PROSPERO EXPLAINED: WHY PROTOCOL REGISTRATION MATTERS Group: pubrica.com Email : sales@pubrica.com PROSPERO is an international, free database for prospective registration of systematic reviews, primarily in health and social care, designed to reduce research duplication, minimize reporting bias, and increase transparency. It allows researchers to post their planned methods before starting, ensuring that final findings are not selectively reported to fit desired outcomes. INTRODUCTION IMPORTANCE IN EVIDENCE-BASED HEALTHCARE Evidence-based healthcare relies heavily on systematic reviews and meta-analyses to guide further research, influence clinical practice and contribute to the development of health policy. The value of systematic reviews and meta- analyses is only possible through methodological transparency and the mitigation of bias throughout the process. PROSPERO REGISTRY The PROSPERO registry for systematic reviews provides a publicly accessible platform that supports research protocol registration importance across health and social care disciplines. The use of PROSPERO to document the methods that will be used in a systematic review prior to data extraction will help guard against research misconduct, minimize the risk of selective reporting and enhance the confidence that clinicians and researchers have in published evidence. WHAT IS PROSPERO? PROSPERO is a free and open-access, global database of registered protocols for systematic reviews making use of health- related outcomes in humans. Researchers can register systematic review protocol PROSPERO to ensure transparency before initiating study selection or data extraction. WHY PROTOCOL REGISTRATION MATTERS Reduces the risk of selective outcome reporting Prevents post hoc methodological changes to systematic reviews Increases accountability to readers or reviewers Increases reproducibility of systematic reviews The earlier you register, the more likely you are to make analytical decisions based on scientific reasons rather than evolving results. EMAIL sales@pubrica.com WEBSITE pubrica.com +44 161 394 0786 (UK) +91-9884350006 (IN) +1 972 502 9262 (USA) CONTACT US