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This book is a collection of Special Issue articles with a multidisciplinary character, linking biology, medicine, and synthetic organic chemistry. The synthesis and full characterization of about 180 novel organic species, both of natural and synthetic origin, often designed with the support of in-silico studies, are set out in the book. In several articles, molecular hybridization approaches have been used as a successful multi-target strategy for the design and development of novel antitumor agents. Rigorous and careful biochemical studies ranging from in-vitro experiments on a plethora of human-cancer derived cell lines to in-vivo and ex-vivo studies allowed the authors to identify the molecular targets and gain useful information on structure–activity relationships (SAR). For this reason, this collection should interest many readers from different scientific fields.

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This exciting book provides an illuminating account of contemporary globalization that is grounded in actual transformations in the areas of production and the workplace. It reveals the social and political contests that give 'global' its meaning, by examining the contested nature of globalization as it is expressed in the restructuring of work. Rejecting conventional explanations of globalization as a process that automatically leads to transformations in working lives, or as a project that is strategically designed to bring about lean and flexible forms of production, this book advances an understanding of the social practices that constitute global change. Through case studies that span from the labour flexibility debates in Britain and Germany, to the strategies and tactics of corporations and workers, the author examines how globalization is interpreted and experienced in everyday life. Contestation, she argues, is about more than just direct protests and resistances. It has become a central feature of the practices that enable or confound global restructuring. This book offers students and scholars of international political economy, sociology and industrial relations an innovative framework for the analysis of globalisation and the restructuring of work.

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Discrete optimization is an important area of Applied Mathematics with a broad spectrum of applications in many fields. This book results from a Special Issue in the journal Mathematics entitled ‘Advances and Novel Approaches in Discrete Optimization’. It contains 17 articles covering a broad spectrum of subjects which have been selected from 43 submitted papers after a thorough refereeing process. Among other topics, it includes seven articles dealing with scheduling problems, e.g., online scheduling, batching, dual and inverse scheduling problems, or uncertain scheduling problems. Other subjects are graphs and applications, evacuation planning, the max-cut problem, capacitated lot-sizing, and packing algorithms.

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