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Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options.Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.
This book shows that William Shakespeare was a more personal writer than any of his innumerable commentators have realised. It asserts that numerous characters and events were drawn from the author's life, and puts faces to the names of Jaques, Touchstone, Feste, Jessica, the 'Dark Lady' and others. Steven Sohmer explores aspects of Shakespeare's plays and sonnets that have been hitherto overlooked or misinterpreted in an effort to better understand the man and his work. If you've ever wondered who Pigrogromitus was, or why Jaques spies on Touchstone and Audrey - or what the famous riddle M.O.A.I. stands for - this is the book for you.This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Backlist Books
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Die Arbeit ist in drei Teile gegliedert: in den theoretischen Teil, den Untersuchungsteil und den Interpretationsteil. Der theoretische Teil weist vier Kapitel auf: in den ersten drei werden die Untersuchungstexte unter verschiedenen Gesichtspunkten eingeordnet; im letzten Kapitel des theoretischen Teils wird versucht, die Methodik der Untersuchung vorzustellen und zu begründen.
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Universal Health Coverage as defined by the World Health Organization encompasses equal access for all to good quality health services and with no financial risk for those in need of them. As such it is a modern term formulated on western ideas of health, however the philosophy it conveys has existed for many centuries across different regions and cultures of the world.'Health For All' is based on series of seminars which formed part of the World Health Organization's Global Health Histories project. It explores the development of universal health coverage in diverse contexts, the political and economic trends that effected the running of these schemes, and, not least, critical perspectives into the variety of links between structures of national universal healthcare systems.
This open access book promotes the idea that all media types are multimodal and that comparing media types, through an intermedial lens, necessarily involves analysing these multimodal traits. The collection includes a series of interconnected articles that illustrate and clarify how the concepts developed in Elleström’s influential article The Modalities of Media: A Model for Understanding Intermedial Relations (Palgrave Macmillan, 2010) can be used for methodical investigation and interpretation of media traits and media interrelations. The authors work with a wide range of old and new media types that are traditionally investigated through limited, media-specific concepts. The publication is a significant contribution to interdisciplinary research, advancing the frontiers of conceptual as well as practical understanding of media interrelations. This is the first of two volumes. It contains Elleström’s revised article and six other contributions focusing especially on media integration: how media products and media types are combined and merged in various ways.
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