Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.
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"Empire and Catastrophe examines natural and anthropogenic disasters during the years of decolonization in Algeria, Morocco, and France, and explores the ways in which environmental catastrophes both shaped and were shaped by struggles over the dissolution of France’s empire in North Africa. Four disasters make up the core of the book: the 1954 earthquake in Algeria’s Chélif Valley, just weeks before the onset of the Algerian Revolution; a mass poisoning in Morocco in 1959 caused by toxic substances from an American military base; the 1959 Malpasset dam collapse in Fréjus, France, which devastated the Algerian immigrant community in the town but which was blamed on Algerian sabotage; and the 1960 earthquake in Agadir, Morocco, which set off a public relations war between the United States, France, and the Soviet Union, and which ignited a Moroccan national debate over modernity, identity, architecture, and urban planning. Empire and Catastrophe is the first book-length study of environmental disasters during the decolonization of the French empire. Interrogating distinctions between agent and environment and between political and environmental violence, through the lenses of state archives and through the remembered experiences and literary representations of disaster survivors, this book argues for the integration of environmental events into narratives of political and cultural decolonization. Empire and Catastrophe will be sought after by environmental historians and North Africa area studies specialists as well as historians of France and French imperialism. Written in engaging prose, the book will appeal to the broader public’s interest in natural disasters, and will become required reading for undergraduates in courses on natural disasters in world history."
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The growing world population exerts tremendous pressure on our finite food resources. Since the lion‘s share of the global calorie intake is reliant upon a handful of plant species like rice, wheat, maize, soybean, and potato, it is the need of the hour to expand our dietary reliance to nutritionally rich but neglected, underutilized, and yet-to-be-used wild plants. Such wild plants also have ethnomedicinal and biocultural significance. Owing to their ecosystem plasticity, they can be easily cultivated in diverse soil systems, including marginal, degraded, and other disturbed areas. Due to these resilient attributes, they can be considered for large-scale cultivation. However, proper biotechnological interventions are important for removing the negative traits as well as for standardizing the mass multiplication and cultivation strategies of such species for various agro-climatic regions. This Special Issue, “Wild Crop Relatives and Associated Biocultural and Traditional Agronomic Practices for Food and Nutritional Security”, was dedicated to showcasing the potential wild crop varieties of nutritional significance and associated biocultural knowledge from the diverse agroecological regions of the world and also to formulating suitable policy frameworks for food and nutritional security. The novel recommendations provided by this Special Issue can serve as a stepping-stone for utilizing wild and neglected crops as supplemental foods.
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