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Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease.
This volume presents the contributions to a symposium held on May 9th, 2009 at the Humanities Center at Harvard University that focused on the question of how peace and interstate stability were established and maintained in archaic and classical Greece. In this context, different perspectives and approaches, ranging from pragmatic political goals and the definition and interpretation of key terms such as eirene to the underlying norms and their relevance for the realpolitik, were discussed. The articles in this volume shed new light on the various political instruments that the Greeks developed and employed to avoid war and to keep and organize peace. They focus on the analysis of commonly accepted terms that provided the basis for a settlement between conflicting parties and the analysis of various political strategies, including one-time arrangements to limit military conflicts, diplomatic efforts, legally binding agreements and more comprehensive concepts of interstate stability.
Power outages can strike anytime—are you prepared? This comprehensive guide walks you through the key factors to consider when choosing a backup generator for your home. From sizing and fuel types to budget and safety, you’ll gain the confidence to pick the perfect model that keeps your household running smoothly.
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This conference volume unites a wide range of scholars from diverse fields in an effort to explore new perspectives and methods in the study of primary sources from the premodern world. It represents the culmination of the ERC's Synergy project Asia Beyond Boundaries, a research consortium of the British Museum, the British Library and the School of Oriental and African Studies, in partnership with Leiden University.
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From forgotten chores to mealtime madness, everyday life can be hectic—but not for long! This article showcases the budget-friendly gadgets smart American families are using to simplify routines, stay organized, and bring peace back to their homes. Practical, fun, and surprisingly affordable—these tools might just change your life.
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The Roots of the Mountains: Wherein is Told Somewhat of the Lives of the Men of Burgdale, Their Friends, Their Neighbors, Their Foemen, and Their Fellows in Arms is a fantasy romance by William Morris, perhaps the first modern fantasy writer to unite an imaginary world with an element of the supernatural, and thus the precursor of much of present-day fantasy literature. It was first published in hardcover by Reeves and Turner in 1889. Its importance in the history of fantasy literature was recognized by its republication by the Newcastle Publishing Company as the nineteenth volume of the Newcastle Forgotten Fantasy Library in April, 1979. According to Graham Seaman, "The Roots of the Mountains seems to be the story that inspired the subplot of the Dunedain, wanderers of a fading heroic past defending the frontiers of the Shire against the Orcs, and the loves of Aragorn, Eowyn, Faramir, and Arwen in Tolkien's Lord of the Rings." This work and its predecessor, The House of the Wolfings, are to some degree historical novels, with little or no magic. Morris went on to develop the new genre established in these works in such later fantasies as The Wood Beyond the World, Child Christopher and Goldilind the Fair, The Well at the World's End, The Water of the Wondrous Isles and The Sundering Flood. From Wikipedia (CC BY-SA).
The rate at which Nigerian youths are embracing the vice of homosexuality is alarming and the need for concerned authorities to sway into preventive measures at curbing this societal menace is of utmost importance. Prevention, they say, is better than cure. This was the submission of a socia crusader and President of One Love Foundation, Chief Patrick Eholor……..
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