Asem Talgatkyzy Yergalieva

Shaping the Future of Early-Onset Colorectal Cancer Prevention

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What controls the different rates of evolution to give rise to conserved and divergent proteins and RNAs? How many trials until evolution can adapt to physiological changes? Every organism has arisen through multiple molecular changes, and the mechanisms that are employed (mutagenesis, recombination, transposition) have been an issue left to the elegant discipline of evolutionary biology. But behind the theory are realities that we have yet to ascertain: How does an evolving cell accommodate its requirements for both conserving its essential functions, while also providing a selective advantage? In this volume, we focus on the evolution of the eukaryotic telomere, the ribo-nuclear protein complex at the end of a linear chromosome. The telomere is an example of a single chromosomal element that must function to maintain genomic stability. The telomeres of all species must provide a means to avoid the attrition from semi-conservative DNA replication and a means of telomere elongation (the telomere replication problem). For example, telomerase is the most well-studied mechanism to circumvent telomere attrition by adding the short repeats that constitutes most telomeres. The telomere must also guard against the multiple activities that can act on an unprotected double strand break requiring a window (or checkpoint) to compensate for telomere sequence loss as well as protection against non-specific processes (the telomere protection problem). This volume describes a range of methodologies including mechanistic studies, phylogenetic comparisons and data-based theoretical approaches to study telomere evolution over a broad spectrum of organisms that includes plants, animals and fungi. In telomeres that are elongated by telomerases, different components have widely different rates of evolution. Telomerases evolved from roots in archaebacteria including splicing factors and LTR-transposition. At the conserved level, the telomere is a rebel among double strand breaks (DSBs) and has altered the function of the highly conserved proteins of the ATM pathway into an elegant means of protecting the chromosome end and maintaining telomere size homeostasis through a competition of positive and negative factors. This homeostasis, coupled with highly conserved capping proteins, is sufficient for protection. However, far more proteins are present at the telomere to provide additional species-specific functions. Do these proteins provide insight into how the cell allows for rapid change without self-destruction?

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In recent years, the industrial environment has been changing radically due to the introduction of concepts and technologies based on the fourth industrial revolution, also known as Industry 4.0. After the introduction of Industry 4.0 in large enterprises, SMEs have moved into the focus, as they are the backbone of many economies. Small organizations are increasingly proactive in improving their operational processes, which is a good starting point for introducing the new concepts of Industry 4.0. The readiness of SME-adapted Industry 4.0 concepts and the organizational capability of SMEs to meet this challenge exist only in some areas. This reveals the need for further research and action plans for preparing SMEs in a technical and organizational direction. Therefore, special research and investigations are needed for the implementation of Industry 4.0 technologies and concepts in SMEs. SMEs will only achieve Industry 4.0 by following SME-customized implementation strategies and approaches and realizing SME-adapted concepts and technological solutions. Thus, this Special Issue represents a collection of theoretical models as well as practical case studies related to the introduction of Industry 4.0 concepts in small- and medium-sized enterprises.

Tirupati Balaji Package

Embark on a spiritual pilgrimage with our exclusive Tirupati Trip Package From Bangalore. Discover the divine allure of Tirumala as you journey from the bustling cityscape of Bangalore to the sacred hills of Tirupati. Immerse yourself in the rich cultural tapestry, ancient temples, and serene landscapes for an unforgettable and spiritually enriching experience.

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This book is devoted to the application of fractional calculus in economics to describe processes with memory and non-locality. Fractional calculus is a branch of mathematics that studies the properties of differential and integral operators that are characterized by real or complex orders. Fractional calculus methods are powerful tools for describing the processes and systems with memory and nonlocality. Recently, fractional integro-differential equations have been used to describe a wide class of economical processes with power law memory and spatial nonlocality. Generalizations of basic economic concepts and notions the economic processes with memory were proposed. New mathematical models with continuous time are proposed to describe economic dynamics with long memory. This book is a collection of articles reflecting the latest mathematical and conceptual developments in mathematical economics with memory and non-locality based on applications of fractional calculus.

DriveIT

ZDF

abdulmilik

Course Syllabus Fundamentals of Artificial Intelligence

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"Studies in the Middle East" is a one-year programme at the Near East School of Theology in Beirut (NEST). In honour of its 20th anniversary, academics and teachers from the NEST and from Germany met at Georg-August University in Göttingen and in the nearby Coptic Orthodox Monastery in Höxter-Brenkhausen to discuss the current situation in the Middle East and possible ways to initiate a spiritual new beginning in this crisis and war-ridden region. The present volume offers various contributions that were made on the subject.

A considered approach to kitchen design supports everyday routines, comfort, and visual balance throughout the home. At Inhaus Living, Kitchen Designers in Fyshwick focus on thoughtful layout planning, refined material selection, and attention to detail to ensure each kitchen connects naturally with surrounding spaces. Get in touch with Inhaus Living to discuss a kitchen design approach shaped around how you live and use your space.

I hope you like the method of The Ultimate Spreading eBook v2.1

Kim Hill

That's a fantastic bible precept, but it's a questionable management theory. It assumes that everyone is the same and that everyone will respond to the same treatment—being treated how you want to be treated. Many of your people, though, are not like you. Furthermore, they have nothing in common. You must also assist them in relating to one another by educating them to respect the other's style, strengths, and motivation.

Venture X Durham – RTP

Venture X Durham – RTP 600 Park Offices Dr Suite 300, Durham, NC 27709 (919) 529-5747

Mirnah Technology Systems

The world is witnessing a tremendous wave of tech-based enhancements and businesses aren’t nearly eager to fall behind in the race. Wondering what can be your enterprise’s biggest turning point? Well, here are some technologies to begin with.

ATUL GUPTA

Dhapoo Mewada

Global Ferrite Cores Market Research Report 2023 - Industry Analysis, Size, Share, Growth, Trends, and Forecast Till 2028 By DecisionDatabases.

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The purpose of this Special Issue is to create an an academic platform whereby high-quality research papers are published on the applications of innovative AI algorithms to transportation planning and operation. The authors present their original research articles related to the applications of AI or machine-learning techniques to transportation planning and operation. The topics of the articles encompass traffic surveillance, traffic safety, vehicle emission reduction, congestion management, traffic speed forecasting, and ride sharing strategy.

DELL

Period poverty can be defined as a lack of getting proper menstrual education, hygiene facilities, access to menstrual products, and waste management.

William de Wiveleslie Abney, Sir

PD-US

Competition Guru Chandigarh

Anuj Shinde

SS Singh

Turnkey Receptionist

One of the key benefits of using a virtual receptionist is cost savings. Traditional receptionists require a salary, benefits, and training, which can be expensive for businesses, especially small ones. Virtual receptionists, on the other hand, are a more cost-effective solution for telephone answering services in Sydney because they do not require the same level of human resources. Businesses can also save money on office space, as virtual receptionists do not need a physical location to work from.