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Durch die systematische Ermittlung der fremdsprachigen Quellen der ersten bulgarischen Geographielehrbücher ist für die Analyse ihres Wortguts eine völlig neue Grundlage geschaffen worden, und es besteht Anlaß zu der Hoffnung, daß die hier zutagetretende Vielfalt der Kontaktmöglichkeiten auch die Diskussion über die Herausbildung und Entwicklung der bulgarischen Lexik des 19. Jahrhunderts als Ganzes voranbringt.

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Rechtlich gesetzte Grenzen sind Konstanten der zeitgenössischen politisch-rechtlichen Staatenrealität. Zugleich sind sie aber auch der (teilweise imaginierte) Ort, an dem das Versprechen auf steuerbare Migration umgesetzt werden soll: Neben den physischen sind es vor allem auch diese abstrakten Grenzen, die den Zuzug nach Europa bestimmen. Die disziplinübergreifenden Beiträge dieses Bandes untersuchen die Zugangsbedingungen für Menschen nach Europa und die damit zusammenhängende Relevanz von Recht und Grenzen. Neben philosophischen, juristischen, wirtschaftswissenschaftlichen und politologischen werden auch die journalistischen Beobachtungen des Lebens nach der Grenze sowie die filmische Auseinandersetzung mit dem Ankommen diskutiert. Dabei wird sowohl der theoretische Kontext als auch Kritik an bestehender Rechtspraxis konstruktiv ausgelotet.This book is made open access as part of the Knowledge Unlatched transcript OPEN library Politikwissenschaft

Charles S. (Charles Seymour) Robinson (editor)

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The efficacy of immunotherapeutic approaches in the treatment of different cancer types is becoming increasingly obvious, and immunotherapies in cancer treatment have experienced a significant breakthrough in the last few years. Immunotherapy encompasses several diverse treatment approaches, each of which has a distinct mechanism of action, and all of which are designed to boost or restore immune function in some manner. Consequently, T cell activating immunotherapeutic approaches like immune checkpoint inhibition, chimeric antigen receptor T cells (CARs), or bi-specific T cell activating antibodies are becoming increasingly important treatment strategies in different solid tumor types as well as in hematological malignancies. T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusions (DLI) due to the graft-versus-leukemia effect. In acute myeloid leukemia (AML) after intensive chemotherapy, most patients achieve complete remission; however, the overall survival for all AML patients, especially in elderly patients, is still relatively low. Immunotherapeutic approaches for AML patients might be options to reduce the relapse rate and improve overall survival. This Special Issue will focus on immunotherapeutic approaches in AML in established therapies, like the allogeneic stem cell transplantation including new concepts improving the graft-versus-leukemia effect, but also on new efforts to improve immune responses like adoptive T cell transfer, immune checkpoint inhibition, bi-specific antibodies, and CAR-T-cell approaches.

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William Playfair

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The History of the Decline and Fall of the Roman Empire is a six-volume work by the English historian Edward Gibbon. It traces Western civilization (as well as the Islamic and Mongolian conquests) from the height of the Roman Empire to the fall of Byzantium. Volume I was published in 1776 and went through six printings. Volumes II and III were published in 1781; volumes IV, V, and VI in 1788–1789. The original volumes were published in quarto sections, a common publishing practice of the time. The work covers the history, from 98 to 1590, of the Roman Empire, the history of early Christianity and then of the Roman State Church, and the history of Europe, and discusses the decline of the Roman Empire in the East and West. Because of its heavy use of primary sources, unusual at the time, its methodology became a model for later historians. This led to Gibbon's being called the first "modern historian of ancient Rome". His work remains a great literary achievement and a very readable introduction to the period, but considerable progress has since been made in history and archaeology, and his interpretations no longer represent current academic knowledge or thought. In The World of Late Antiquity (1971), Peter Brown offers an alternative interpretation of the period between the second and eighth centuries AD, and Framing the Early Middle Ages (2005) by Christopher Wickham presents hitherto unavailable evidence from both documentary and archaeological sources. From Wikipedia (CC BY-SA).

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Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.

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