Albizia julibrissin - “Collective Happiness Bark” “[Mimosa] was traditionally used to ‘calm the spirit’ and relieve emotional constraint when associated with bad temper, bad mood, sadness, occasional sleeplessness, irritability and poor memory. It was believed to be especially useful for anyone experiencing profound heart-breaking loss.” Albizia julibrissin is in the Fabaceae in the mimosoid clade of the subfamily Caesalpinioideae. One herbalist notes "Albizia offers a more profound effect in treating depression and anxiety than the two most commonly promoted herbs" [1] and interactions with pharmaceutical antidepressants have not been noted. 1 Antidepressant effects and constituents as detailed by Huang, Wu et al (2023) [2] (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1 → 2)-β-D-glucopyranoside (SAG) binds to an allosteric site on 5-HT, NE and DA transporters [3, 4] increasing the levels of neurotransmitters (NE, 5-HT, DA) in a stress-induced model of depression [5] ⦁ 5-HT1A mediated effects [6, 7, 8] and dual GABAA/5-HT1A mediated effects by Julibroside C1 [9] References [1]Michael Tierra "FOR MANY, AN EFFECTIVE NATURAL APPROACH FOR THE TREATMENT OF MILD STATES OF DEPRESSION AND ANXIETY" https://planetherbs.com/research- center/specific-herbs-articles/albizia-the-tree-of-happiness/ [2] Huang B, Wu Y, Li C, Tang Q, Zhang Y. Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae. Chin Herb Med. 2023 Mar 15;15(2):201-213. https://doi.org/10.1016/j.chmed.2022.10.004 [3] Huang, Bishan, Hanhe Liu, Yingyao Wu, Chan Li, Qingfa Tang, and Yuan-Wei Zhang. (2022) Two Lignan Glycosides from Albizia julibrissin Durazz. Noncompetitively Inhibit Serotonin Transporter Pharmaceuticals 15, 3: 344. https://doi.org/10.3390/ph15030344 [4] Liu Hanhe, Wu Yingyao, Li Chan, Tang Qingfa, Zhang Yuan-Wei (2022) Molecular docking and biochemical validation of (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1 → 2)-β-D- glucopyranoside binding to an allosteric site in monoamine transporters Frontiers in Pharmacology 13 https://doi.org/10.3389/fphar.2022.1018473 [5] Liu, Jie, Yue-Wei Lv, Jin-Li Shi, Xiao-Jie Ma, Yi Chen, Zhi-Quan Zheng, Sheng-Nan Wang, and Jian-You Guo. 2017. "Anti-Anxiety Effect of ( − )-Syringaresnol-4-O-β-d-apiofuranosyl-(1 → 2)-β-d-glucopyranoside from Albizzia julibrissin Durazz (Leguminosae)" Molecules 22, no. 8: 1331. https://doi.org/10.3390/molecules22081331 [6] Won-Ki Kim, Ji Wook Jung, Nam Yoon Ahn, Hye Rim Oh, Bo Kyung Lee, Jin Kyung Oh, Jae 2 Hoon Cheong, Hyang Sook Chun, Jong Hoon Ryu (2004) Anxiolytic-like effects of extracts from Albizzia julibrissin bark in the elevated plus-maze in rats, Life Sciences,Volume 75, Issue 23,Pages 2787-2795, https://doi.org/10.1016/j.lfs.2004.05.024 [7] Ji-Hyun Kim, Sun Yeou Kim, Seok-Yong Lee, Choon-Gon Jang (2007) Antidepressant-like effects of Albizzia julibrissin in mice: Involvement of the 5-HT1A receptor system, Pharmacology Biochemistry and Behavior, Volume 87, Issue 1, Pages 41-47 https://doi.org/10.1016/j.pbb.2007.03.018 [8] Ji Wook Jung, Jae-Han Cho, Nam Yoon Ahn, Hye Rim Oh, Sun Yeou Kim, Choon-Gon Jang, Jong Hoon Ryu (2005) Effect of chronic Albizzia julibrissin treatment on 5- hydroxytryptamine1A receptors in rat brain, Pharmacology Biochemistry and Behavior, Volume 81, Issue 1, Pages 205-210, https://doi.org/10.1016/j.pbb.2005.03.014 [9] Yang-Hee Jung, Ri-Ra Ha, Seung-Hwan Kwon, Sa-Ik Hong, Kun-Ho Lee, Sun-Yeou Kim, Seok-Yong Lee, Choon-Gon Jang (2013) Anxiolytic effects of Julibroside C1 isolated from Albizzia julibrissin in mice, Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 44, Pages 184-192, https://doi.org/10.1016/j.pnpbp.2013.02.012 3