Helen H. (Helen Hamilton) Gardener

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John Stephen Farmer (editor)

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Variously attributed to Still, Bridges, or Stevenson.

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Anna Katharine Green

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Looking for a satisfying, meticulously plotted mystery with which to while away an afternoon? Look no further than "X Y Z," a short story from one of the most influential early writers in the genre, Anna Katherine Green. Her remarkable skill in leading readers to the unexpected but fascinating solution to this puzzle mystery makes this story an eminently worthwhile read.

Helen Hunt Jackson

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Owen Wister

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BarryI

Carl Von Clausewitz

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Cady Bag offers polypropylene packaging solutions such as Leno Mesh Packaging, Cotton Bale Packaging, Consumer Products, and Building Products/Industrial Coated Products.

George Mac Gregor

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Sanhita Sharma

Global Leaded Resistors Market Report 2022 Analysis by Manufacturers, Regions, Types, Applications, Size, Share, Growth, Trends and Forecast to 2028.

Mari Wolf

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CC BY

Recent biochemical studies indicate that calorie restriction (CR) is a widely accepted method for anti-aging intervention. CR and intermittent fasting (IF), which involves reduced calories but proper nutritional intake during specific periods, are interventions that can consistently promote health benefits, delay biological aging, and extend both average and maximal lifespan. Furthermore, CR can modulate age-related diseases such as Alzheimer’s disease, atherosclerosis, diabetes, obesity, cancer, and others. Advances in omics technologies have provided a technical breakthrough that enabled the investigation of DNA, RNA, proteins, and other cellular molecules and their comprehensive interactions in a biological context. Nowadays, it is possible to analyze and integrate biological processes that occur in aging systems at the molecular level using state-of-the-art techniques such as next-generation sequencing (NGS), proteomics, lipidomics, metabolomics, and epigenomics. Omics technology and systems gerontology provide predictive information on CR effects, molecular mechanisms, and pathways underlying the anti-aging actions of CR and IF. This Special Issue, “The effects of calorie restriction and intermittent fasting on health and disease”, focuses on the effects of calorie restriction and intermittent fasting on age-related inflammation, autophagy, metabolism, longevity, mitochondrial function, and age-related diseases.

IEEE Software;2021;38;6;10.1109/MS.2021.3102358

Anoopa Meena

Flocculation Instruments Market Report 2022 Analysis by Manufacturers, Regions, Types, Applications, Size, Share, Growth, Trends and Forecast to 2028.

Eric Goldstein

CC BY

Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Louis Couperus

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Jac Samson

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Thomas Wentworth Higginson

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Consists of the last five chapters of Higginson's "Travellers and Outlaws".

M Nieuwenhuis-von Üxküll-Güldenbandt (editor)

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FAMET - ANDALUCÍA

Autónomas en red

Harold Bell Wright

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Redemption of a bank robber.

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Philip José Farmer

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The Green Odyssey is an American science fiction novel written by Philip José Farmer. It was Farmer's first book-length publication, originally released by Ballantine in 1957. Unlike Farmer's most prolific earlier short story work, this book contains no sexual themes, though his next book Flesh returned to these motifs. The novel also appeared in the back ground of the first episode of The Twilight Zone. From Wikipedia (CC BY-SA).

Ricky Hidayat

CV updated