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This Special Issue deals with the theory and applications of differential and difference equations, and includes papers for different branches of differential equations, such as - Boundary Value Problems for Fractional Differential Equations and Inclusions - Spectral Theory for Fractional Differential Equations - Generalized Abel's Integral Equations - Oscillation Results for Higher Order Differential Equations - Stability of Equilibria under Stochastic Perturbations - Harmonic Functions - Coincidence Continuation Theory for Multivalued Maps - Generalized Briot–Bouquet Differential Equation - Nonlocal Inverse Problem - Lyapunov Type Theorems for Exponential Stability - Fuzzy Functions on Time Scales - Modified Helmholtz Equation on a Regular Hexagon