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The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.

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The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.

Bizde Kalmasin

Kitsa

Lumiere Children's Therapy is a full-service, multidisciplinary pediatric therapy practice located in Chicago.

ing. miguel soto

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Anjali Hanrao

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Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats.

Motmans Joz

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This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on “Metal Complex Interactions with Nucleic Acids and/or DNA”. This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the field of metal complex interactions with nucleic acids and/or DNA. Moreover, this Special Issue on "Metal Complexes Interactions with Nucleic Acids and/or DNA" provides an overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity.

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This volume investigates educational inequalities among children of Turkish immigrants in Austria, France, and Sweden. One of the largest immigrant groups in these countries, Turks nonetheless face discrimination and limited opportunities, and this study shows how those problems play out in education. One of its key findings is that systems that provide more favorable institutional arrangements lead to greater economic mobility in the second generation.

Momme von Sydow

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Although Charles Darwin predicted that his theory “would give zest to [...] metaphysics,” even he would be astonished at the variety of paths his theory has in fact taken. This holds with regard to both gene-Darwinism, a purified Darwinian approach biologizing the social sciences, and process- Darwinism found in the disciplines of psychology, philosophy of science, and economics. Although Darwinism is often linked to highly confirmed biological theories, some of its interpretations seem to profit from tautological claims as well, where scientific reputation cloaks ideological usage. This book discusses central tenets of Darwinism historically as well as systematically, for example the history of different Darwinian paradigms, the units-of-selection debate, and the philosophical problem of induction as basis of metaphysical Darwinism. Crucially the book addresses the Darwinian claim that evolution is governed by an immutable and unrelentingly cruel law of natural selection. Paradoxically, Darwin’s theory is a static, non-evolutionary theory of evolution. The current book sketches the historical background and provides suggestions that may help to replace this approach by the idea of an evolution of evolutionary mechanisms (see Escher’s “Drawing Hands” on the cover). This view even suggests a tendency to overcome the blindness of the knowledge acquisition of primordial Darwinian processes and allows for some freedom from external environments. This book first develops a radically Darwinian approach, then criticises this approach from within. Even Darwinism has a tendency to transcend itself. Although the book addresses several empirical issues, it does not challenge particular findings. Instead it builds on many insights of Darwinism and provides a proposal for interpreting known empirical evidence in a different light. It should help pave the way for further developing an understanding of nature that transcends Darwinian metaphysics.

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This open access book examines the educational conditions that support cultures of exploration in kindergartens. It conceptualises cultures of exploration, whether those cultures are created through children’s own engagement or are demanded of them through undertaking specific tasks within different institutional settings. It shows how the conditions for children’s exploration form a web of activities in different settings with social relationships, local landscapes and artefacts. The book builds on the understanding of cultural traditions as deeply implicated in the developmental processes, meaning that local considerations must be reflected in education for sustainable futures. Therefore the book examines and conceptualises exploration and cultural formation through locally situated cases and navigates toward global educational concepts. The book provides different windows into how children may explore in everyday practice settings in kindergarten, and contributes to a loci-based, ecological, integral knowledge relevant for early childhood education.

Akums Drugs and Pharmaceuticals Ltd

Association with a Nutraceutical Contract Manufacturing Can Improve Quality, Traceability, and Safety for Nutritional Manufacturers, Building Trust with Consumers.

dio apri

Kami SJP Rotan sebagai pengrajin sendiri di Malang jawa timur siap kirim keseluruh indonesia Memproduksi berbagai macam produk diantaranya : Sofa rotan sintetis, sofa bed kolam renang, floating tray, nampan apung , floating breakfast, floating breakfast pool, kursi kolam renang, sun lounger, kursi malas kolam renang, kursi teras, sofa malas, dll. Sebagai pengrajin juga jual dan harga yang kompetitif, Silahkan Kontak kami : No HP/Wa : 0857-5596-9664 Lokasi : Malang, Jawatimur www.sjprotan.com http://harga.sjprotan.com/

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Scholars have recently begun to study collections of Byzantine historical excerpts as autonomous pieces of literature. This book focuses on a series of minor collections that have received little or no scholarly attention, including the Epitome of the Seventh Century, the Excerpta Anonymi (tenth century), the Excerpta Salmasiana (eighth to eleventh centuries), and the Excerpta Planudea (thirteenth century). Three aspects of these texts are analysed in detail: their method of redaction, their literary structure, and their cultural and political function. Combining codicological, literary, and political analyses, this study contributes to a better understanding of the intertwining of knowledge and power, and suggests that these collections of historical excerpts should be seen as a Byzantine way of rewriting history.

Bethany Stewart

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Women in the Bible, Qumran and Early Rabbinic Literature: Their Status and Roles explores the different attitudes toward the woman

The Cottages Senior Living

Over six million people in the US live with Alzheimer's disease, the leading cause of mortality in the US. Over 11 million families offer care to their loved ones living with Alzheimer’s and other memory loss-related illnesses.

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Dependency is a fundamental concept in the analysis of linguistic systems. The many if-then statements offered in typology and grammar-writing imply a causally real notion of dependency that is central to the claim being made—usually with reference to widely varying timescales and types of processes. But despite the importance of the concept of dependency in our work, its nature is seldom defined or made explicit. This book brings together experts on language, representing descriptive linguistics, language typology, functional/cognitive linguistics, cognitive science, research on gesture and other semiotic systems, developmental psychology, psycholinguistics, and linguistic anthropology to address the following question: What kinds of dependencies exist among language-related systems, and how do we define and explain them in natural, causal terms?

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Interpreting the Labour Party consists of twelve essays on some of the principal thinkers and schools of thought concerned with the political and historical development of the Labour Party and the wider labour movement. It examines the major methodologies and approaches in Labour studies and critically evaluates much of the most interesting scholarship in this area of study. The essays are written by contributors who have devoted many years to the study of the Labour Party, the trade union movement and the various ideologies associated with them. The collection begins with chapters that examine Labour's ideological journey and assess the impact of the "new political history" on views of the party. Later contributions focus on how the problematic concept of "Labourism" has been applied to the party by the New Left and analyse how Labour's union link has been conceptualised. Key thinkers analysed include Henry Pelling, Ross McKibbin, Ralph Miliband, Lewis Minkin, David Marquand, Perry Anderson and Tom Nairn. Each chapter situates its subject matter in the context of a broader intellectual legacy, including the works of Sidney and Beatrice Webb, Theodore Rothstein, Stuart Hall and Samuel Beer, among others. The book will be of interest to undergraduate students of British politics and political theory, and to academics concerned with Labour politics and history, trade union history and politics, research methodology and political analysis.