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South Florida’s Gold Coast doesn’t just keep up—it sets the pace. In 2026, the energy has shifted. The post-pandemic frenzy is gone, replaced by a more balanced market. But in Boca Raton, Fort Lauderdale, and Golden Beach, the ultra-luxury scene isn’t slowing down. Sales are breaking records, and the focus has turned to “legacy” properties—homes people want to keep in the family for generations.
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Acceptance or rejection of implanted biomaterials is strongly dependent on an appropriate bio-interface between the biomaterial and its surrounding tissue. Given the fact that most bulk materials only provide mechanical stability for the implant and may not interact with tissues and fluids in vivo, surface modification and engineering of biomaterials plays a significant role towards addressing major clinical unmet challenges. Increasing data showed that altering surface properties including physiochemical, topographical, and mechanical characteristics, is a promising approach to tackle these problems. Surface engineering of biomaterials could influence the subsequent tissue and cellular events such as protein adsorption, cellular recolonization, adhesion, proliferation, migration, and the inflammatory response. Moreover, it could be based on mimicking the complex cell structure and environment or hierarchical nature of the bone. In this case, the design of nano/micrometer patterns and morphologies with control over their properties has been receiving the attention of biomaterial scientists due to the promising results for the relevant biomedical applications. This Special Issue presents original research papers that report on the current state-of-the-art in surface engineering of biomaterials, particularly implants and biomedical devices.
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Nazar Mykhailovyn, the acting Chairman of the Board of the National Association of Sugar Producers of Ukraine Ukrtsukor, claims that Ukraine exported 265 thousand tons of sugar in just 7 months of the current marketing year (MY, September 2022 – August 2023), which is 4.8 times more than it did in the entire 2021–2022 marketing year.
Justice and Vulnerability in Europe contributes to the understanding of justice in Europe from both a theoretical and empirical perspective. It shows that Europe is falling short of its ideals and justice-related ambitions by repeatedly failing its most vulnerable populations.
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Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.
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This book, entitled “Mesoporous Metal Oxide Films”, contains an editorial and a collection of ten research articles covering fundamental studies and applications of different metal oxide films. Mesoporous materials have been widely investigated and applied in many technological applications owing to their outstanding structural and physical properties. In this book, important developments in this fast-moving field are presented from various research groups around the world. Different preparation methods and applications of these novel and interesting materials have been reported, and it was demonstrated that mesoporosity has a direct impact on the properties and potential applications of such materials. The potential use of mesoporous metal oxide films and coatings with different morphology and structures is demonstrated in many technological applications, particularly chemical and electrochemical sensors, supercapacitors, solar cells, photoelectrodes, bioceramics, photonic switches, and anticorrosion agents.
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