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Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.
Food safety is a major problem around the world, both with regard to human suffering and with respect to economic costs. Scientific advances have increased our knowledge surrounding the nutritional characteristics of foods and their effects on health. This means that a large proportion of consumers are much more conscious with respect to what they eat and their demands for quality food. Food quality is a complex term that includes, in addition to safety, other intrinsic characteristics, such as appearance, color, texture and flavor, and also extrinsic characteristics, such as perception or involvement.
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Cynthia Skenazi explores in this book a shift in attitudes towards aging and provides a historical perspective on a crucial problem of our time. In Aging Gracefully in the Renaissance: Stories of Later Life from Petrarch to Montaigne Cynthia Skenazi explores a shift in attitudes towards aging and provides a historical perspective on a crucial problem of our time. From the late fourteenth to the end of the sixteenth centuries, the elderly subject became a point of new social, medical, political, and literary attention on both sides of the Alps. A movement of secularization tended to dissociate old age from the Christian preparation for death, re-orienting the concept of aging around pragmatic matters such as health care, intergenerational relationships, and accrued insights one might wish to pass along. Such changes were accompanied by an increasing number of personal accounts of later life.
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📄 "Deconstructing Australian Genocide, Ecocide: the provenance and agency of Australia's dispossessory rule-based order" by ray gibbons
A PDF version of this book is available for free in open access via the OAPEN Library platform, www.oapen.org . Cyborgs in Latin America explores the ways cultural expression in Latin America has grappled with the changing relationships between technology and human identity.
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Since the late 1800s, the discovery of new viruses was a gradual process. Viruses were described one by one using a suite of techniques such as (electron) microscopy and viral culture. Investigators were usually interested in a disease state within an organism, and expeditions in viral ecology were rare. The advent of metagenomics using high-throughput sequencing has revolutionized not only the rate of virus discovery, but also the nature of the discoveries. For example, the viral ecology and etiology of many human diseases are being characterized, non-pathogenic viral commensals are ubiquitous, and the description of environmental viromes is making progress. This Frontiers in Virology Research Topic showcases how metagenomic and bioinformatic approaches have been combined to discover, classify and characterize novel viruses.
The members of the 19th century Basel Reading Society belonged to the socio-cultural bourgeoisie. This study is a biography of this group of members of civil society: its transformation is observed and interpreted against the backdrop of the club history of the Reading Society and within the local historical context. The collective body is analysed and portrayed with respect to both the imposed statutory framework, quantitative development, social, political and historical economic factors, and also to individual biographical data.Der Teilnehmerkreis der Basler Lesegesellschaft des langen 19. Jahrhunderts ist dem soziokulturellen Bürgertum zugeordnet.Die Studie biographiert diese bürgerliche Gruppe: Ihr Wandel wird beobachtet und vor dem Hintergrund der Vereinsgeschichte der Lesegesellschaft und des lokalen historischen Kontextes interpretiert. Das Kollektiv wird hinsichtlich selbst gesteckter Rahmenbedingungen, quantitativer Entwicklung, sozial-, politik- und wirtschaftsgeschichtlicher Faktoren, aber auch individuell-biographischer Daten analysiert und dargestellt.