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Antimicrobial resistance (AMR) is a global problem with extremely complex epidemiology involving the direct and indirect transmission of antibiotic resistant pathogens and mobile genetic elements between humans, animals, and the environment. AMR is, therefore, recognized as a ‘One Health’ issue. Data that describe AMR prevalence and trends are required to enable the judicious and prudent use of antimicrobials in animals, which has implications both from veterinary and animal welfare aspects as well as from a zoonotic and public health perspective. Horses are a potential reservoir of AMR for humans due to close human–animal contact, as was demonstrated with shared human and horse methicillin-resistant Staphylococcus aureus (MRSA) strains causing outbreaks in equine hospitals. Extended-spectrum beta-lactamase-producing Enterobacteriaceae, considered as clinically and economically important to the AMR burden in human and veterinary medicine, has been reported in both community and clinic equine populations. Strains of Enterobacteriaceae pose a major worldwide threat due to the geographical expansion of ESBL-producing clones as well as the horizontal interspecies dissemination of ESBL-encoding plasmids and genes. In human medicine, ESBL-E infection is associated with increased morbidity, mortality, length of hospital stay, delay of targeted appropriate treatment, and higher costs. These issues also need to be addressed in horses. This Special Issue on AMR in horses encompasses several papers that describe the prevalence, risk factors, and molecular data on MDR bacteria in healthy horses in Canada, Japan, Spain, and Israel, in addition to papers that describe the clinical impact of MDR bacteria in diseased horses in Austria, USA, France and Israel.
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The "Third Way" is said to be the guiding philosophy for New Labour and centre-left parties and governments across the globe. Moving beyond attempts to define and defend the "Third Way", this collection embarks upon a critical examination of this key concept. The editors draw on expert contributions from a range of disciplines and perspectives to dissect the "Third Way" in theory and practice, assess its legacy and suggest alternatives. The book begins by reviewing attempts to define the "Third Way". It then examines what the "Third Way" implies for our understanding of the economy and the state, before critically assessing the philosophical and practical implications of its attempts to use the term "community". The final section deconstructs "Third Way" rhetoric and discourse. The conclusion reviews how these critical insights might form a basis for alternative political projects. Written in a rigorous but accessible style, this interdisciplinary collection should be useful reading for anyone with an interest in understanding a key idea propounded by New Labour and the contemporary centre-left. It should appeal to anyone studying politics, sociology, contemporary history, social policy, social and political theory, and applied philosophy. It provides both an introduction to the topic and new and original insights for specialists in the area.
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The story of Biographia Literaria begins in a conversation between two friends, Wordsworth and Coleridge, both settled in the Lake District after their return from Germany in 1799. They were debating what form a second edition of the Lyrical Ballads should take to replace the exhausted edition of 1798. In the course of a walk the idea of replacing the brief Advertisement by a critical Preface was conceived. In the aged memory of Wordsworth many years after, the idea and indeed the very substance of the Preface as he came to write it were all Coleridge's. 'I have never cared a straw about the theory,' he wrote impatiently on the manuscript of Barron Fields biography of him, 'and the Preface was written at the request of Mr. Coleridge out of sheer good nature. I recollect the very spot, a deserted quarry in the Vale of Grasmere, where he pressed the thing upon me, and but for that it would never have been thought of.' By 1815, of course, when he came to write the Biographia, the Preface was 'Wordsworth' and the Biographia Coleridge's reply to Wordsworth but the simplification is much too crude. It poses and tries to answer two closely connected questions: first, what relation should the language of poetry bear to that of ordinary life? And secondly, what relation should the subject of poetry bear to itself? (The order in which the questions are put look irrational, but it is Wordsworth's own order and there are good reasons for it.) The answers of the Preface are 'the real language of men in a state of vivid sensation' and 'the incidents of common life.' These two questions, or rather Coleridge's attempt to modify and clarify the old answers to them, are together the central theme of the second half of the Biographia.
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