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This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results. Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward.

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Until now, research has given us only a limited understanding of how managers actually make sense of and apply management knowledge; how networks of interaction amongst managers help or hinder processes of knowledge diffusion and the sharing of best practice; and how these processes are all influenced both by the organisations in which managers act and by the professional communities of practice they belong to. Managing Modern Healthcare fills these important gaps in our understanding by drawing upon an in-depth study of management networks and practice in three healthcare organisations in the UK. It draws from the primary research a number of important and grounded lessons about how management networks develop and influence the spread of management knowledge and practice; how management training and development relates to the needs of managers facing challenging conditions; and how those conditions are themselves shaping the nature of management in healthcare. This book reveals how managers in practice are responding to the many contemporary challenges facing healthcare (and the NHS in particular) and how they are able or not to effectively exploit sources of knowledge, learning and best practice through the networks of practice they engage in to improve healthcare delivery and healthcare organisational performance. Managing Modern Healthcare makes a number of important theoretical contributions as well as practical recommendations. The theoretical and empirical contributions the book makes relate to wider work on networks and networking, management knowledge, situated learning/communities of practice, professionalization/professional identity and healthcare management more generally. The practical contribution comes in the form of recommendations for healthcare management practitioners and policy makers that are intended to impact upon and help enhance healthcare management delivery and performance.

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Antimicrobial resistance (AMR) is a global problem with extremely complex epidemiology involving the direct and indirect transmission of antibiotic resistant pathogens and mobile genetic elements between humans, animals, and the environment. AMR is, therefore, recognized as a ‘One Health’ issue. Data that describe AMR prevalence and trends are required to enable the judicious and prudent use of antimicrobials in animals, which has implications both from veterinary and animal welfare aspects as well as from a zoonotic and public health perspective. Horses are a potential reservoir of AMR for humans due to close human–animal contact, as was demonstrated with shared human and horse methicillin-resistant Staphylococcus aureus (MRSA) strains causing outbreaks in equine hospitals. Extended-spectrum beta-lactamase-producing Enterobacteriaceae, considered as clinically and economically important to the AMR burden in human and veterinary medicine, has been reported in both community and clinic equine populations. Strains of Enterobacteriaceae pose a major worldwide threat due to the geographical expansion of ESBL-producing clones as well as the horizontal interspecies dissemination of ESBL-encoding plasmids and genes. In human medicine, ESBL-E infection is associated with increased morbidity, mortality, length of hospital stay, delay of targeted appropriate treatment, and higher costs. These issues also need to be addressed in horses. This Special Issue on AMR in horses encompasses several papers that describe the prevalence, risk factors, and molecular data on MDR bacteria in healthy horses in Canada, Japan, Spain, and Israel, in addition to papers that describe the clinical impact of MDR bacteria in diseased horses in Austria, USA, France and Israel.

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The "Third Way" is said to be the guiding philosophy for New Labour and centre-left parties and governments across the globe. Moving beyond attempts to define and defend the "Third Way", this collection embarks upon a critical examination of this key concept. The editors draw on expert contributions from a range of disciplines and perspectives to dissect the "Third Way" in theory and practice, assess its legacy and suggest alternatives. The book begins by reviewing attempts to define the "Third Way". It then examines what the "Third Way" implies for our understanding of the economy and the state, before critically assessing the philosophical and practical implications of its attempts to use the term "community". The final section deconstructs "Third Way" rhetoric and discourse. The conclusion reviews how these critical insights might form a basis for alternative political projects. Written in a rigorous but accessible style, this interdisciplinary collection should be useful reading for anyone with an interest in understanding a key idea propounded by New Labour and the contemporary centre-left. It should appeal to anyone studying politics, sociology, contemporary history, social policy, social and political theory, and applied philosophy. It provides both an introduction to the topic and new and original insights for specialists in the area.

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