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ATP is normally regarded as the major source of fuel for the energy-demanding processes within cells; however, ATP and other nucleotides (such as ADP, UTP, UDP) can be released from cells, where they act as autocrine or paracrine signaling molecules to affect cellular and tissue functions. In response to various stimuli, ATP and other nucleotides are released from cells in a regulated fashion, either by exocytosis of nucleotide-containing vesicles, or through channels in the plasma membrane. This process occurs in virtually every organ or cell in the body. The cellular effects of these extracellular nucleotides are mediated through specific membrane receptors (P2X and P2Y). These nucleotide signals can be terminated by rapid degradation of the ligand molecules by ecto-nucleotidases (e.g., NTPDases and NPPs). Many of the molecular components essential to nucleotide signaling have been cloned and characterized in detail, and their crystal structures are beginning to emerge. The collected data on extracellular nucleotides suggest a vivid and dynamic signaling system that is modulated by the expression and sensitivity of specific receptors on cells, and by the regulated release and extracellular degradation of ATP and other nucleotides; thus creating a microenvironment of highly regulated paracrine or autocrine control mechanisms. Within the kidney, extracellular nucleotides have emerged as potent modulators of glomerular, tubular, and microvascular functions. These functions include, but are not limited to, tubular transport of water and sodium, tubuloglomerular feedback and auto-regulation, regulation of blood pressure and the microcirculation, oxidative stress, and cell proliferation/ necrosis/apoptosis. Moreover, studies have also uncovered the interaction of nucleotide signaling with other mediators of renal function, such as vasopressin, aldosterone, nitric oxide, prostaglandins, angiotensin II, and the ATP-break down product adenosine. These insights have provided a more comprehensive and cohesive picture of the role of extracellular nucleotides in the regulation of renal function in health and disease. The availability of transgenic mouse models of the key proteins involved in nucleotide signaling has markedly enhanced our understanding of the physiological and pathophysiological roles of the different components of the system in the kidney. Although at a preliminary stage, the pathophysiological significance of this system in the kidney holds the key for the development of an entirely new class of drugs for the treatment of disease conditions, including disorders of water and/or sodium homeostasis, hypertension, acute kidney injury, etc. Thus, the regulation of renal function by extracellular nucleotides is clearly emerging as a distinct field and discipline in renal physiology and pathophysiology that has the potential to develop new drug treatments. In this e-book, we bring together a spectrum of excellent papers by leading experts in the field which present and discuss the latest developments and state-of-the-art technologies.Last but not least, we thank all the authors for contributing their valuable work and the Frontiers in Physiology Editorial Office for bringing out this e-book.

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Mobilising the concept of strategic culture, this study develops a sophisticated and innovative framework to understand developments in German security policy between 1990 and 2003. Germany's contemporary security policies are characterised by a peculiar mix of continuity and change. From abstention in the first Gulf war, to early peacekeeping missions in Bosnia in the early 1990s and a full combat role in Kosovo in 1999, the pace of change in German security policy since the end of the Cold War has been breathtaking. The extent of this change has recently, however, been questioned, as seen most vividly in Berlin's response to '9/11' and its subsequent stalwart opposition to the US-led war on terrorism in Iraq in 2003. Beginning with a consideration of the notion of strategic culture, the study refines and adapts the concept to the case of Germany through a consideration of aspects of the rearmament of West Germany. The study then critically evaluates the transformation of the role of the Bundeswehr up to and including the war on terrorism, together with Germany's troubled efforts to enact defence reforms as well as the complex politics surrounding the policy of conscription. By focusing on both the 'domestics' of security policy decision making as well as the changing and often contradictory expectations of Germany's allies, this book provides a comprehensive analysis of the role played by Germany's particular strategic culture in shaping policy choices. The book concludes by pointing to the vibrancy of Germany's strategic culture and argues that it will continue to define Berlin's approach to the use of force. Crucially, this may mean that Germany's perspectives may depart substantially from those of its key partners and allies. This book is essential reading for all those interested in contemporary European security as well as German politics.

Miguelito de Assis Medeiros

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A response is needed to the numerous issues spurred by the expansion of the gig economy, where flexible patterns of employment prevail in contrast to permanent jobs. In this context of the exponential growth of the digital economy and underlying business models the largest nationwide study of its kind into the impact of the working conditions in the UK music industry ‘Can Music Make You Sick?’ has been conducted by MusicTank/University of Westminster. This research suggests the need to consider the future of work not only from an economic or employment law perspective but from a mental health one too. What are the psychological implications of precarious work and how are factors such as financial instability, the feedback economy and personal relationships reflected in mental health outcomes or connected to the business relationships most musicians and other gig economy participants work under? Authors Sally-Anne Gross, George Musgrave and Laima Janciute consider which policy measures may help or harm gig economy workers including the taxation of self-employed workers, a universal basic income, education around mental health issues and access to mental health support.

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Players and Arenas brings together a diverse group of experts to examine the interactions between political protestors and the many strategic players they encounter, such as cultural institutions, religious organizations, and the mass media—as well as potential allies, competitors, recruits, and funders. Discussing protestors and players as they interact within the arenas of specific social contexts, the essays show that the main constraints on what protestors can accomplish come not from social and political structures, but from other players with different goals and interests. Through a careful treatment of these situations, this volume offers a new way to approach the role of social protest in national and international politics.

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