological decline, and are responsible for aging, with the appearance of degenerative diseases and eventually death. From this hypothesis, antioxidant molecules are capable of slowing down the aging process through the successful scavenging of radical oxygen and nitrogen species. Polyphenols have been shown to prolong the lifespan of different model species operating through a well-conserved antioxidant mechanism. This collection of research and review articles covers the most recent advances in the use of plant polyphenols, ranging from their biological properties and possible functions as medicines, the importance of traditional medicines as a source of inspiration, the rationalization of new uses of plant extracts which lead to applications in modern medicine, the status of modern green-chemistry extraction methods, to some reflections on future prospects.
Aptamers are in vitro selected oligonucleotides capable of specific, high-affinity binding to a wide variety of target molecules. These features enable their application in diagnostics, therapeutics, targeted delivery, fluorescence imaging, and biosensing. Aptamers are isolated via the systematic evolution of ligands by exponential enrichment (SELEX), an iterative cycle of selection and amplification steps that enriches a randomly synthesised oligonucleotide library to a pool of specific, high-affinity aptamers. Since the inception of aptamers in 1990, the methods by which aptamers are selected have been improved, yielding a robust system capable of producing aptamers rapidly and at low cost. Recently, there has been an explosion in the field of aptamers including innovations in enhanced selection strategies, bioinformatics approaches, riboswitches, unnatural base pairs, nucleic acid nanostructures, and DNAzymes. This book combines excellent reviews with primary research articles to provide multidisciplinary perspectives on the frontiers of aptamer science in 2018.
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In der vorliegenden Arbeit wird versucht, eine möglichst erschöpfende Darstellung des Ideengehalts des LS ("Das Lied des Schicksals") zu geben und allen Verästelungen von Bloks esoterischer Mystik und anspielungsreicher Symbolik nachzugehen. Es zeigt sich, daß das LS zeitlich und thematisch einen besonders geeigneten Zugang zum Gesamtwerk Bloks ermöglicht.
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