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Die sprachliche und soziale Natur der Erkenntnis ist eine Grundeinsicht der Moderne. Doch welchen Spielraum lässt sie noch der Kritik, der distanzierten Prüfung der eigenen Sprache und Lebensform? Vor dem Hintergrund des Werkes Stanley Cavells fragt dieses Buch nach dem Verhältnis von Lebensform und Selbsterkenntnis. In ungewohnter Weise liest es Wittgenstein und Foucault als komplementäre Antwortstrategien auf dieses Grundproblem: Philosophie muss als eine »Arbeit an sich« (Wittgenstein), als körperliche »Selbsttechnik« (Foucault) verstanden werden. Nicht ethische Programmatik, so kann gezeigt werden, sondern systematische Konsequenz führt zu einer Engführung von Philosophie und Lebenspraxis.

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Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. However, some non-canonical caspase-1-independent proinflammatory cell death phenomena have been reported. Microbial pathogens are able to modulate host apoptosis and pyroptosis through different triggers and pathways. The promotion and inhibition of host apoptosis and pyroptosis vary and depend on the microbe types, virulence, and phenotypes. For example, virulent pathogens and attenuated vaccine strains may use different pathways to modulate host cell death. Specific microbial genes may be responsible for the modulation of host cell death. Different host cells, including macrophages, dendritic cells, and T cells, can undergo apoptosis and pyroptosis after microbial infections. The pathways of host apoptosis and pyroptosis induced by different microbes may also differ. Different methods can be used to study the interaction between microbes and host cell death system. The articles included in this E-book report the cutting edge findings in the areas of microbial modulation of host apoptosis, pyroptosis and inflammasome.

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Stanisław Ignacy Witkiewicz (1885-1939), genannt Witkacy, gehört zu den faszinierendsten Gestalten der europäischen historischen Avantgarde. Die im vorangehenden Zitat erwähnte Vielseitigkeit seiner Begabung erinnert an Künstler der Renaissance und der Aufklärung. In Anlehnung an die abstrakte Malerei entwickelte er nach dem 1. Weltkrieg die sog. Theorie der Reinen Form im Theater, mit der er sich gegen das naturalistische und symbolistische Drama wandte.

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Neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, anxiety disorders, and other mental disorders constitute about 13% of the global burden of disease surpassing both cardiovascular disease and cancer. The total cost worldwide of these diseases is estimated to exceed 100 million disability-adjusted life years. In order to begin to address this important problem, the present Research Topic brings together a group of leading affective neuroscience researchers to present their state-of-the-art findings using an affective neuroscience approach to investigate the spectrum of neuropsychiatric disorders from patients to those at risk. They focus on different aspects of the emotional and social cognitive disturbances which are core features of neuropsychiatric disorders. While progress has been slow over last couple of decades, we are finally beginning to glimpse some of the underlying neural mechanisms of the emotional and social cognitive disturbances in patients and those at risk. With the technological advances in affective neuroscience and neuroimaging presented in this volume, we hope that progress will be much swifter in the coming years such that we can provide better care for patients and those at risk.

Challenges Faced by AI Software Vendors [cerexio.com]

Smart Water Utilities How AI and IoT Are Reinventing Urban Water Management [Tigernix.com]

Industry 4.0 in Manufacturing [cerexio.com]

A Guide to Match Volunteers for Your Non-Profit Centre [Tigernix.com]

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Artificial intelligence techniques, such as expert systems, fuzzy logic, and artificial neural network techniques have become efficient tools in modeling and control applications. For example, there are several benefits in optimizing cost-effectiveness, because fuzzy logic is a methodology for the handling of inexact, imprecise, qualitative, fuzzy, and verbal information systematically and rigorously. A neuro-fuzzy controller generates or tunes the rules or membership functions of a fuzzy controller with an artificial neural network approach. There are new instantaneous power theories that may address several challenges in power quality. So, this book presents different applications of artificial intelligence techniques in advanced high-tech electronics, such as applications in power electronics, motor drives, renewable energy systems and smart grids.