Myeloprotective Strategies Remyelinating therapies and specifically targeted myeloprotection have been suggested as therapeutic options in things like MS and neuropsychiatric disorders including psychotic- spectrum disorders. There is no consensus across randomised control studies in order to support recommendation of a specific diet or dietary component for remyelination. "An ideal therapeutic strategy would be both anti-inflammatory and would enhance neural repair with minimal side effects" Repair usually occurs by promoting the secretion of neurotrophins (NGF, BDNF) which can promote oligodendrocyte precursor cell proliferation and repair of the nervous system. Natural products have the potential to increase the survival rate of neural stem cells and promote the differentiation of neural stem cells into oligodendrocytes, which promotes the formation of myelin sheath, then contributing to remyelination. Remyelination could potentially be facilitated by the modulation of the inflammatory environment and glutathione/redox regulation have a critical role in myelination processes and white matter maturation. Voluntary exercise can promote both neuroprotection and neuroregeneration Fasting/calorie restriction resulted in more complete remyelination Omega-3 PUFAs were demonstrated to promote, in vivo, the expression of myelin-related proteins Vitamin D3 supplementation decreases the magnitude of white matter demyelination Dietary polyphenols could mitigate demyelination by modulating the immune response, limiting demyelination, reducing neuroinflammation, and downregulating immune functions Ensuring diet contains plenty of B vitamins, Vitamin E and choline may help Spirulina promoted white matter regeneration, C-Phycocyanin and Phycocyanobilin having a potent remyelinating action 1 Some natural products with proposed myelo-restorative actions include: - H. erinaceus had a regulatory effect on the process of myelin genesis - Baicalin had a remyelinating effect - Hesperidin - Diosgenin - 18β - Glycyrrhetinic acid and glycyrrhizic acid directly enhanced remyelination rather than via immunomodulation. It is proposed to be an anti-inflammatory and neural repair agent, especially at later stages when when axonal damage and neuron loss have already occurred - Scutellarin - Cannabidiol - Matrine - Icariin - Resveratrol - Oligomeric proanthocyanidin reduced demyelination and increased expression of myelin basic protein whilst inhibiting inflammatory factors 2