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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
In recent years, the industrial environment has been changing radically due to the introduction of concepts and technologies based on the fourth industrial revolution, also known as Industry 4.0. After the introduction of Industry 4.0 in large enterprises, SMEs have moved into the focus, as they are the backbone of many economies. Small organizations are increasingly proactive in improving their operational processes, which is a good starting point for introducing the new concepts of Industry 4.0. The readiness of SME-adapted Industry 4.0 concepts and the organizational capability of SMEs to meet this challenge exist only in some areas. This reveals the need for further research and action plans for preparing SMEs in a technical and organizational direction. Therefore, special research and investigations are needed for the implementation of Industry 4.0 technologies and concepts in SMEs. SMEs will only achieve Industry 4.0 by following SME-customized implementation strategies and approaches and realizing SME-adapted concepts and technological solutions. Thus, this Special Issue represents a collection of theoretical models as well as practical case studies related to the introduction of Industry 4.0 concepts in small- and medium-sized enterprises.
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