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The growth and health of our digital economies and societies depend on the core protocols and infrastructure of the Internet. This technical and logical substructure of our digital existence is now in need of protection against unwarranted interference in order to sustain the growth and the integrity of the global Internet. The Internet's key protocols and infrastructure can be considered a global public good that provides benefits to everyone in the world. Countering the growing state interference with this 'public core of the Internet' requires a new international agenda for Internet governance that departs from the notion of a global public good. Core ingredients of this strategy are:- To establish and disseminate an international norm stipulating that the Internet's public core - its main protocols and infrastructure- should be considered a neutral zone, safeguarded against unwarranted intervention by governments.- To advocate efforts to clearly differentiate at the national and international level between Internet security (security of the Internet infrastructure) and national security (security through the Internet).- To broaden the arena for cyber diplomacy to include new coalitions of states (including the so called 'swing states') and private companies, including the large Internet companies as well as Internet intermediaries such as Internet Service Providers.

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The rise of optogenetics as a standard technique to non-invasively probe and monitor biological function created an immense interest in the molecular function of photosensory proteins. These photoreceptors are usually protein/pigment complexes that translate light into biological information and have become essential tools in cell biology and neurobiology as their function is genetically encoded and can be conveniently delivered into a given cell. Like for fluorescent proteins that quickly became invaluable as genetically encodable reporters in microscopy and imaging, variants of photosensory proteins with customized sensitivity and functionality are nowadays in high demand. In this ebook we feature reviews and original research on molecular approaches from synthetic biology and molecular spectroscopy to computational molecular modelling that all aspire to elucidate the molecular prerequisites for the photosensory function of the given proteins. The principle property of changing activity of biological function simply by application of light is not only very attractive for cell biology, it also offers unique opportunities for molecular studies as excitation can be controlled with high time precision. Especially in spectroscopy the usually fully reversible photoactivation of photosensory proteins allows researchers to to perform time resolved studies with up to femtosecond resolution. In addition, functional variants can be investigated and quickly screened in common biochemical experiments. The insights that are obtained by the here presented various yet complementary methods will ultimately allow us write the script for a molecular movie from excitation of the protein by a photon to activation of its biological function. Such deep understanding does not only provide unique insights into the dynamics of protein function, it will also ultimately enable us to rationally design novel optogenetic tools to be used in cell biology and therapy.

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