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Dual Specificity Phosphatases
CC BY-NC-ND
Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
The Pig Brother, and Other Fables and Stories A Supplementary Reader for the Fourth School Year
Laura Elizabeth Howe Richards
PD-US
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Communities and knowledge production in archaeology
CC BY-NC-ND
The dynamic processes of knowledge production in archaeology and elsewhere in the humanities and social sciences are increasingly viewed as the collaborative effort of groups, clusters and communities of researchers rather than the isolated work of so-called ‘instrumental’ actors. Shifting focus from the individual scholar to the wider social contexts of her work and the dynamic creative processes she participates in, this volume critically examines the importance of informal networks and conversation in the creation of knowledge about the past. Engaging with theoretical approaches such as the sociology and geographies of knowledge and Actor-Network Theory (ANT), and using examples taken from different archaeologies in Europe and North America from the seventeenth to the mid-twentieth century, the book caters to a wide readership, ranging from students of archaeology, anthropology, classics and science studies to the general reader.This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Frontlist Books
Adventure
Jack London
PD-US
Though novelist Jack London is best known for the paean to natural wonder that is The Call of the Wild, he had an activist side, as well. In Adventure, London describes and skewers the plantation system of The Solomon Islands in a devastating take-down that is equal parts adventure tale and social justice tract.
Thermo Elite - Expert Home Inspections in Kirkland
Thermo Elite
Purchasing or selling a home is one of the biggest financial decisions you’ll ever make. Thermo Elite provides reliable home inspection services in Kirkland to give both buyers and sellers the confidence and peace of mind needed to make such an important financial investment. Our inspectors are certified professionals, provide premier inspection services and use cutting-edge technology including thermal imaging inspections that detect hidden problems that are not seen in a typical home inspectio
Peak Construction & Dry Rot Repair Sacramento
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iPad Screen Repair NJ â Affordable Cracked Screen Fixes
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No Name
Wilkie Collins
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Condemned by Victorian critics as immoral, but regarded today as a novel of outstanding social insight,No Nameshows William Wilkie Collins at the height of his literary powers. It is the story of two sisters, Magdalen and Norah, who discover after the deaths of their dearly beloved parents that their parents were not married at the time of their births. Disinherited and ousted from their estate, they must fend for themselves and either resign themselves to their fate or determine to recover their wealth by whatever means. About the Series:For over 100 yearsOxford World's Classicshas made available the broadest spectrum of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, voluminous notes to clarify the text, up-to-date bibliographies for further study, and much more.
Droll Stories — Volume 3
Honoré de Balzac
PD-US
Translation of: Les contes drôlatiques See also: Vol 1: #1925, Vol 2: #2318, and the complete work #13260
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Pet-Friendly Home Interior Design Ideas.pdf
Yuvraj Singh
Explore pet-friendly home interior design ideas by KreativEdge Interiors, blending style and functionality to create spaces that are both beautiful and safe for your pets.
The Pupil
Henry James
PD-US
- The poor young man hesitated and procrastinated: it cost him such an effort to broach the subject of terms, to speak of money to a person who spoke only of feelings and, as it were, of the aristocracy. Yet he was unwilling to take leave, treating his engagement as settled, without some more conventional glance in that direction than he could find an opening for in the manner of the large affable lady who sat there drawing a pair of soiled gants de Suede through a fat jewelled hand and, at once pressing and gliding, repeated over and over everything but the thing he would have liked to hear. He would have liked to hear the figure of his salary; but just as he was nervously about to sound that note the little boy came back - the little boy Mrs. Moreen had sent out of the room to fetch her fan. He came back without the fan, only with the casual observation that he couldn't find it. As he dropped this cynical confession he looked straight and hard at the candidate for the honour of taking his education in hand. This personage reflected somewhat grimly that the thing he should have to teach his little charge would be to appear to address himself to his mother when he spoke to her - especially not to make her such an improper answer as that.
The Top Benefits of Choosing Online Therapy in Westbrook, CT for Anxiety and Depression
The Power To Heal LLC
Online Therapy in Westbrook, CT
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