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[This issue of Proceedings gathers papers presented at XOVETIC2018 (A Coruña, Spain, 27–28 September 2018), a conference with the main goal of bringing together young researchers working in big data, artificial intelligence, Internet of Things, HPC (high-performance computing), cybersecurity, bioinformatics, natural language processing, 5G, and others areas from the field of ICT(Information Communications Technology), and offering a platform to present the results of their research to a national audience in the north of Spain. This first edition aims to serve as the basis of this event, which will be consolidated over time and acquire international projection.The conference is co-funded by Xunta de Galicia and European Union. European Regional Development Fund (ERDF).]

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Using recent insights into the nature of early Christian communities as religious associations, this book offers a new reconstruction of the origins and development of the weekly Christian gathering and its constitutive elements; based on an analysis of all available evidence from the first three centuries.This book is made open access as part of the Knowledge Unlatched KU Select 2016 Backlist Collection

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Stephen Crane

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Maggie: A Girl of the Streets is an 1893 novel by American author Stephen Crane. Often called a novella because of its short length, it was Crane's first published fictional work. Because the work was considered too risqué by publishers, Crane, who was 21 years-old at the time, had to finance the publication of the novel himself. The novel takes place in the Bowery, a New York neighborhood in lower Manhattan.- Excerpted from Wikipedia, the free encyclopedia.

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The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides.

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Robert DARNTON

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A great book about an even greater book is a rare event in publishing. Robert Darnton’s history of the Encyclopédie is such an occasion. The author explores some fascinating territory in the French genre of histoire du livre, and at the same time he tracks the diffusion of Enlightenment ideas. He is concerned with the form of the thought of the great philosophes as it materialized into books and with the way books were made and distributed in the business of publishing. This is cultural history on a broad scale, a history of the process of civilization. In tracing the publishing story of Diderot’s Encyclopédie, Darnton uses new sources—the papers of eighteenth-century publishers—that allow him to respond firmly to a set of problems long vexing historians. He shows how the material basis of literature and the technology of its production affected the substance and diffusion of ideas. He fully explores the workings of the literary market place, including the roles of publishers, book dealers, traveling salesmen, and other intermediaries in cultural communication. How publishing functioned as a business, and how it fit into the political as well as the economic systems of prerevolutionary Europe are set forth. The making of books touched on this vast range of activities because books were products of artisanal labor, objects of economic exchange, vehicles of ideas, and elements in political and religious conflict. The ways ideas traveled in early modern Europe, the level of penetration of Enlightenment ideas in the society of the Old Regime, and the connections between the Enlightenment and the French Revolution are brilliantly treated by Darnton. In doing so he unearths a double paradox. It was the upper orders in society rather than the industrial bourgeoisie or the lower classes that first shook off archaic beliefs and took up Enlightenment ideas. And the state, which initially had suppressed those ideas, ultimately came to favor them. Yet at this high point in the diffusion and legitimation of the Enlightenment, the French Revolution erupted, destroying the social and political order in which the Enlightenment had flourished. Never again will the contours of the Enlightenment be drawn without reference to this work. Darnton has written an indispensable book for historians of modern Europe. Paperback available from Harvard University Press.

Franklin K Mathiews (editor)

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