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James Buchanan

PD-US

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The fifteen essays collected in Hard Reading argue that science fiction has its own internal rhetoric, relying on devices such as neologism, dialogism, semantic shifts, the use of unreliable narrators. It is a “high-information” genre which does not follow the Flaubertian ideal of le mot juste, “the right word”, preferring le mot imprévisible, “the unpredictable word”. Science fiction derives much of its energy from engagement with vital intellectual issues in the “soft sciences”, especially history, anthropology, the study of different cultures, with a strong bearing on politics. Both the rhetoric and the issues deserve to be taken much more seriously than they have been in academia, and in the wider world. Hard Reading is also a memoir of what it was like to be a committed fan, from teenage years, and also an academic struggling to find a place, at a time when a declared interest in science fiction and fantasy was the kiss of death for a career in the humanities.This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Backlist Books

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https://imagemagick.org

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This volume is made up of essays first presented as papers at the conference held in May 2015 at POLIN Museum of the History of Polish Jews in Warsaw. It is divided into two sections. The first deals with museological questions—the voices of the curators, comments on the POLIN museum exhibitions and projects, and discussions on Jewish museums and education. The second examines the current state of the historiography of the Jews on the Polish lands from the first Jewish settlement to the present day. Making use of the leading scholars in the field from Poland, Eastern and Western Europe, North America, and Israel, the volume provides a definitive overview of the history and culture of one of the most important communities in the long history of the Jewish people.This book is made open access as part of the Knowledge Unlatched KU Open Services

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Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a high growth potential, resistance to apoptosis, neoangiogenesis and metastasis, all essential parameters relevant for tumor progression. This makes FGFs, and their tyrosine kinase receptors FGFRs, valuable targets for therapeutic interventions. This book is a collection of 15 recent articles—both original work and reviews—that summarize the current research state effectively. The content covers FGF signaling aspects in gastric, skin, liver, esophageal cancer, melanoma, mesothelioma and glioblastoma, including one article that addresses the role of FGF in the tumor-microenvironment cross-talk. Several reports describe the development of compounds targeting FGFRs, their structure and interaction with the receptor molecules, and their effectivity in preclinical and clinical testing. In summary, the papers demonstrate the complexity of the topic, with various FGF ligands and receptors involved and the need for further research. They also present results that fuel hope that targeting cancer with dysfunctional FGF signaling can become a realistic treatment option.

Shmuly Zaklikofsky

https://imagemagick.org

Lisam Systems

Lisam Systems

Mr

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Akshay Dharmadhikari

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Dominic Goss

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