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Neuropsychiatric diseases, such as schizophrenia, Alzheimer's disease, and etc., represent a serious medical and socioeconomic problems. These diseases are often accompanied by impairments of cognitive function, e.g., abstract thinking, decision-making, attention, and several types of memory. Such deficits significantly disrupt quality of life and daily functioning of patients. Cognitive deficits in neuropsychiatric diseases are associated with alterations of brain morphology and function, and are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, i.e. measurable phenotypes linking these disaeses with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Animal models may not mimic the full spectrum of clinical symptoms, but may act as analogies of particular behaviors or other pathological outcomes. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, several behavioral tests to measure cognitive performance in rodents and other species have been implemented. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of neuropsychiatric disorders, such as schizophrenia. This Research Topic also delineates future directions for translational studies aimed at developing novel treatments/interventions of cognitive disturbances.

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Mit dem vorliegenden Band wird die Herausgabe älterer slawischer Texte, die im Curriculum des Studiums der Slawischen Philologie eine Rolle spielen können, fortgesetzt (vgl. zuletzt die Nr. 3 der Materialien zum Curriculum der west - und südslawischen Linguistik, Band 25 dieser Reihe). Die Auswahl der Texte wurde anhand der Textzusammenstellung Reformacijsko slovstvo. Izbrano delo (eds. J. Pogačnik,...), Ljubljana 1976 getroffen. Mit einem Nachwort von Jože Pogačnik.

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In Murray Leinster's "Invasion," the unthinkable has come to pass -- a spacecraft has touched ground on American soil with intentions that seem to be nefarious. A lone U.S. soldier is trapped within the vast force field surrounding the ship, and he quickly determines that all is not as it appears to be. Will this intrepid warrior be able to communicate what he knows and thwart the invasion?

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<P>In der Reihe Marburger Abhandlungen zur Geschichte und Kultur Osteuropas erscheinen Monographien und Sammelbände aus dem Bereich der Slawistik. Neben literatur- und geschichtswissenschaftlichen Studien, die den thematischen Fokus der Reihe darstellen, finden auch Studien aus der Sprachwissenschaft Berücksichtigung.</P>

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Major depression is a severe and prevalent brain disorder with a high disability burden, hence the push for effective treatments. Antidepressants have been around since the 1950s, and although current medications are much more effective than early ones, there is still much room for improvement. "Real" antidepressants, defined as those that "repair" or "improve" the depression-causing mechanism in the brains of depressed patients, have yet to be identified. This book presents current research on depression and antidepressants, including use of antidepressants in alcohol use disorders and pregnancy, treatment-resistant depression, and development of potential new medications.

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Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.

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Le Volume 1 du RJCA comprend tous les arrêts, y compris les opinions individuelles ou dissidentes, les avis consultatifs, les décisions, ordonnances de procédure et les ordonnances portant mesures provisoires, rendus par la Cour entre 2009 et 2016. Pour chaque affaire, le Recueil comporte un bref résumé et des mots clés ainsi que les numéros des paragraphes correspondants, précisant le paragraphe exact de l’arrêt dans lequel la Cour a examiné les questions soulignées. Un index met en exergue les différents sujets traités dans ces affaires.« La Cour n’ayant pas produit de recueil de jurisprudence depuis sa création, la publication de ce premier volume marque une étape importante. Le Recueil sera un atout inestimable pour les chercheurs et praticiens du droit », affirme le Président de la Cour, l’Hon. Sylvain Oré. Il ajoute qu’en publiant ce Recueil, la Cour réduit considérablement les difficultés qui entravent l’accès à sa jurisprudence.

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ARC

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Philosophy in Australia and New Zealand has been experiencing something of a ‘golden age’. Within this, the richness of Australasia’s philosophical past, though less well known, should not be forgotten: Australasian philosophy includes much distinctive and highly original work. The Companion contains a wide range of articles by prominent philosophers and scholars, as well as important contributions by those outside academia. As well as longer essays on selected philosophers, philosophical topics and controversies, there are shorter entries on associations, research centres, departments, journals, pedagogy and international links. Philosophy’s recent inroads into the wider community are also highlighted. A Companion to Philosophy in Australia and New Zealand provides scholars and the wider community with a greater appreciation of the philosophical heritage of this region, and will be a standard work of reference for many years to come. “Judicious and authoritative” – Graham Priest

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