Luis Henrique S. Zarif

John D. Hedengren

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Scheduling and control are typically viewed as separate applications because of historical factors such as limited computing resources. Now that algorithms and computing resources have advanced, there are new efforts to have short-term decisions (control) interact or merge with longer-term decisions (scheduling). A new generation of numerical optimization methods are evolving to capture additional benefits and unify the approach to manufacturing process automation. This special issue is a collection of some of the latest advancements in scheduling and control for both batch and continuous processes. It contains developments with multi-scale problem formulation, software for the new class of problems, and a survey of the strengths and weaknesses of successive levels of integration.

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The Reaper Protocol is a practical, no-BS guide for tree and landscape contractors who are spending money on Google Ads, LSAs, and SEO while watching their lead volume steadily decline. It breaks down why Google's local search ecosystem has turned into a pay-to-play trap, exposes why the agencies and gurus pushing it have a financial incentive to keep contractors inside it, and introduces a direct-response lead system that bypasses Google entirely by intercepting high-intent homeowners before th

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Voltaire

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Candide, ou l'Optimisme, (; French: [kɑ̃did]) is a French satire first published in 1759 by Voltaire, a philosopher of the Age of Enlightenment. The novella has been widely translated, with English versions titled Candide: or, All for the Best (1759); Candide: or, The Optimist (1762); and Candide: Optimism (1947). It begins with a young man, Candide, who is living a sheltered life in an Edenic paradise and being indoctrinated with Leibnizian optimism by his mentor, Professor Pangloss. The work describes the abrupt cessation of this lifestyle, followed by Candide's slow and painful disillusionment as he witnesses and experiences great hardships in the world. Voltaire concludes with Candide, if not rejecting Leibnizian optimism outright, advocating a deeply practical precept, "we must cultivate our garden", in lieu of the Leibnizian mantra of Pangloss, "all is for the best" in the "best of all possible worlds". Candide is characterized by its tone as well as by its erratic, fantastical, and fast-moving plot. A picaresque novel with a story similar to that of a more serious coming-of-age narrative (Bildungsroman), it parodies many adventure and romance clichés, the struggles of which are caricatured in a tone that is bitter and matter-of-fact. Still, the events discussed are often based on historical happenings, such as the Seven Years' War and the 1755 Lisbon earthquake. As philosophers of Voltaire's day contended with the problem of evil, so does Candide in this short novel, albeit more directly and humorously. Voltaire ridicules religion, theologians, governments, armies, philosophies, and philosophers. Through Candide, he assaults Leibniz and his optimism. As predicted by Voltaire Candide has enjoyed both great success and great scandal. Immediately after its secretive publication, the book was widely banned to the public because it contained religious blasphemy, political sedition, and intellectual hostility hidden under a thin veil of naïveté. However, with its sharp wit and insightful portrayal of the human condition, the novel has since inspired many later authors and artists to mimic and adapt it. Today, Candide is recognized as Voltaire's magnum opus and is often listed as part of the Western canon. It is among the most frequently taught works of French literature. The British poet and literary critic Martin Seymour-Smith listed Candide as one of the 100 most influential books ever written. From Wikipedia (CC BY-SA).

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Biohazard bags manufacturer

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In the past, ‘traditional’ moderate-intensity continuous training (60-75% peak heart rate) was the type of physical activity most frequently recommended for both athletes and clinical populations (cf. American College of Sports Medicine guidelines). However, growing evidence indicates that high-intensity interval training (80-100% peak heart rate) could actually be associated with larger cardiorespiratory fitness and metabolic function benefits and, thereby, physical performance gains for athletes. Similarly, recent data in obese and hypertensive individuals indicate that various mechanisms – further improvement in endothelial function, reductions in sympathetic neural activity, or in arterial stiffness – might be involved in the larger cardiovascular protective effects associated with training at high exercise intensities. Concerning hypoxic training, similar trends have been observed from ‘traditional’ prolonged altitude sojourns (‘Live High Train High’ or ‘Live High Train Low’), which result in increased hemoglobin mass and blood carrying capacity. Recent innovative ‘Live Low Train High’ methods (‘Resistance Training in Hypoxia’ or ‘Repeated Sprint Training in Hypoxia’) have resulted in peripheral adaptations, such as hypertrophy or delay in muscle fatigue. Other interventions inducing peripheral hypoxia, such as vascular occlusion during endurance/resistance training or remote ischemic preconditioning (i.e. succession of ischemia/reperfusion episodes), have been proposed as methods for improving subsequent exercise performance or altitude tolerance (e.g. reduced severity of acute-mountain sickness symptoms). Postulated mechanisms behind these metabolic, neuro-humoral, hemodynamics, and systemic adaptations include stimulation of nitric oxide synthase, increase in anti-oxidant enzymes, and down-regulation of pro-inflammatory cytokines, although the amount of evidence is not yet significant enough. Improved O2 delivery/utilization conferred by hypoxic training interventions might also be effective in preventing and treating cardiovascular diseases, as well as contributing to improve exercise tolerance and health status of patients. For example, in obese subjects, combining exercise with hypoxic exposure enhances the negative energy balance, which further reduces weight and improves cardio-metabolic health. In hypertensive patients, the larger lowering of blood pressure through the endothelial nitric oxide synthase pathway and the associated compensatory vasodilation is taken to reflect the superiority of exercising in hypoxia compared to normoxia. A hypoxic stimulus, in addition to exercise at high vs. moderate intensity, has the potential to further ameliorate various aspects of the vascular function, as observed in healthy populations. This may have clinical implications for the reduction of cardiovascular risks. Key open questions are therefore of interest for patients suffering from chronic vascular or cellular hypoxia (e.g. work-rest or ischemia/reperfusion intermittent pattern; exercise intensity; hypoxic severity and exposure duration; type of hypoxia (normobaric vs. hypobaric); health risks; magnitude and maintenance of the benefits). Outside any potential beneficial effects of exercising in O2-deprived environments, there may also be long-term adverse consequences of chronic intermittent severe hypoxia. Sleep apnea syndrome, for instance, leads to oxidative stress and the production of reactive oxygen species, and ultimately systemic inflammation. Postulated pathophysiological changes associated with intermittent hypoxic exposure include alteration in baroreflex activity, increase in pulmonary arterial pressure and hematocrit, changes in heart structure and function, and an alteration in endothelial-dependent vasodilation in cerebral and muscular arteries. There is a need to explore the combination of exercising in hypoxia and association of hypertension, developmental defects, neuro-pathological and neuro-cognitive deficits, enhanced susceptibility to oxidative injury, and possibly increased myocardial and cerebral infarction in individuals sensitive to hypoxic stress. The aim of this Research Topic is to shed more light on the transcriptional, vascular, hemodynamics, neuro-humoral, and systemic consequences of training at high intensities under various hypoxic conditions.

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This volume attempts to create a ‘relief map’ of temporalities in Estonian newspapers over different periods of time. The special focus is on binding the empirical analysis to the theoretical and methodological discussions of the temporality of news(paper) culture. The authors of the articles ask to what extent newspapers report on the past and present and to what extent these reports refer to the future. A diachronic analysis of newspaper texts from different periods of time demonstrates that the temporal focus of newspapers changes over time: in some periods, the past receives remarkably more attention, while in other periods the news timeframe is biased towards current events and the future. One study asks how similar, or different, is the (re)construction of the past in Estonian daily newspapers published in Estonian and Russian in 1994 and 2009. Two articles focus on analysis of the links between social remembering and anniversary journalism. Another article provides an overview of the depiction of women in Estonian newspapers and magazines from 1848 to 1940. This collection revitalizes the study of time in news discourse, suggesting new methodological perspectives and developing interdisciplinary approaches in cultural theory.

Rudolf Steiner

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