R. M. (Robert Michael) Ballantyne

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Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.

Frederick Douglass

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"Now," said he, "if you teach that nigger (speaking of myself) how to read, there would be no keeping him. It would forever unfit him to be a slave. He would at once become unmanageable, and of no value to his master. As to himself, it would do him no good, but a great deal of harm. It would make him discontented and unhappy." These words sank deep into my heart, stirred up sentiments within that lay slumbering, and called into existence an entirely new train of thought. It was a new and special revelation... -from Chapter VI It may be a measure of how far we have come, as a nation and as human beings, to feel shock to realize that one of the greatest Americans ever to have graced the cultural stage-editor, orator, author, statesman, and reformer FREDERICK DOUGLASS (1818-1895)-was born into bondage, merely by dint of the color of his skin. Taught to read and write by the wife of his owner, however, he escaped into an intellectual world that would become his extraordinary battleground for the freedom of those enslaved and, indeed, for the future of the United States. This work, first published in 1845, is the first of three autobiographies Douglass penned, and it became one of the most influential documents of a life in slavery ever written, as well as a powerful spur to the then-burgeoning abolitionist movement. From his childhood of abuse, neglect, and separation from family to his dramatic escape to the North, this is a stunning work of both literature and politics. An absolute classic not only of African-American history but of the history of the advance of human civilization, this is essential reading for anyone wishing to understand the turbulent story of the United States in the 19th century.

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This book showcases new research by emerging and established scholars on white workers and the white poor in Southern Africa. Rethinking White Societies in Southern Africa challenges the geographical and chronological limitations of existing scholarship by presenting case studies from Angola, Mozambique, South Africa, Zambia and Zimbabwe that track the fortunes of nonhegemonic whites during the era of white minority rule. Arguing against prevalent understandings of white society as uniformly wealthy or culturally homogeneous during this period, it demonstrates that social class remained a salient element throughout the twentieth century, how Southern Africa’s white societies were often divided and riven with tension and how the resulting social, political and economic complexities animated white minority regimes in the region. Addressing themes such as the class-based disruption of racial norms and practices, state surveillance and interventions – and their failures – towards nonhegemonic whites, and the opportunities and limitations of physical and social mobility, the book mounts a forceful argument for the regional consideration of white societies in this historical context. Centrally, it extends the path-breaking insights emanating from scholarship on racialized class identities from North America to the African context to argue that race and class cannot be considered independently in Southern Africa. This book will be of interest to scholars and students of southern African studies, African history, and the history of race.

Lasse, II, 41

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Durante séculos, diversos conhecimentos elaborados e mantidos por grupos sociais considerados à margem da sociedade receberam a classificação de conhecimento popular e conhecimento vulgar, o que demarcou o distanciamento entre esses saberes e o mundo das ciências. Este livro destaca, sob a perspectiva da etnobiologia, o potencial dos saberes tradicionais na construção de ações sustentáveis, refletindo sobre possíveis benefícios para a sociedade. Os autores oferecem análises e informações sobre a contribuição do conhecimento tradicional para a conservação da biodiversidade, para a segurança alimentar e para a saúde, por meio da utilização das plantas medicinais e de outras práticas nativas. O leitor vai perceber que, em muitos momentos, a imposição do mercado ou de pressões políticas não acarretou necessariamente uma melhoria real na alimentação ou na saúde da maior parte da população, como no exemplo dos problemas decorrentes de uma nutrição baseada em alimentos industrializados.

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Gewalt an Kindern kann sich in vielfältigen Formen physischer und psychischer Gewalt oder Vernachlässigung präsentieren. Die Kindstötung stellt den Kulminationspunkt der Gewalt oder das Resultat einer psychischen Störung der Täterin/des Täters dar. Mit erschreckender Regelmäßigkeit berichten die Medien über Kindstötungen. Die Fälle lösen nicht nur bundesweit Betroffenheit aus, sondern werfen auch Fragen nach Ursachen und effektiven präventiven Schutzmaßnahmen auf. Für Deutschland ist von 1–2 % Kindstötungen unter den Tötungsdelikten auszugehen. Aufgrund der Komplexität der dem Phänomen zugrunde liegenden Problematiken ist aber eine hohe Dunkelziffer anzunehmen, da sich auch hinter dem „Plötzlichen Kindstod“ Infantizide verbergen können und ein „Münchhausen-Syndrom by proxy“ mit dem akzidentellen oder sogar intendierten Kindstod enden kann. Das vorliegende Buch erfasst das Phänomen Kindstod und Kindstötung aus dem Blickwinkel von forensischen Psychiatern, Pädiatern, Rechtsmedizinern und Juristen. Ausgehend von historischen Betrachtungen zeigen die Experten anhand von Untersuchungen und Einzelfällen Spezifika auf, die von großer Bedeutung im medizinischen und juristischen Alltag sind und die in dieser aktuellen und umfassenden Form hiermit erstmals zusammengeführt werden.This book is made open access as part of the Knowledge Unlatched KU Open Services

Bradley Cleveland

John.J. Newman

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Edwin Waugh

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Experienced Commercial Cleaning es una solución esencial para empresas que buscan mantener sus instalaciones limpias, seguras y con una imagen profesional. Nova Neteja se especializa en este tipo de servicios, ofreciendo una limpieza comercial eficaz y adaptada a todo tipo de negocios, como oficinas, hoteles, tiendas y espacios corporativos. Su experiencia en el sector garantiza resultados de alta calidad en cada intervención. Al optar por Experienced Commercial Cleaning con Nova Neteja, los cli

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ATP is normally regarded as the major source of fuel for the energy-demanding processes within cells; however, ATP and other nucleotides (such as ADP, UTP, UDP) can be released from cells, where they act as autocrine or paracrine signaling molecules to affect cellular and tissue functions. In response to various stimuli, ATP and other nucleotides are released from cells in a regulated fashion, either by exocytosis of nucleotide-containing vesicles, or through channels in the plasma membrane. This process occurs in virtually every organ or cell in the body. The cellular effects of these extracellular nucleotides are mediated through specific membrane receptors (P2X and P2Y). These nucleotide signals can be terminated by rapid degradation of the ligand molecules by ecto-nucleotidases (e.g., NTPDases and NPPs). Many of the molecular components essential to nucleotide signaling have been cloned and characterized in detail, and their crystal structures are beginning to emerge. The collected data on extracellular nucleotides suggest a vivid and dynamic signaling system that is modulated by the expression and sensitivity of specific receptors on cells, and by the regulated release and extracellular degradation of ATP and other nucleotides; thus creating a microenvironment of highly regulated paracrine or autocrine control mechanisms. Within the kidney, extracellular nucleotides have emerged as potent modulators of glomerular, tubular, and microvascular functions. These functions include, but are not limited to, tubular transport of water and sodium, tubuloglomerular feedback and auto-regulation, regulation of blood pressure and the microcirculation, oxidative stress, and cell proliferation/ necrosis/apoptosis. Moreover, studies have also uncovered the interaction of nucleotide signaling with other mediators of renal function, such as vasopressin, aldosterone, nitric oxide, prostaglandins, angiotensin II, and the ATP-break down product adenosine. These insights have provided a more comprehensive and cohesive picture of the role of extracellular nucleotides in the regulation of renal function in health and disease. The availability of transgenic mouse models of the key proteins involved in nucleotide signaling has markedly enhanced our understanding of the physiological and pathophysiological roles of the different components of the system in the kidney. Although at a preliminary stage, the pathophysiological significance of this system in the kidney holds the key for the development of an entirely new class of drugs for the treatment of disease conditions, including disorders of water and/or sodium homeostasis, hypertension, acute kidney injury, etc. Thus, the regulation of renal function by extracellular nucleotides is clearly emerging as a distinct field and discipline in renal physiology and pathophysiology that has the potential to develop new drug treatments. In this e-book, we bring together a spectrum of excellent papers by leading experts in the field which present and discuss the latest developments and state-of-the-art technologies.Last but not least, we thank all the authors for contributing their valuable work and the Frontiers in Physiology Editorial Office for bringing out this e-book.

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