2020 “Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures Through a PKC-Dependent Mechanism” https://pdfhost.io/v/VJbv.wzKL_101021acschemneuro0c00175.pdf 2019 “Unlocking the Drug Potential of the Bryostatin Family: Recent Advances in Product Synthesis and Biomedical Applications” https://pdfhost.io/v/BkncGb4U_wu2019pdf.pdf “Neuro-regeneration Therapeutic for Alzheimer’s Dementia: Perspectives on Neurotrophic Activity” https://pdfhost.io/v/xkXgoaXgm_sun2019pdf.pdf “Age-Dependent Levels of Protein Kinase Cs in Brain:Reduction of Endogenous Mechanisms of Neuroprotection” https://pdfhost.io/v/qeNstyaml_pastore2019pdf.pdf 2018 “A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer’s Disease” https://pdfhost.io/v/GEa58CPiF_farlow2018pdf.pdf “Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer’s Disease Hippocampus” https://pdfhost.io/v/9ZaifJXaW_sen2018pdf.pdf “Bryostatin-1 alleviates experimental multiple sclerosis” https://pdfhost.io/v/0Emeo4pmO_Bryostatin1_alleviates_experimental_multiple_sclerosis.pdf 2017 “ApoE isoforms differentially regulates cleavage and secretion of BDNF” https://pdfhost.io/v/zNE05OQtq_ApoE_isoforms_differentially_regulates_cleavage_and_secretion_of_BDNF.pdf “Bryostatin Effects on Cognitive Function and PKC epsilon in Alzheimer’s Disease Phase IIa and Expanded Access Trials” https://pdfhost.io/v/XAcILs@Hc_jad2F20172F5822Fjad582jad1701612Fjad58jad170161pdf.pdf “Effects of chronic bryostatin-1 on treatment-resistant depression in rats” https://pdfhost.io/v/aGZLtHTkT_Effects_of_chronic_bryostatin1_on_treatmentresistant_depression_in_rats.pdf 2016 “PKC epsilon Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95” https://pdfhost.io/v/4gpXjOeEx_Protein_Kinase_C_PKC_Promotes_Synaptogenesis_through_Membrane_Accumulation_of_the_Postsynaptic_Density_Protein_PSD95.pdf “Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice” https://pdfhost.io/v/oLXS8ixjY_61232238.pdf 2015 “ApoE4 and Ab Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation” https://pdfhost.io/v/0czXfehBi_sen2015pdf.pdf “Towards universal therapeutics for memory disorders” https://pdfhost.io/v/hyxb3ndO7_Towards_universal_therapeutics_for_memory_disorders.pdf “Identification of the PS1 Thr147Ile Variant in a Family with Very Early Onset Dementia and Expressive Aphasia” https://pdfhost.io/v/YHYIqAXsd_denvir2015pdf.pdf 2014 “The “Memory Kinases”: Roles of PKC Isoforms in Signal Processing and Memory Formation” https://pdfhost.io/v/16T7bA+2y_The_Memory_Kinases.pdf “Molecular Regulation of Synaptogenesis during Associative Learning and Memory” https://pdfhost.io/v/pzzkQ4cLC_Molecular_Regulation_of_Synaptogenesis_during_Associative_Learning_and_Memory.pdf “Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury” https://pdfhost.io/v/SnOjq23l+_luckewold2014pdf.pdf “PKC epsilon Deficits in Alzheimer’s Disease Brains and Skin Fibroblasts” https://pdfhost.io/v/obd6uLym1_khan2014pdf.pdf “Common Mechanisms of Alzheimer’s Disease and Ischemic Stroke: The Role of Protein Kinase C in the Progression of Age-Related Neurodegeneration” https://pdfhost.io/v/2zdkj7kQq_nihms659711pdf.pdf “Fibroblast Aggregation Rate Converges with Validated Peripheral Biomarkers for Alzheimer’s Disease” https://pdfhost.io/v/cMSYtUDi7_chirila2014pdf.pdf “PKC epsilon Promotes HuD-Mediated Neprilysin mRNA Stability and Enhances Neprilysin-Induced Abeta Degradation in Brain Neurons” https://pdfhost.io/v/O8YZhYdRr_deb_pone0097756_112.pdf “Bryostatin-1 Restores Hippocampal Synapses and Spatial Learning and Memory in Adult Fragile X Mice” https://pdfhost.io/v/wCFK6oQHk_JPET214098_393401.pdf “PKC activators enhance GABAergic neurotransmission and paired-pulse facilitation in hippocampal CA1 pyramidal neurons” https://pdfhost.io/v/KAOjfkY7t_PKC_activators_enhance_GABAergic_neurotransmission_and_pairedpulse_facilitation_in_hippocampal_CA1_pyramidal_neurons.pdf 2013 “Bryostatin Improves Survival and Reduces Ischemic Brain Injury in Aged Rats After Acute Ischemic Stroke” https://pdfhost.io/v/D4JhQkDvZ_tan2013pdf.pdf “Cerebral ischemia-induced difference in sensitivity to depression and potential therapeutics in rats” https://pdfhost.io/v/kbPwhxfwn_untitled.pdf “PKC activation during training restores mushroom spine synapses and memory in the aged rat” https://pdfhost.io/v/XaOz9ebyN_PKC_activation_during_training_restores_mushroom_spine_synapses_and_memory_in_the_aged_rat.pdf 2012 “Spatiotemporal Complexity of Fibroblast Networks Screens for Alzheimer’s Disease” https://pdfhost.io/v/mNj25xqyL_chirila2012pdf.pdf “Activation of Protein Kinase C Isozymes for the Treatment of Dementias” https://pdfhost.io/v/O+R2UfbUh_Activation_of_Protein_Kinase_C_Isozymes_for_the_Treatment_of_Dementias.pdf “Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase C epsilon” https://pdfhost.io/v/ER5g8o1sK_zbc15947pdf.pdf 2011 “PKC epsilon Activation Prevents Synaptic Loss, Ab Elevation, and Cognitive Deficits in Alzheimer’s Disease Transgenic Mice” https://pdfhost.io/v/LHJexkqPS_630fullpdf.pdf 2010 “PKC activator therapeutic for mild traumatic brain injury in mice” https://pdfhost.io/v/lX3Hy@kTb_PKC_activator_therapeutic_for_mild_traumatic_brain_injury_in_mice.pdf “Pharmacology of protein kinase C activators: Cognition-enhancing and antidementic therapeutics” https://pdfhost.io/v/oFTh@5Olu_sun2010pdf.pdf “PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD” https://pdfhost.io/v/nibBNBzUp_sun20101pdf.pdf 2009 “Protein Kinase C Activators as Synaptogenic and Memory Therapeutics” https://pdfhost.io/v/CgxNwiswm_Protein_Kinase_C_Activators_as_Synaptogenic_and_Memory_Therapeutics.pdf “Postischemic PKC activation rescues retrograde and anterograde long-term memory” https://pdfhost.io/v/813o@Axpj_14676fullpdf.pdf “A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Aβ-induced biomarker abnormality on cultured fibroblasts” https://pdfhost.io/v/q+qJLdW7M_khan2009pdf.pdf “Neuroprotective versus tumorigenic protein kinase C activators” https://pdfhost.io/v/URcMNc5Rp_doi101016jtibs200811006.pdf 2008 “Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains” https://pdfhost.io/v/7OnJfYmkZ_13620fullpdf.pdf “Analysis of long-term cognitive-enhancing effects of bryostatin-1 on the rabbit (Oryctolagus cuniculus) nictitating membrane response” https://pdfhost.io/v/MqcFy9uEW_untitled.pdf “Synergistic effects of chronic bryostatin-1 and α-tocopherol on spatial learning and memory in rats” https://pdfhost.io/v/n4Q1bUIJg_doi101016jejphar200802014.pdf 2007 “A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC” https://pdfhost.io/v/teMw7NdXe_19571fullpdf.pdf “PKC signaling deficits: a mechanistic hypothesis for the origins of Alzheimer's disease” https://pdfhost.io/v/v0ARwmN0V_doi101016jtips200612002.pdf 2006 “Protein Kinase C Pharmacology: Perspectives on Therapeutic Potentials as Antidementic and Cognitive Agents” https://pdfhost.io/v/0K4PAdy5l_sun2006pdf.pdf “Bryostatin Enhancement of Memory in Hermissenda” https://pdfhost.io/v/yi53e9CWd_Bryostatin_Enhancement_of_Memory_in_Hermissenda.pdf “Bryostatin-1: Pharmacology and Therapeutic Potential as a CNS Drug” https://pdfhost.io/v/OChrmI2CG_sun2006pdf.pdf 2005 “Protein synthesis required for long-term memory is induced by PKC activation on days before associative learning” https://pdfhost.io/v/LI2C0fdYK_16432fullpdf.pdf “Protein Kinase C Isozymes: Memory Therapeutic Potential” https://pdfhost.io/v/ZM3bAPo8g_untitled.pdf “Protein kinase C substrate activators: Potential as novel antidepressants” https://pdfhost.io/v/zETritLcN_sun20051pdf.pdf “Dual effects of bryostatin-1 on spatial memory and depression” https://pdfhost.io/v/e@hkDAO0O_doi101016jejphar200502028.pdf 2004 “Therapeutic effects of PKC activators in Alzheimer’s disease transgenic mice” https://pdfhost.io/v/9t+J32cfH_11141fullpdf.pdf
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-