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Das Vertrauen von Patienten und Probanden ist eine unverzichtbare Voraussetzung für den Erfolg medizinischer Forschungsprojekte, die ohne die Erhebung, langfristige Speicherung und Analyse von klinischen Daten und Proben nicht durchgeführt werden können. Medizinische Forschung arbeitet heute überwiegend vernetzt in zunehmend größeren Forschungsverbünden. Entsprechend nimmt auch die Bedeutung von Datenschutz und Datensicherheit immer weiter zu. Die TMF hat bereits 2003 erstmals generische Datenschutzkonzepte für medizinische Forschungsverbünde veröffentlicht. Auf dieser Basis konnten zahlreiche Forschungsprojekte ihre Datenschutzkonzepte schneller erarbeiten und abstimmen. Die dabei gewonnenen Erfahrungen sind in die grundlegende Überarbeitung der generischen Konzepte eingeflossen. So trägt das neue Konzept der Vielschichtigkeit medizinischer Forschungsprozesse durch einen modularen Aufbau Rechnung und wurde zudem in einen umfassenden Leitfaden eingebettet.

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There is an assumption that environmental threats could cause important damages in central nervous system. As a consequence, several forms of brain structural plasticity could be affected. The environmentally mediated risks include generally physical (such as brain and spinal cord injury) and psychological / psychosocial influences (e.g. stress). In general, the response of the organism to these environmental challenges passes via adaptive responses to maintain homeostasis or functional recovery. These processes engage the immune system, the autonomic nervous system (ANS) besides the hypothalamo-hypophyseo-adrenal (HPA) axis via specific hormones, neurotransmitters, neuropeptides and other factors which participate, in several cases, in structural remodeling in particular brain areas. To what extent a brain and / or spinal cord recovery after structural and / or physiological / psychological damage could occur and by which mechanisms, this is the goal of this Research Topic. It concerns neurogenesis, growth factors and their receptors, and morphological plasticity. On the other hand, it is well known that stress experienced an obvious impact on many behavioral and physiological aspects. Thus, environmental stress affects neuroendocrine structure and function and hence such aspects may influence brain development. Knowing normal organization of neurotensin receptors’ system during postnatal development in human infant will help understanding the dysfunction of this neuropetidergic system in “sudden infant syndrome” victims. Stress could affect also other non-neuroendocrine regions and systems. GABA is one of the classical neurotransmitter sensitive to stress either when applied acutely or repetitively as well as its receptor GABAA. Furthermore, the modulation of this receptor complex notably by neurosteroids is also affected by acute stress. These steroids seem to play a role in the resilience retained by the stressed brain. Their modulatory role will be studied in the context of chronic stress in rats. Finally, one of the major impacts of stress besides changes in psychological behavior is the alteration of food intake control causing in final eating disorders. This alteration is the result of changes occurring in activity of brain regions involved in stress responses (principally HPA and ANS) and which are also involved in food intake control. The series of studies presented here, will try to explain how different stress paradigms affect this function and the eventual interactions of glucocorticoids with orexigenic (neuropetide Y: NPY/Agouti Related Peptide: AgRP) and anorexigenic peptides (Pre-opiomelanocortin peptide: POMC/Cocaine Amphetamine regulatory Transcript peptide: CART).

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Mary Macleod (editor)

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Tartarin of Tarascon (French: Tartarin de Tarascon) is an 1872 novel written by the French author Alphonse Daudet. From Wikipedia (CC BY-SA).

The Movers

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Vikas Irukula

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Vanshika Shamra

Fairfield Market Research

The demand within the global anti-rheumatics market is a function of advancements in orthopedics and general healthcare. Rheumatoid arthritis (RA) can majorly disrupt the quality of life in affected individuals, making it necessary for the healthcare industry to develop effective lines of treatment and management.

Louis Untermeyer (editor)

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Edna Ferber

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Edusum

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Moncure Daniel Conway

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CamScanner

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Demenko, Denys

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