In 2015, the first pharmaceutical cocrystal was approved by the FDA. Since then, the number of cocrystals on the market and in the development pipeline has been slowly but steadily growing. It is now well established that cocrystals are a versatile new approach to oral drug formulation. This Reprint Book is a collection of articles that show the utility of pharmaceutical cocrystals and various aspects of cocrystal research: • Cocrystals as a strategy to modify the physicochemical properties of a drug such as dissolution behaviour, tabletability, and melting point; • Development of new coformers; • Screening studies for multiple cocrystal forms; • Cocrystals in nano-sized drug delivery.
Neutrophils regulate immune responses during homeostasis as well as disease pathogenesis. Especially, the neutrophils extracellular traps largely contribute to necroinflammation. This book highlights the role of neutrophils and neutrophils extracellular traps in various sterile and non-sterile, acute and chronic inflammatory conditions affecting both human and animal health.
The Qur'an Seminar Commentary is an unprecedented work of collaboration in the field of Qur'anic Studies, involving the insights of 25 scholars on 50 Qur'anic passages. These scholars represent a diverse range of disciplinary backgrounds and provide readers with unique insights into the latest trends of research in the Qur'an. This Commentary is a useful and illuminating reference work for students and scholars in the field of Qur'anic Studies.This book is made open access as part of the Knowledge Unlatched KU Select 2016 Front List Collection
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Universalität der Menschenrechte oder einzelstaatliche Souveränität? Dieser Gegensatz entfaltet sich bei nahezu allen internationalen Konflikten. Vertreter beider Prinzipien setzen auf Gewalt als politisches Mittel. In einer Aktualisierung von Hannah Arendts politischer Philosophie zeigt Claas Christophersen, dass sich die fundamentalen Probleme menschlichen Zusammenlebens auf globaler Ebene nur dann lösen lassen, wenn sich die Weltgemeinschaft in Richtung einer transnationalen Demokratie weiterentwickelt und die politische Teilhabe aller Weltbürgerinnen und Weltbürger gewährleistet ist. Ein innovativer Beitrag zu einer der Schlüsselfragen transnationaler Politik.
The service covered by an obligation corresponds, in the definition offered by the law (art. 1174 of the Italian civil code), to an interest of the creditor. What happens if this interest, in the context of a contractual relationship, can no longer be satisfied due to unforeseen causes not attributable to the parties? The jurisprudence affirms that when an interest is objectively functional and necessary for the realization of the contractual program, its infringement can lead to the cancellation of the legal bond. However, what are the exact legal consequences of such cancellation, and what are its forms? This is the essential content of this work, aimed at investigating the foundation and content of the extra-legislative category of the unexpected unusability of a service.
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In this book, a new approach to the Industry 4.0 revolution is given. New policies and challenges appear and education in robotics also needs to be adapted to this new era. Together with new factory conceptualization, novel applications introduce new paradigms and new solutions to old problems. The factory opens its walls and outdoor applications are solved with new robot morphologies and new sensors that were unthinkable before Industry 4.0 era. This book presents nine chapters that propose a new outlook for an unstoppable revolution in industrial robotics, from drones to software robots
Through an examination of election campaign propaganda and various public relations campaigns, reflecting new electioneering techniques borrowed from the United States, this work explores how conservative political and economic groups sought to construct and sell a political meaning of the Social Market Economy and the Economic Miracle in West Germany during the 1950s.The political meaning of economics contributed to conservative electoral success, constructed a new belief in the free market economy within West German society, and provided legitimacy and political stability for the new Federal Republic of Germany.This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Backlist Books
Les Bienveillantes (The Kindly Ones), caused a literary sensation in 2006. Described as "deliberately repellent" by The New York Times, Jonathan Littell’s novel tells the story of World War II through the eyes of former SS officer Maximilien Aue. This is the first academic study of this controversial, best-selling work.Twenty-one leading scholars discuss the aesthetics, themes and characters of the novel, as well as formal aspects of Littell’s writing. They tackle ideas surrounding parricide, genocide, ant-Semitism and the Holocaust as well as Littell’s portrayal of both historical and fictional characters. The collection offers a deeply varied range of approaches to Littell’s work and is essential reading for anyone interested in representations of World War II, the Holocaust and contemporary French literature. All the essays in this collection are written in French.
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This edited book presents new results in the area of algorithm development for different types of scheduling problems. In eleven chapters, algorithms for single machine problems, flow-shop and job-shop scheduling problems (including their hybrid (flexible) variants), the resource-constrained project scheduling problem, scheduling problems in complex manufacturing systems and supply chains, and workflow scheduling problems are given. The chapters address such subjects as insertion heuristics for energy-efficient scheduling, the re-scheduling of train traffic in real time, control algorithms for short-term scheduling in manufacturing systems, bi-objective optimization of tortilla production, scheduling problems with uncertain (interval) processing times, workflow scheduling for digital signal processor (DSP) clusters, and many more.