The collection covers the presentations held at the workshop on „Challenge: Securing Resources - Animal Diseases and Pest Control in the 18th and 19 Century“ held in Goettingen on 21 and 22 June 2006 by the graduate school „Interdisciplinary Environmental History, Natual Environment and Society in Central Europe“, which is funded by the German Research Foundation, and operative since July 1 2004 at the Georg-August University in Goettingen.Das von der Deutschen Forschungsgemeinschaft geförderte Graduiertenkolleg Interdisziplinäre Umweltgeschichte. Naturale Umwelt und gesellschaftliches Handeln in Mitteleuropa hat am 1. Juli 2004 an der Georg-August-Universität in Göttingen seine Arbeit aufgenommen. Im Interesse forschungsorientierter Interdisziplinarität gruppiert sich das Studienprogramm des Graduiertenkollegs um eine Reihe von Workshops mit deutschen und internationalen Vertretern umweltgeschichtlicher Disziplinen.Der vorliegende Band ist das Ergebnis eines Workshops, welchen die HerausgeberInnen am 21. und 22. Juni 2006 in Göttingen unter dem Titel: Herausforderung Ressourcensicherung Zur Viehseuchen und Schädlingsbekämpfung im 18. und 19. Jahrhundert veranstalteten.WissenschaftlerInnen aus Dänemark, Deutschland, Kanada, Österreich, der Schweiz und den Up. waren eingeladen worden, in diesem Kontext unterschiedliche Aspekte des Mensch-Natur-Verhältnisses zu erörtern. Der Workshop hatte das Ziel, durch die Verknüpfung verschiedener geschichtswissenschaftlicher Ansätze neue Perspektiven auf die Geschichte der Wahrnehmung und Bekämpfung von Schädlingen und Tierseuchen in der frühen Neuzeit zu eröffnen. Dieser Tagungsband enthält ausgewählte Beiträge des Workshops, welche besonders die Wechselwirkungen zwischen Ökonomie, Umwelt und Gesellschaft in Krisenzeiten analysieren.
Cover; The Mayor's Wife; Copyright; CONTENTS; CHAPTER I; A SPY'S DUTY; CHAPTER II; QUESTIONS; CHAPTER III; IN THE GABLE WINDOW; CHAPTER IV; LIGHTS -- SOUNDS; CHAPTER V; THE STRANGE NEIGHBORS NEXT DOOR; CHAPTER VI; AT THE STAIR-HEAD; CHAPTER VII; A MOVING SHADOW; CHAPTER VIII; THE PARAGRAPH; CHAPTER IX; SCRAPS; CHAPTER X; A GLIMMER OF THE TRUTH; CHAPTER XI; BESS; CHAPTER XII; SEARCHINGS; CHAPTER XIII; A DISCOVERY; CHAPTER XIV; I SEEK HELP; CHAPTER XV; HARDLY A COINCIDENCE; CHAPTER XVI; IN THE LIBRARY; CHAPTER XVIII; THE TWO WEIRD SISTERS; CHAPTER XVIII; THE MORNING NEWS; CHAPTER XIX.
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain. Correctly classifying the pathogenicity of genomic variants from amongst the large number of variants identified by next-generation sequencing is recognized as perhaps the major challenge facing the field. Deep phenotyping (e.g., imaging, movement analysis) techniques can aid variant interpretation by correctly classifying individuals as affected or unaffected for segregation studies. The lack of information on the clinical phenotype of novel genetic subtypes of neurological disease creates limitations for genetic counselling. Both deep phenotyping and qualitative studies can capture the clinical and patient’s perspective on a disease and provide valuable information. This Special Issue aims to highlight how next-generation sequencing techniques have revolutionised our understanding of the aetiology of brain disease and describe the contribution of deep phenotyping studies to a variant interpretation and understanding of natural history.
Translated into English rhyming verse with explanatory notes by Gilbert Murray.
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