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Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IFN-I could serve as a double edge sword, either containing an infection or enhancing susceptibility. For example, IFN-I, which is essential for early containment of viral infections, has been shown to be detrimental to the host during bacterial infections. In fact, recent significant reports have shown that influenza virus induced IFN-I responses can enhance the host susceptibility to secondary bacterial infections. These recent reports highlight the expanding immunoregulatory role of IFN-I in the host immunity. With these recent findings in mind, the aim of this research topic is to welcome novel data, opinion and literature reviews on the newly identified dual functions of IFN-I. This research topic wills focus on the following areas of IFN-I: 1) a detrimental role of IFN-I during primary bacterial infection; 2) a detrimental role of viral infection induced IFN-I during secondary bacterial infections; 3) evolutionary pressure that drove detrimental IFN-I response during primary bacterial infection; and 4) does benefit of IFN-I responses during primary viral infections outweigh the adverse consequences of IFN-I mediated enhanced susceptibility to secondary bacterial infections.

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This modern treatise on compact models for circuit computer-aided design (CAD) presents industry standard models for bipolar-junction transistors (BJTs), metal-oxide-semiconductor (MOS) field-effect-transistors (FETs), FinFETs, and tunnel field-effect transistors (TFETs), along with statistical MOS models. Featuring exercise problems at the end of each chapter and extensive references at the end of the book, the text supplies fundamental and practical knowledge necessary for efficient integrated circuit (IC) design using nanoscale devices. It ensures even those unfamiliar with semiconductor physics gain a solid grasp of compact modeling concepts. This book is made open access as part of the Knowledge Unlatched KU Select 2018: STEM Backlist Books

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At a time when contemporary challenges seem to many to be insurmountable, this book offers an optimistic view of the future and provides a road map for societies to get there. Drawing upon extensive research and many years as a thought leader in environmental and sustainability issues in Japan and internationally, Hiroshi Komiyama analyzes the most pressing challenges to the attainment of sustainability of economically advanced nations and argues forcefully for Japan to lead them out of the present dilemma through active promotion of creative consumer and societal demand. He shows how an active industry–government–academic partnership can provide the environment needed to promote such new creative demand and illustrates its potential through presentation of a Platinum Society Network that was launched on a regional basis in Japan in 2010 to facilitate the solution of common issues through the exchange of information and ideas. What is perhaps most surprising about the text is its unwavering optimism supported by hard evidence, history, and insightful observation. Problems arising from new paradigms of the 21st century (what the author refers to as “exploding knowledge, limited Earth resources, and aging societies“) thwart sustainable development in advanced and developing countries alike. All countries will struggle with issues that evolve from these paradigms including diminishing resources, expanding budget deficits, and growing global environmental problems. This window on potential practical pathways and solutions should be of interest to all those engaged in seeking ways to meet these contemporary challenges.

Stella M Francis

PD-US

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