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Although at first glance mechanisms used to create the variable domains of immunoglobulin appear to be designed to generate diversity at random, closer inspection reveals striking evolutionary constraints on the sequence and structure of these antigen receptors, suggesting that natural selection is operating to create a repertoire that anticipates or is biased towards recognition of specific antigenic properties. This Research Topics issue will be devoted to an examination of the evolution of antigen receptor sequence at the germline level, an evaluation of the repertoire in B cells from fish, pigs and human, an introduction into bioinformatics approaches to the evaluation and analysis of the repertoire as ascertained by high throughput sequencing, and a discussion of how study of the normal repertoire informs the construction or selection of in vitro antibodies for applied purposes.

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Discover the top 10 fireplace design ideas to elevate your living room with warmth, style, and elegance. From modern minimal fireplaces to classic statement designs, explore ideas that enhance comfort and visual appeal while complementing your interior décor perfectly. https://ekonty.com/blogs/504863/Top-10-Fireplace-Design-Ideas-to-Elevate-Your-Living-Room

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"looking at the available evidence, the use of slaves by antebellum railroads was one of the harshest forms of bondage endured by persons of African descent in the United States."

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Soldgeschäfte waren eine grundlegende Komponente schweizerischer und europäischer Geschichte der Frühen Neuzeit. Sie förderten einerseits den Klientelismus und provozierten andererseits Korruptionskritik. Die Autoren und Autorinnen untersuchen vor diesem Hintergrund die wirtschaftlichen und politischen Aktivitäten der 1799 ausgestorbenen Zuger Familie Zurlauben. Gleichzeitig veranschaulichen einzelne Beiträge zu Klientelismus, Patronage und Korruptionskritik und zu den länderübergreifenden Gewaltmärkten des 17. und 18. Jahrhunderts die europäischen Aspekte der Thematik in ihren unterschiedlichen ökonomischen, politischen und sozialen Dimensionen. Der vorliegende Band erscheint im Zusammenhang mit dem Abschluss der Edition der Acta Helvetica der Familie Zurlauben. This book is made open access as part of the Knowledge Unlatched KU Open Services

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When people move to a virtual private server, performance is usually the first reason. Stability often comes later—usually after the first unexpected outage or data scare. That’s when questions about uptime, redundancy, and backups suddenly feel very real.

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"A valuable account of how the Navajo involvement in railroad labor and underlying cultural values interface. It is the sensitivity to that cultural identity that gives the work a special edge and at the same time a broad appeal. It is extremely well written and well organized. Jay Youngdahl tells a good story while applying high standards of scholarship along with an underlying humanism." Paul Zolbrod, author/translator of Din Bahan: The Navajo Creation Story. For over one hundred years, Navajos have gone to work in significant numbers on Southwestern railroads. As they took on the arduous work of laying and anchoring tracks, they turned to traditional religion to anchor their lives. Jay Youngdahl has used oral history and archival research to write a cultural history of Navajos' work on the railroad and the roles their religious traditions play in their lives of hard labor away from home.

Colin McIntosh