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Mathematical finance plays a vital role in many fields within finance and provides the theories and tools that have been widely used in all areas of finance. Knowledge of mathematics, probability, and statistics is essential to develop finance theories and test their validity through the analysis of empirical, real-world data. For example, mathematics, probability, and statistics could help to develop pricing models for financial assets such as equities, bonds, currencies, and derivative securities.

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The discovery of antibiotics represented a key milestone in the history of medicine. However, with the rise of these life-saving drugs came the awareness that bacteria deploy defence mechanisms to resist these antibiotics, and they are good at it. Today, we appear at a crossroads between discovery of new potent drugs and omni-resistant superbugs. Moreover, the misuse of antibiotics in different industries has increased the rate of resistance development by providing permanent selective pressure and, subsequently, enrichment of multidrug resistant pathogens. As a result, antimicrobial resistance has now become an urgent threat to public health worldwide (http://www.who.int/drugresistance/documents/surveillancereport/en/). The development of multidrug resistance (MDR) in an increasing number of pathogens, including Pseudomonas, Acinetobacter, Klebsiella, Salmonella, Burkholderia, and other Gram-negative bacteria is a most severe issue. Membrane efflux pump complexes of the Resistance-Nodulation-cell Division (RND) superfamily play a key role in the development of MDR in these bacteria. RND pumps, together with other transporters, contribute to intrinsic and acquired resistance to most, if not all, of the antimicrobial compounds available in our drug arsenal. Given the enormous drug polyspecificity of MDR efflux pumps, studies on their mechanism of action are extremely challenging, and this has negatively impacted both the development of new antibiotics that are able to evade these efflux pumps as well as the design of pump inhibitors. The collection of articles in this eBook, published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy, aims to update the reader about the latest advances on the structure and function of RND efflux transporters, their roles in the overall multidrug resistance phenotype of Gram-negative pathogens, and on strategies to inhibit their activities. A deeper understanding of the mechanisms by which RND efflux pumps, alone or synergistically with other efflux pumps, are able to limit the concentration of antimicrobial compounds inside the bacterial cell, may pave the way for new, more directed, inhibitor and antibiotic design to ultimately overcome antimicrobial resistance by Gram-negatives.

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Mirnah Technology Systems

Mirnah is known for its ability to offer cutting-edge software solutions for enterprises. With its personalized software packages like Android IOS native flutter and QlikPowerBI Business Intelligence.

Prepare with confidence using the Zscaler Digital Transformation Engineer (ZDTE) Practice Test PDF from Cert007. Featuring updated and real exam-style questions, this PDF helps you master key concepts, practice effectively, and boost your chances of passing the exam on the first try.

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Prepare with confidence using the Dell Midrange Storage Solutions Design D-MSS-DS-23 Practice Test PDF from Cert007. Featuring updated and real exam-style questions, this PDF helps you master key concepts, practice effectively, and boost your chances of passing the exam on the first try.

Xiwen Du

Data in Brief, 38 (2021) 107352. doi:10.1016/j.dib.2021.107352

Prepare with confidence using the Cohesity NetBackup Appliances COH-285 Practice Test PDF from Cert007. Featuring updated and real exam-style questions, this PDF helps you master key concepts, practice effectively, and boost your chances of passing the exam on the first try.

Prepare with confidence using the Citrix CCP-AppDS-NetScaler 1Y0-342 Practice Test PDF from Cert007. Featuring updated and real exam-style questions, this PDF helps you master key concepts, practice effectively, and boost your chances of passing the exam on the first try.

Prepare with confidence using the AWS Certified Security - Specialty SCS-C03 Practice Test PDF from Cert007. Featuring updated and real exam-style questions, this PDF helps you master key concepts, practice effectively, and boost your chances of passing the exam on the first try.

Prepare with confidence using the Adobe Experience Manager AD0-E125 Practice Test PDF from Cert007. Featuring updated and real exam-style questions, this PDF helps you master key concepts, practice effectively, and boost your chances of passing the exam on the first try.

Ardi Nurhidayanto

Flashstake Dapp UI Sugesstions

Melbourne Airport Taxi Provides Tips for a Safe Ride

Alternatively, you can arrange to have a friend take you. However, you should not accept a ride from a stranger unless you know him well. Read the post to know more about hiring Melbourne’s Airport Taxi services.

4BHK luxury flats in Mohali

Zirakpur has emerged as the primary choice for homeowners seeking to spend their hard-earned money on a secure and dependable property residential and commercial property in Zirakpur.

lenovo

Fourton Associates PLLC

Some people might not be aware that they need to bring anything at all to a business attorney nyc, let alone what they need to bring. You can at least give a general response here, even though the precise paperwork or documents you need may change depending on the particular claim or case they have. Tell them to bring any necessary documents, their ID, any current legal records (including police records), and so forth. They can be told here that you will be able to give them a precise list of what to bring once they call for a consultation. A lawyer from top law firms in nyc can even go the extra mile and offer you to fetch the documents if they have access to public records. For more details please visit https://www.fourtonassociates.com/best-law-firm-new-york

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G. A. (George Alfred) Henty

PD-US

PAP

La Gaset des Trois

CC BY-NC-ND

Although over eighty percent of the country is Muslim, Indonesia is marked by an extraordinary diversity in language, ancestry, culture, religion and ways of life. This book focuses on the Christian Dani of West Papua, providing a social and ethnographic history of the most important indigenous population in the troubled province. It presents a fascinating overview of the Dani’s conversion to Christianity, examining the social, religious and political uses to which they have put their new religion. Based on independent research carried out over many years among the Dani people, the book provides an abundance of new material on religious and political events in West Papua. Underlining the heart of Christian-Muslim rivalries, the book questions the fate of religion in late-modern times.

Richard Lukacs

Sherwood Anderson

CC BY-NC

In a deeply moving collection of interrelated stories, this 1919 American classic illuminates the loneliness and frustrations — spiritual, emotional and artistic — of life in a small town.

Dungeon Master