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Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide, putting a major burden on life quality and social health care systems. Type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) have been identified as important risk factors for CVD, severely increasing the risk on e.g. myocardial infarction, and cardiovascular complications constitute the main cause of death in patients presenting with T2DM, CKD or a combination of both. As these pathologies are expected to rise alarmingly in the next decades, a better understanding of molecular and cellular mechanisms contributing to T2DM, CKD and CVD is required to improve prevention and treatment of these diseases. Furthermore, insight into the interplay between these pathologies and identification of molecular players interconnecting these comorbidities is of tremendous importance for optimal health management in the future. This Research Topic will focus on the chemokine receptor CXCR4 and its ligands CXCL12/SDF-1a and macrophage migration inhibitory factor (MIF) in the context of CVD and its link with T2DM and CKD, as well as address dipeptidyl peptidase-4 (DPP4) as an important protease destabilizing CXCL12. Chemokines and their receptors are important mediators of cell mobilization, recruitment and arrest, and also more broadly induce cell activation by triggering various intracellular signalling tracks. They control homeostatic conditions, but are also critically involved in inflammatory and pathological processes. Genome-wide association studies revealed single nucleotide polymorphisms connecting CXCL12 as well as MIF with CVD, and a role for both chemokines in T2DM and CKD has also been reported. In this review collection, current knowledge on molecular aspects of the CXCR4 ligand/receptor family and associated signalling pathways will be discussed. The physiological roles of CXCR4, CXCL12, MIF and DPP4 will be summarized, and recent findings on their function in pathological conditions of CVD, T2DM and CKD will be highlighted. This is combined with an extensive introduction providing insight into the pathologies of CVD, T2DM and CKD, discussing clinical features and common pathological aspects of these comorbidities on cellular and molecular level. Also, an overview of available animal models to study these diseases will be provided. This way, this Research Topic summarizes latest knowledge on this crucial molecular axis and its relationship with cardiovascular pathologies for both specialists and interested non-specialists and aims to stimulate further initiatives to unravel the mechanistic involvement of the CXCR4 ligand/receptor family in these morbidities, potentially paving the way for new therapeutical initiatives in the future.

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A trusted PDF list of PCD pharma companies for 2026 featuring Biostem Pharma, Curasia Medilabs, Orange Biotech, Bioversal Remedies, and Sunwin Healthcare, prepared using market insights and professional evaluation.

Bethany Stewart

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Mvv Builders

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Vital Health Chiropractic

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theronbethea

En los últimos años, la compra de medicamentos por internet se ha convertido en una alternativa cada vez más utilizada por personas que buscan comodidad, discreción y acceso a información detallada.

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This book focuses on central themes related to the conservation of bats. It details their response to land-use change and management practices, intensified urbanization and roost disturbance and loss. Increasing interactions between humans and bats as a result of hunting, disease relationships, occupation of human dwellings, and conflict over fruit crops are explored in depth. Finally, contributors highlight the roles that taxonomy, conservation networks and conservation psychology have to play in conserving this imperilled but vital taxon.With over 1300 species, bats are the second largest order of mammals, yet as the Anthropocene dawns, bat populations around the world are in decline. Greater understanding of the anthropogenic drivers of this decline and exploration of possible mitigation measures are urgently needed if we are to retain global bat diversity in the coming decades. This book brings together teams of international experts to provide a global review of current understanding and recommend directions for future research and mitigation.

Evangelos Vlachogiannis

A stock market advisory provider offers professional expertise on stocks and current market insight. Here are some benefits of hiring a stock market advisory service provider. For more details visit: https://www.ajmeraxchange.co.in/blogs/benefits-of-hiring-stock-market-advisory-service-provider

TENI PAUL - 212621382

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Why do some individuals choose to protest political grievances via non-violent means, while others take up arms? What role does whom we trust play in how we collectively act? This book explores these questions by delving into the relationship between interpersonal trust and the nature of the political movements that individuals choose to join. Utilizing the examples of the Arab Spring uprisings in Egypt, Libya and Syria, a novel theoretical model that links the literature on social capital and interpersonal trust to violent collective action is developed and extended. Beyond simply bringing together two lines of literature, this theoretical model can serve as a prism from which the decision to join terrorist organizations or violent movements may be analyzed. The implications of the theory are then examined more closely through an in-depth look at the behavior of members of political movements at the outset of the Arab Spring, as well as statistical tests of the relationship between interpersonal trust and terrorism in the Middle East and globally.This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Backlist Books

Kirloskar Generator

Every Dubai business operates differently, creating unique power generation demands. Standardized Kirloskar Generator solutions frequently miss operational nuances. MYSPAN recognizes that your facility's requirements demand customized engineering approaches. Our Kirloskar Generator expertise enables designing flexible power architectures matching your specific capacity demands, spatial constraints, noise tolerances, and expansion possibilities.

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Smartspace Architects

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The Women’s cricket calendar continues to gain momentum in 2026, and the upcoming clash between Gujarat Giants (GG) and UP Warriorz (UPW) on 22 January stands out as a highly anticipated contest. Fans are eager to see how both teams respond to pressure, form, and conditions. This preview by Reddy Anna Book offers a detailed, clear, and practical look at the match. Get Your ID Today - https://officialreddyannabook.com/

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HL Equipment

Avoiding these five mistakes—skipping inspection, ignoring torque and alignment, reusing old hardware, skipping calibration, and ignoring root causes—dramatically improves repair outcomes. Pair disciplined installation practices with quality Manitowoc parts from a reliable crane parts supplier, and the repair has its best chance to last.

Maximiani Julia Portas

I think it's time we blow this scene. Get everybody and the stuff together. OK, 3 2 1 Let's jam !

Teresa Yancy is an author, speaker, and coach. She has written books on personal development, leadership, and spirituality, including "The Messenger Life" and "Living on Purpose. Through her work, Yancy aims to inspire and empower others to create meaningful and fulfilling lives.