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The efficacy of immunotherapeutic approaches in the treatment of different cancer types is becoming increasingly obvious, and immunotherapies in cancer treatment have experienced a significant breakthrough in the last few years. Immunotherapy encompasses several diverse treatment approaches, each of which has a distinct mechanism of action, and all of which are designed to boost or restore immune function in some manner. Consequently, T cell activating immunotherapeutic approaches like immune checkpoint inhibition, chimeric antigen receptor T cells (CARs), or bi-specific T cell activating antibodies are becoming increasingly important treatment strategies in different solid tumor types as well as in hematological malignancies. T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusions (DLI) due to the graft-versus-leukemia effect. In acute myeloid leukemia (AML) after intensive chemotherapy, most patients achieve complete remission; however, the overall survival for all AML patients, especially in elderly patients, is still relatively low. Immunotherapeutic approaches for AML patients might be options to reduce the relapse rate and improve overall survival. This Special Issue will focus on immunotherapeutic approaches in AML in established therapies, like the allogeneic stem cell transplantation including new concepts improving the graft-versus-leukemia effect, but also on new efforts to improve immune responses like adoptive T cell transfer, immune checkpoint inhibition, bi-specific antibodies, and CAR-T-cell approaches.

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The History of the Decline and Fall of the Roman Empire is a six-volume work by the English historian Edward Gibbon. It traces Western civilization (as well as the Islamic and Mongolian conquests) from the height of the Roman Empire to the fall of Byzantium. Volume I was published in 1776 and went through six printings. Volumes II and III were published in 1781; volumes IV, V, and VI in 1788–1789. The original volumes were published in quarto sections, a common publishing practice of the time. The work covers the history, from 98 to 1590, of the Roman Empire, the history of early Christianity and then of the Roman State Church, and the history of Europe, and discusses the decline of the Roman Empire in the East and West. Because of its heavy use of primary sources, unusual at the time, its methodology became a model for later historians. This led to Gibbon's being called the first "modern historian of ancient Rome". His work remains a great literary achievement and a very readable introduction to the period, but considerable progress has since been made in history and archaeology, and his interpretations no longer represent current academic knowledge or thought. In The World of Late Antiquity (1971), Peter Brown offers an alternative interpretation of the period between the second and eighth centuries AD, and Framing the Early Middle Ages (2005) by Christopher Wickham presents hitherto unavailable evidence from both documentary and archaeological sources. From Wikipedia (CC BY-SA).

J. S. Adams, Mrs

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Robert Arnold

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Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.

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John Gardner (editor)

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This book contains manuscripts related to alloys (engineering materials) to discuss potential materials, methods for improvement of the strength and cyclic properties of alloys, the stability of microstructures, the possible application of new (or improved) alloys, and the use of treatment for alloy improvement. The broad spectrum of topics included in the articles of this Special Issue demonstrates that research into the microstructural and mechanical characteristics of alloys represents a contemporary field. These topics are also envisaged to be of interest to scientists in other research centers, and we can still expect new developments in this investigation field.

Mark Webor

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Not to be used for profit without explicit permission

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Poems relating chiefly to Klondike Gold Rush and to life in northern Canada.

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Menschen, die nicht eindeutig dem männlichen oder weiblichen Geschlecht zugeordnet werden können, sind gesellschaftlichen Stigmatisierungen und medizinisch-psychologischen Pathologisierungen ausgesetzt. Zentrale Studien im deutschsprachigen Raum bestätigen die Notwendigkeit eines fundamentalen Paradigmenwechsels im gesellschaftlichen Umgang mit Intergeschlechtlichkeit bzw. Intersexualität. Zwar hat die Auseinandersetzung mit dem Thema bereits Einzug in den Bildungsbereich erhalten, jedoch existieren bislang keine Veröffentlichungen zur professionellen Beratung von Inters*.Mithilfe der Analyse von Selbstdarstellungen und Expert_innen-Interviews werden im vorliegenden Buch konkrete Impulse und Handlungsempfehlungen für eine inter*-spezifische Beratungspraxis erarbeitet. Interdisziplinarität, Ressourcenorientierung und Personenzentriertheit werden als wichtige Grundpfeiler benannt, die es ermöglichen, neue methodische Denk- und Handlungsmuster zu formulieren. Dabei werden auch bisher bestehende Beratungsansätze und -konzepte aufgegriffen und unter Einbezug von Peers und Selbsthilfegruppen erweitert. So ergeben sich neue methodische Zugänge und Perspektiven, die sich an den Bedürfnissen und Wünschen intergeschlechtlicher Personen orientieren und ihnen Formen der Selbstermächtigung sowie barrierefreie Räume für selbstbestimmtes Agieren eröffnen.Intersex: Stimuli for CounselingPeople whose sex characteristics do not allow to identify them unambiguously as either male or female are exposed to social stigmatization as well as medical and psychological pathologization. Key studies conducted in the German-speaking countries acknowledge the need for a fundamental paradigm shift in the way society deals with intersex. But even though educators have already begun to consider the issue, there are still no publications about professional counseling of intersex people.Analyzing self-portraits and interviews with experts this book works out concrete recommendations and offers stimuli for a counseling practice catering to the specific needs of intersex people. Interdisciplinarity, an orientation to existing resources and a focus on the person are presented as the cornerstones that make it possible to formulate new methodological and action patterns, while existing counseling approaches are taken up and expanded with the involvement of peers and self-help groups. Thus, new perspectives for the self-empowerment of intersex people open, providing them with the barrier-free space necessary for self-determined action.

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Ziel dieser Arbeit soll die Analyse von Übersetzungsschwierigkeiten bei phraseologischen Einheiten aus dem Russischen ins Deutsche sein. Um einen theoretischen Rahmen und somit ein Begriffsinventar für diese Untersuchung zu erhalten, werden zunächst verschiedene übersetzungstheoretische Ansätze auf ihre Anwendbarkeit hin überprüft. Dem schließt sich ein Überblick über die wichtigsten Strömungen auf dem Gebiet der sowjetischen und deutschen Phraseologieforschung an.

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